Q20082 · ZNF2_CAEEL

  • Protein
    Zinc finger protein zfp-2
  • Gene
    zfp-2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Probable zinc finger transcription factor that acts as a transcriptional repressor. Acts redundantly with the transcriptional repressor lin-35 to control the development of somatic gonad lineages. May, in addition, suppress sensitivity to RNAi.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Zinc finger protein zfp-2

Gene names

    • Name
      zfp-2
    • ORF names
      F35H8.3

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q20082

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

No visible phenotype. Double knockout with lin-35 results in sterility, defects in gonad migration and vulval morphology.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004410151-422Zinc finger protein zfp-2

Proteomic databases

Expression

Tissue specificity

Expressed in vulval cells and all somatic gonad structures such as spermatheca, sheath cells, uterine cells and distal tip cells.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, zinc finger.

TypeIDPosition(s)Description
Compositional bias95-116Polar residues
Region95-119Disordered
Zinc finger171-194C2H2-type 1
Zinc finger200-222C2H2-type 2
Zinc finger229-251C2H2-type 3
Zinc finger255-278C2H2-type 4
Zinc finger300-322C2H2-type 5
Zinc finger328-350C2H2-type 6
Zinc finger356-379C2H2-type 7

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    422
  • Mass (Da)
    48,607
  • Last updated
    1996-11-01 v1
  • Checksum
    CB3BF05E74B00E56
MEEMMMNDPSAMVIYEEEVTTAPNLPCSLIQQRSWDEEKPIGYELTNTKCYKTPNGVQKTATIQREQLSTSKDFGEQQIVEMDGEFSIEGTDMHAIPCTSSSMQPSTSSNPSSGEHQPVPLRRMAIKIGQRVLRFKVISAEEAPEAPLDTQDSWINDPKPVTTPKALAGLYRCTNCKTYFGNKEVYQRHIQEVHGDARPFRCFNCGMRFANKTSMTHHLKDHSLLKPMFSCDYCPRIFSKLESKTRHHKMHFTRSTCQTCMRFFTTEDALRHHQSTAHPATFDSGPPPEDLLPNGKSARYSCSYCNLRFHFKKDMLVHERIHTGEKPYSCGYCMKSFAQSQALTAHIRTHTKELPYGCGKCDKRFRDNSCLRKHELAAHTDEPIVRPISVAYSNQVQKQMQRQRENRRKQELLIAERHPYRI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias95-116Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX284602
EMBL· GenBank· DDBJ
CAA85325.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp