Q20082 · ZNF2_CAEEL
- ProteinZinc finger protein zfp-2
- Genezfp-2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids422 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Probable zinc finger transcription factor that acts as a transcriptional repressor. Acts redundantly with the transcriptional repressor lin-35 to control the development of somatic gonad lineages. May, in addition, suppress sensitivity to RNAi.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameZinc finger protein zfp-2
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ20082
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
No visible phenotype. Double knockout with lin-35 results in sterility, defects in gonad migration and vulval morphology.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000441015 | 1-422 | Zinc finger protein zfp-2 | |||
Sequence: MEEMMMNDPSAMVIYEEEVTTAPNLPCSLIQQRSWDEEKPIGYELTNTKCYKTPNGVQKTATIQREQLSTSKDFGEQQIVEMDGEFSIEGTDMHAIPCTSSSMQPSTSSNPSSGEHQPVPLRRMAIKIGQRVLRFKVISAEEAPEAPLDTQDSWINDPKPVTTPKALAGLYRCTNCKTYFGNKEVYQRHIQEVHGDARPFRCFNCGMRFANKTSMTHHLKDHSLLKPMFSCDYCPRIFSKLESKTRHHKMHFTRSTCQTCMRFFTTEDALRHHQSTAHPATFDSGPPPEDLLPNGKSARYSCSYCNLRFHFKKDMLVHERIHTGEKPYSCGYCMKSFAQSQALTAHIRTHTKELPYGCGKCDKRFRDNSCLRKHELAAHTDEPIVRPISVAYSNQVQKQMQRQRENRRKQELLIAERHPYRI |
Proteomic databases
Expression
Tissue specificity
Expressed in vulval cells and all somatic gonad structures such as spermatheca, sheath cells, uterine cells and distal tip cells.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 95-116 | Polar residues | ||||
Sequence: AIPCTSSSMQPSTSSNPSSGEH | ||||||
Region | 95-119 | Disordered | ||||
Sequence: AIPCTSSSMQPSTSSNPSSGEHQPV | ||||||
Zinc finger | 171-194 | C2H2-type 1 | ||||
Sequence: YRCTNCKTYFGNKEVYQRHIQEVH | ||||||
Zinc finger | 200-222 | C2H2-type 2 | ||||
Sequence: FRCFNCGMRFANKTSMTHHLKDH | ||||||
Zinc finger | 229-251 | C2H2-type 3 | ||||
Sequence: FSCDYCPRIFSKLESKTRHHKMH | ||||||
Zinc finger | 255-278 | C2H2-type 4 | ||||
Sequence: STCQTCMRFFTTEDALRHHQSTAH | ||||||
Zinc finger | 300-322 | C2H2-type 5 | ||||
Sequence: YSCSYCNLRFHFKKDMLVHERIH | ||||||
Zinc finger | 328-350 | C2H2-type 6 | ||||
Sequence: YSCGYCMKSFAQSQALTAHIRTH | ||||||
Zinc finger | 356-379 | C2H2-type 7 | ||||
Sequence: YGCGKCDKRFRDNSCLRKHELAAH |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length422
- Mass (Da)48,607
- Last updated1996-11-01 v1
- ChecksumCB3BF05E74B00E56
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 95-116 | Polar residues | ||||
Sequence: AIPCTSSSMQPSTSSNPSSGEH |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX284602 EMBL· GenBank· DDBJ | CAA85325.1 EMBL· GenBank· DDBJ | Genomic DNA |