Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H.[...], Sugano S.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Genet. 36:40-45 (2004)Cited in99+99+
No title available.Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H.[...], Venter J.C.Cited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)Submission Submitted to EMBL/GenBank/DDBJ databases (JUL-2005)Cited in99+
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
The full-ORF clone resource of the German cDNA consortium.Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A.[...], Schupp I.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-405TissueMelanomaCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBMC Genomics 8:399-399 (2007)Cited in99+
SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway.Gu X., Orozco J.M., Saxton R.A., Condon K.J., Liu G.Y., Krawczyk P.A., Scaria S.M., Harper J.W., Gygi S.P., Sabatini D.M.View abstractCited forFUNCTION, INTERACTION WITH THE GATOR1 AND KICSTOR COMPLEXESCategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 358:813-818 (2017)Cited in3Mapped to52
Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.Shen K., Huang R.K., Brignole E.J., Condon K.J., Valenstein M.L., Chantranupong L., Bomaliyamu A., Choe A., Hong C.[...], Sabatini D.M.View abstractCited forINTERACTION WITH DEPDC5CategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 556:64-69 (2018)Cited in6
Molecular mechanism of S-adenosylmethionine sensing by SAMTOR in mTORC1 signaling.Tang X., Zhang Y., Wang G., Zhang C., Wang F., Shi J., Zhang T., Ding J.View abstractCited forFUNCTION, INTERACTION WITH THE GATOR1 AND KICSTOR COMPLEXES, MUTAGENESIS OF ARG-95; PHE-175; ASP-190 AND ASP-202CategoriesFunction, Disease & Variants, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCSci. Adv. 8:eabn3868-eabn3868 (2022)Cited in2
Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagBl) with remote similarity to the Ras-related GTPases.Schuermann A., Brauers A., Massmann S., Becker W., Joost H.-G.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9640251PubMedEurope PMCJ. Biol. Chem. 270:28982-28988 (1995)Cited in4Mapped to52
Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases.Shen K., Valenstein M.L., Gu X., Sabatini D.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9640251PubMedEurope PMCJ. Biol. Chem. 294:2970-2975 (2019)Cited in1Mapped to49
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.Wolfson R.L., Chantranupong L., Wyant G.A., Gu X., Orozco J.M., Shen K., Condon K.J., Petri S., Kedir J.[...], Sabatini D.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9640251PubMedEurope PMCNature 543:438-442 (2017)Cited in13Mapped to15
Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway.Gai Z., Wang Q., Yang C., Wang L., Deng W., Wu G.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9640251PubMedEurope PMCCell Discov 2:16051-16051 (2016)Mapped to50
Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling.Xia J., Wang R., Zhang T., Ding J.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9640251PubMedEurope PMCCell Discov 2:16035-16035 (2016)Mapped to50
Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.Saxton R.A., Chantranupong L., Knockenhauer K.E., Schwartz T.U., Sabatini D.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9640251PubMedEurope PMCNature 536:229-233 (2016)Cited in6Mapped to44
The CASTOR proteins are arginine sensors for the mTORC1 pathway.Chantranupong L., Scaria S.M., Saxton R.A., Gygi M.P., Shen K., Wyant G.A., Wang T., Harper J.W., Gygi S.P., Sabatini D.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9640251PubMedEurope PMCCell 165:153-164 (2016)Cited in7Mapped to44
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.Saxton R.A., Knockenhauer K.E., Wolfson R.L., Chantranupong L., Pacold M.E., Wang T., Schwartz T.U., Sabatini D.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9640251PubMedEurope PMCScience 351:53-58 (2016)Cited in3Mapped to47
Sestrin2 is a leucine sensor for the mTORC1 pathway.Wolfson R.L., Chantranupong L., Saxton R.A., Shen K., Scaria S.M., Cantor J.R., Sabatini D.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9640251PubMedEurope PMCScience 351:43-48 (2016)Cited in4Mapped to47
Sestrin2 inhibits mTORC1 through modulation of GATOR complexes.Kim J.S., Ro S.H., Kim M., Park H.W., Semple I.A., Park H., Cho U.S., Wang W., Guan K.L.[...], Lee J.H.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9640251PubMedEurope PMCSci Rep 5:9502-9502 (2015)Mapped to70
Sestrins inhibit mTORC1 kinase activation through the GATOR complex.Parmigiani A., Nourbakhsh A., Ding B., Wang W., Kim Y.C., Akopiants K., Guan K.L., Karin M., Budanov A.V.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9640251PubMedEurope PMCCell Rep. 9:1281-1291 (2014)Cited in7Mapped to43
The Sestrins interact with GATOR2 to negatively regulate the amino-acid- sensing pathway upstream of mTORC1.Chantranupong L., Wolfson R.L., Orozco J.M., Saxton R.A., Scaria S.M., Bar-Peled L., Spooner E., Isasa M., Gygi S.P., Sabatini D.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9640251PubMedEurope PMCCell Rep. 9:1-8 (2014)Cited in8Mapped to43
Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.Peng M., Yin N., Li M.O.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9640251PubMedEurope PMCCell 159:122-133 (2014)Cited in14Mapped to54
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.Bar-Peled L., Chantranupong L., Cherniack A.D., Chen W.W., Ottina K.A., Grabiner B.C., Spear E.D., Carter S.L., Meyerson M., Sabatini D.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-9640251PubMedEurope PMCScience 340:1100-1106 (2013)Cited in17Mapped to45
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.Rose J.E., Behm F.M., Drgon T., Johnson C., Uhl G.R.View abstractAnnotationClinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)CategoriesFunctionSourceGeneRif: 154743PubMedEurope PMCMol Med 16:247-253 (2010)Mapped to99+
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.Anney R.J., Lasky-Su J., O'Dushlaine C., Kenny E., Neale B.M., Mulligan A., Franke B., Zhou K., Chen W.[...], Gill M.View abstractAnnotationAssociated with PSYCH: Attention deficit hyperactivity disorder and conduct disorder.CategoriesDisease & VariantsSourceGAD:597636PubMedEurope PMCAm J Med Genet B Neuropsychiatr Genet 147B:1369-1378 (2008)Mapped to92