Q1R3T1 · ACEK_ECOUT

Function

function

Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.

Catalytic activity

Features

Showing features for binding site, active site.

157450100150200250300350400450500550
Type
IDPosition(s)Description
Binding site315-321ATP (UniProtKB | ChEBI)
Binding site336ATP (UniProtKB | ChEBI)
Active site371

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function[isocitrate dehydrogenase (NADP+)] kinase activity
Molecular FunctionAMP binding
Molecular FunctionATP binding
Molecular Functionphosphoprotein phosphatase activity
Molecular Functionprotein serine/threonine kinase activity
Biological Processglucose metabolic process
Biological Processglyoxylate cycle
Biological Processpeptidyl-serine phosphorylation
Biological Processprotein dephosphorylation
Biological Processregulation of catalytic activity
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Isocitrate dehydrogenase kinase/phosphatase
  • EC number
  • Short names
    IDH kinase/phosphatase
    ; IDHK/P

Gene names

    • Name
      aceK
    • Ordered locus names
      UTI89_C4575

Organism names

Accessions

  • Primary accession
    Q1R3T1

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002591501-574Isocitrate dehydrogenase kinase/phosphatase

Structure

Family & Domains

Sequence similarities

Belongs to the AceK family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    574
  • Mass (Da)
    67,206
  • Last updated
    2006-05-16 v1
  • Checksum
    8285CBDABE00D7EB
MPRGLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKNRIHLYDHHVGLVVEQLRCITNGQSTDAAFLLRVKEHYTRLLPDYPRFEIAESFFNSVYCRLFDHRSLTPERLFIFSSQPERRFRTIPRPLAKDFHPDHGWESLLMRVISDLPLRLRWQNKSRDIHYIVRHLTETLGTDNLAESHLQVANELFYRNKAAWLVGKLITPSGTLPFLLPIHQTDDGELFIDTCLTTTAEASIVFGFARSYFMVYAPLPAALVEWLREILPGKTTAELYMAIGCQKHAKTESYREYLVYLQGCNEQFIEAPGIRGMVMLVFTLPGFDRVFKVIKDRFAPQKEMSAAHVRACYQLVKEHDRVGRMADTQEFENFVLEKRHISPALMELLLQEAAEKITDLGEQIVIRHLYIERRMVPLNIWLEQVEGQQLRDAIEEYGNAIRQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEICYMTEVNFRDIPLPRYPEDELASEPWYSVSPGDVFPEEFRHWLCADPRIGPLFEEMHADLFRADYWRALQNRIREGHVEDVYAYRRRQRFSVRFV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000243
EMBL· GenBank· DDBJ
ABE09983.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp