Q1YDX4 · Q1YDX4_AURMS

Function

function

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 1 Fe2+ ion per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site123Fe cation (UniProtKB | ChEBI)
Binding site127Fe cation (UniProtKB | ChEBI)
Binding site145-149substrate
Binding site178substrate
Binding site191substrate
Binding site195substrate
Binding site291substrate
Binding site319Fe cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioniron ion binding
Molecular FunctionN(6)-L-threonylcarbamoyladenine synthase activity
Biological ProcesstRNA threonylcarbamoyladenosine modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA N6-adenosine threonylcarbamoyltransferase
  • EC number
  • Alternative names
    • N6-L-threonylcarbamoyladenine synthase
      (t(6)A synthase
      )
    • t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD
    • tRNA threonylcarbamoyladenosine biosynthesis protein TsaD

Gene names

    • Name
      tsaD
    • ORF names
      SI859A1_03651

Organism names

Accessions

  • Primary accession
    Q1YDX4

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain36-326Gcp-like

Sequence similarities

Belongs to the KAE1 / TsaD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    367
  • Mass (Da)
    37,990
  • Last updated
    2006-05-02 v1
  • Checksum
    110BFAFE5862144F
MTPANPPRPLILGIETSCDETAASVVGRDDAGAPVIHSNVVLSQVEEHAAFGGVVPEIAARAHVEALDGIVKAAMDEAGIGFDELSAVAATTGPGLVGGLIVGAMTGKAIAAARRLPFLAINHLEGHALTPRLTDRLAYPYLLLLVSGGHSQIVLVRGLGAYERWGTTIDDALGEAFDKTAKLLGLPNPGGPHVERRAAAGDPKRFALPRPMKGNPRLDFSFSGLKTALRMAAQAAAPLSPTDVDDLCAGFQAAAADSLADRVGRALTQFRDRFPDLADPVLAVAGGVAANRAIRTALEAQTARTGVRLVAPPLALCTDNAAMIAYAGLERFEAGMVDGLDAPVRSRWPLDGDSAPMIGFGRRGAKA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAPJ01000010
EMBL· GenBank· DDBJ
EAS48484.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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