Q1RG18 · PYRH_ECOUT
- ProteinUridylate kinase
- GenepyrH
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids241 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reversible phosphorylation of UMP to UDP.
Catalytic activity
- ATP + UMP = ADP + UDP
Activity regulation
Allosterically activated by GTP. Inhibited by UTP.
Pathway
Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 15-18 | ATP (UniProtKB | ChEBI) | ||||
Sequence: KLSG | ||||||
Binding site | 57 | UMP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 58 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 62 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 77 | UMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 138-145 | UMP (UniProtKB | ChEBI) | ||||
Sequence: TGNPFFTT | ||||||
Binding site | 165 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 171 | ATP (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 174 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | UMP kinase activity | |
Biological Process | 'de novo' CTP biosynthetic process | |
Biological Process | UDP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUridylate kinase
- EC number
- Short namesUK
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionQ1RG18
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000053923 | 1-241 | Uridylate kinase | |||
Sequence: MATNAKPVYKRILLKLSGEALQGTEGFGIDASILDRMAQEIKELVELGIQVGVVIGGGNLFRGAGLAKAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDSYSWAEAISLLRNNRVVILSAGTGNPFFTTDSAACLRGIEIEADVVLKATKVDGVFTADPAKDPTATMYEQLTYSEVLEKELKVMDLAAFTLARDHKLPIRVFNMNKPGALRRVVMGEKEGTLITE |
Interaction
Subunit
Homohexamer.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length241
- Mass (Da)25,970
- Last updated2006-05-16 v1
- Checksum82EFA75F7226E201
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000243 EMBL· GenBank· DDBJ | ABE05696.1 EMBL· GenBank· DDBJ | Genomic DNA |