Q1YMX0 · Q1YMX0_AURMS
- ProteinCytochrome c oxidase subunit 1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids647 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2O
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | respirasome | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | oxidative phosphorylation | |
Biological Process | respiratory electron transport chain |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Aurantimonadaceae > Aurantimonas
Accessions
- Primary accessionQ1YMX0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 48-70 | Helical | ||||
Sequence: YIVTAFAFLIAGGIEALIMRIQL | ||||||
Transmembrane | 90-115 | Helical | ||||
Sequence: HGITMIFLYALPILSGFSNYLFPLLF | ||||||
Transmembrane | 127-149 | Helical | ||||
Sequence: AFSYWVYLASGLFMYSSFLIGAA | ||||||
Transmembrane | 173-197 | Helical | ||||
Sequence: FYALGMIFLGISTTVGAANFVVTFL | ||||||
Transmembrane | 209-238 | Helical | ||||
Sequence: IPIMVWGTTTISMGILLSVPAVSLAFFLLW | ||||||
Transmembrane | 258-282 | Helical | ||||
Sequence: LWQHLFWIFAHPWVYIIVLPAMGMA | ||||||
Transmembrane | 294-317 | Helical | ||||
Sequence: LVAYTLVVLGTISTMALGFGVWVH | ||||||
Transmembrane | 329-352 | Helical | ||||
Sequence: MSFFSGASFIITIPSAIAVFAWIA | ||||||
Transmembrane | 364-384 | Helical | ||||
Sequence: AFLYFAAFIAMFVIGGVSGVM | ||||||
Transmembrane | 404-424 | Helical | ||||
Sequence: IHYVLIGINLFGVLGGLHFWF | ||||||
Transmembrane | 436-457 | Helical | ||||
Sequence: LGRWTFWTIFAGFNLGFLPMHW | ||||||
Transmembrane | 477-503 | Helical | ||||
Sequence: SAMNMLTTVGSFIFAVGFAMLLVNVLV | ||||||
Transmembrane | 617-633 | Helical | ||||
Sequence: AAGAGLAILVGLLAWLW |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 20-541 | Cytochrome oxidase subunit I profile | ||||
Sequence: ARLRAIWETESGLMGWIGTVDHKEIGIRYIVTAFAFLIAGGIEALIMRIQLAGPEQSVVTPEQYDQLFSMHGITMIFLYALPILSGFSNYLFPLLFGSRDMAFPRLNAFSYWVYLASGLFMYSSFLIGAAPNDGWFNYAPYSLKDFNPGPNMDFYALGMIFLGISTTVGAANFVVTFLRCRAPGMSINRIPIMVWGTTTISMGILLSVPAVSLAFFLLWMDRQFGTHFYETGGGGEPLLWQHLFWIFAHPWVYIIVLPAMGMASDVLPVFCRRPLVAYTLVVLGTISTMALGFGVWVHHMFTTGIPYLSMSFFSGASFIITIPSAIAVFAWIATIWTGRIVVSAAFLYFAAFIAMFVIGGVSGVMTASVPADLQLHDTYFVVAHIHYVLIGINLFGVLGGLHFWFPKMSGRMLGERLGRWTFWTIFAGFNLGFLPMHWTGLLGMPRRIYTYPQDIGWSAMNMLTTVGSFIFAVGFAMLLVNVLVSLRRGAPAGANPWDAPTLEWAVSSPPPPYNFAVLPVIA |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length647
- Mass (Da)71,546
- Last updated2006-05-02 v1
- Checksum145CE06C66E206EF
Keywords
- Technical term