Q1RG18 · PYRH_ECOUT

Function

function

Catalyzes the reversible phosphorylation of UMP to UDP.

Catalytic activity

Activity regulation

Allosterically activated by GTP. Inhibited by UTP.

Pathway

Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.

Features

Showing features for binding site.

124120406080100120140160180200220240
TypeIDPosition(s)Description
Binding site15-18ATP (UniProtKB | ChEBI)
Binding site57UMP (UniProtKB | ChEBI)
Binding site58ATP (UniProtKB | ChEBI)
Binding site62ATP (UniProtKB | ChEBI)
Binding site77UMP (UniProtKB | ChEBI)
Binding site138-145UMP (UniProtKB | ChEBI)
Binding site165ATP (UniProtKB | ChEBI)
Binding site171ATP (UniProtKB | ChEBI)
Binding site174ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular FunctionUMP kinase activity
Biological Process'de novo' CTP biosynthetic process
Biological ProcessUDP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uridylate kinase
  • EC number
  • Short names
    UK
  • Alternative names
    • Uridine monophosphate kinase
      (UMP kinase
      ; UMPK
      )

Gene names

    • Name
      pyrH
    • Ordered locus names
      UTI89_C0186

Organism names

Accessions

  • Primary accession
    Q1RG18

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000539231-241Uridylate kinase

Interaction

Subunit

Homohexamer.

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region23-28Involved in allosteric activation by GTP

Sequence similarities

Belongs to the UMP kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    241
  • Mass (Da)
    25,970
  • Last updated
    2006-05-16 v1
  • Checksum
    82EFA75F7226E201
MATNAKPVYKRILLKLSGEALQGTEGFGIDASILDRMAQEIKELVELGIQVGVVIGGGNLFRGAGLAKAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDSYSWAEAISLLRNNRVVILSAGTGNPFFTTDSAACLRGIEIEADVVLKATKVDGVFTADPAKDPTATMYEQLTYSEVLEKELKVMDLAAFTLARDHKLPIRVFNMNKPGALRRVVMGEKEGTLITE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000243
EMBL· GenBank· DDBJ
ABE05696.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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