Q1RMJ6 · RHOC_BOVIN

  • Protein
    Rho-related GTP-binding protein RhoC
  • Gene
    RHOC
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity).

Features

Showing features for binding site.

119320406080100120140160180
TypeIDPosition(s)Description
Binding site12-19GTP (UniProtKB | ChEBI)
Binding site59-63GTP (UniProtKB | ChEBI)
Binding site117-120GTP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcleavage furrow
Cellular Componentcytosol
Cellular Componentnucleus
Cellular Componentplasma membrane
Cellular Componentstereocilium
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionprotein kinase binding
Biological Processactin filament organization
Biological Processapical junction assembly
Biological Processmitotic cytokinesis
Biological Processpositive regulation of cell migration
Biological Processpositive regulation of protein-containing complex assembly
Biological Processpositive regulation of stress fiber assembly
Biological Processregulation of actin cytoskeleton organization
Biological Processsignal transduction
Biological Processskeletal muscle satellite cell migration
Biological Processsmall GTPase-mediated signal transduction
Biological Processwound healing, spreading of cells

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Rho-related GTP-binding protein RhoC

Gene names

    • Name
      RHOC
    • Synonyms
      ARHC

Organism names

  • Taxonomic identifier
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    Q1RMJ6

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Lipid-anchor
Cleavage furrow
Note: Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue, lipidation, propeptide.

TypeIDPosition(s)Description
ChainPRO_00002657281-190
Modified residue190Cysteine methyl ester
Lipidation190S-geranylgeranyl cysteine
PropeptidePRO_0000265729191-193Removed in mature form

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with RTKN. Interacts with AKAP13. Interacts with DIAPH1. Interacts with PKN2. Interacts with ROCK1 and ROCK2. Interacts with ARHGDIA. Interacts with RIPOR1.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif34-42Effector region

Sequence similarities

Belongs to the small GTPase superfamily. Rho family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    193
  • Mass (Da)
    22,006
  • Last updated
    2006-05-16 v1
  • Checksum
    A193DA581560F131
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQVRKNKRRRGCPIL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC114859
EMBL· GenBank· DDBJ
AAI14860.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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