Q1YF42 · Q1YF42_AURMS

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site15-20substrate
Binding site47Mg2+ (UniProtKB | ChEBI)
Active site76Proton acceptor
Binding site76Mg2+ (UniProtKB | ChEBI)
Binding site77substrate
Binding site162-165substrate
Binding site185substrate
Binding site198-199substrate

GO annotations

AspectTerm
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      SI859A1_03339

Organism names

Accessions

  • Primary accession
    Q1YF42

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    214
  • Mass (Da)
    23,206
  • Last updated
    2006-05-02 v1
  • Checksum
    0C62521F67418450
MTRLDPKDGPLLVASHNIGKIWEIRELMEPFGFEVTSAKDKGLEDPEETGTTFEANAELKALAAMRATGLVSLSDDSGIAIDALNGDPGIYSARWGGPDRDFAMAMRNVEEKLQAAGATTPEQRRAKFVAVLCLADPAGGTHLFRGEVEGTIVWPPRGELGFGYDPIFLPDGSDRTFGEMMSAEKHAWKPGQPTAMSHRARAFQKFARDALGVE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAPJ01000007
EMBL· GenBank· DDBJ
EAS48703.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp