Q1R8U3 · PTYBC_ECOUT

Function

function

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring.

Catalytic activity

Features

Showing features for active site.

147450100150200250300350400450
TypeIDPosition(s)Description
Active site29Phosphocysteine intermediate; for EIIB activity

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionkinase activity
Molecular Functionprotein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Molecular Functionprotein-phosphocysteine-N-acetylmuramate phosphotransferase system transporter activity
Biological Processphosphoenolpyruvate-dependent sugar phosphotransferase system
Biological Processphosphorylation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    PTS system N-acetylmuramic acid-specific EIIBC component
  • Alternative names
    • EIIBC-MurNAc

Including 2 domains:

  • Recommended name
    N-acetylmuramic acid-specific phosphotransferase enzyme IIB component
  • EC number
  • Alternative names
    • PTS system N-acetylmuramic acid-specific EIIB component
  • Recommended name
    N-acetylmuramic acid permease IIC component
  • Alternative names
    • PTS system N-acetylmuramic acid-specific EIIC component

Gene names

    • Name
      murP
    • Ordered locus names
      UTI89_C2761

Organism names

Accessions

  • Primary accession
    Q1R8U3

Proteomes

Subcellular Location

Cell inner membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-123Cytoplasmic
Transmembrane124-144Helical
Topological domain145-157Periplasmic
Transmembrane158-178Helical
Topological domain179-180Cytoplasmic
Transmembrane181-201Helical
Topological domain202-217Periplasmic
Transmembrane218-238Helical
Topological domain239-260Cytoplasmic
Transmembrane261-281Helical
Topological domain282-301Periplasmic
Transmembrane302-322Helical
Topological domain323-334Cytoplasmic
Transmembrane335-355Helical
Topological domain356-368Periplasmic
Transmembrane369-389Helical
Topological domain390-393Cytoplasmic
Transmembrane394-414Helical
Topological domain415-440Periplasmic
Transmembrane441-461Helical
Topological domain462-474Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002489551-474PTS system N-acetylmuramic acid-specific EIIBC component

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-89PTS EIIB type-1
Domain115-474PTS EIIC type-1

Domain

The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.
The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    474
  • Mass (Da)
    49,815
  • Last updated
    2006-05-16 v1
  • Checksum
    76E0204B5F0B8AC7
MAKEISSELLNTILTRVGGPGNIASCGNCMTRLRLGVHDSSLVDPDIKTLEGVKGVILTSDQVQVVFGPGKAHRAAKAMSELLGEAPVQDAAEIAAQNKRQLKARQTSGVQQFLAKFATIFTPLIPGFIAAGLLLGIATLIATVMHVTADAQGTLPDALNFMKVFSKGLFTFLVILVGYNAAQAFGGTGVNGAIIAALFLLGYNPTATTGYYAGFHDFFGLPIDPRGNIIGVLIAAWACARIEGMVRRFMPDDLDMLLTSLITLLITATLAYLIIMPLGGWLFEGMSWLFMHLNSNPLGCAVLAGLFLIAVVFGVHQGFIPVYLALMDSQGFNSLFPILSMAGAGQVGAALALYWRAQPHSALRSQVRGAIIPGLLGVGEPLIYGVTLPRMKPFVTACLGGAAGGLFIGLIAWWGLPMGLNSAFGPSGLVALPLMTSAQGILPAMAVYAGGILVAWVSGFIFTTLFGCRNVNLD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000243
EMBL· GenBank· DDBJ
ABE08221.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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