Q1R6B5 · NANA_ECOUT

Function

function

Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.

Catalytic activity

Pathway

Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 1/5.

Features

Showing features for binding site, active site.

129720406080100120140160180200220240260280
Type
IDPosition(s)Description
Binding site47aceneuramate (UniProtKB | ChEBI)
Binding site48aceneuramate (UniProtKB | ChEBI)
Active site137Proton donor
Active site165Schiff-base intermediate with substrate
Binding site167aceneuramate (UniProtKB | ChEBI)
Binding site189aceneuramate (UniProtKB | ChEBI)
Binding site191aceneuramate (UniProtKB | ChEBI)
Binding site192aceneuramate (UniProtKB | ChEBI)
Binding site208aceneuramate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionN-acetylneuraminate lyase activity
Biological Processcarbohydrate metabolic process
Biological ProcessN-acetylneuraminate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N-acetylneuraminate lyase
  • EC number
  • Short names
    NAL
    ; Neu5Ac lyase
  • Alternative names
    • N-acetylneuraminate pyruvate-lyase
    • N-acetylneuraminic acid aldolase
    • Sialate lyase
    • Sialic acid aldolase
    • Sialic acid lyase

Gene names

    • Name
      nanA
    • Ordered locus names
      UTI89_C3655

Organism names

Accessions

  • Primary accession
    Q1R6B5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000669271-297N-acetylneuraminate lyase

Interaction

Subunit

Homotetramer.

Structure

Family & Domains

Sequence similarities

Belongs to the DapA family. NanA subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    297
  • Mass (Da)
    32,593
  • Last updated
    2006-05-16 v1
  • Checksum
    BA9F30B4A7624167
MATNLRGVMAALLTPFDQQQALDKASLRRLVQFNIQQGIDGLYVGGSTGEAFVQSLSEREQVLEIVAEEAKGKIKLIAHVGCVSTAESQQLAASAKRYGFDAVSAVTPFYYPFSFEEHCDHYRAIIDSADGLPMVVYNIPALSGVKLTLDQINTLVTLPGVGALKQTSGDLYQMEQIRREHPDLVLYNGYDEIFASGLLAGADGGIGSTYNIMGWRYQGIVKALKEGDIQTAQKLQTECNKVIDLLIKTGVFRGLKTVLHYMDVVSVPLCRKPFGPVDEKYLPELKALAQQLMQERG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000243
EMBL· GenBank· DDBJ
ABE09099.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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