Q1QX63 · Q1QX63_CHRSD

Function

function

Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.

Catalytic activity

  • Endonucleolytic cleavage of single-stranded RNA in A- and U-rich regions.
    EC:3.1.26.12 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per homotetramer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site300Mg2+ (UniProtKB | ChEBI); catalytic
Binding site343Mg2+ (UniProtKB | ChEBI); catalytic
Binding site401Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site404Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytoplasmic side of plasma membrane
Molecular Functionmagnesium ion binding
Molecular Functionribonuclease E activity
Molecular FunctionRNA endonuclease activity
Molecular FunctionrRNA binding
Molecular FunctiontRNA binding
Molecular Functionzinc ion binding
Biological ProcessmRNA catabolic process
Biological ProcessrRNA processing
Biological ProcesstRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonuclease E
  • EC number
  • Short names
    RNase E

Gene names

    • Name
      rne
    • Ordered locus names
      Csal_1592

Organism names

Accessions

  • Primary accession
    Q1QX63

Proteomes

Subcellular Location

Cytoplasm
Cell inner membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Within the RNA degradosome, RNase E assembles into a homotetramer formed by a dimer of dimers.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain39-117S1 motif
Region401-404Required for zinc-mediated homotetramerization and catalytic activity
Region487-565Disordered
Compositional bias496-511Polar residues
Region579-1175Disordered
Compositional bias582-627Polar residues
Compositional bias628-675Basic and acidic residues
Compositional bias676-694Polar residues
Compositional bias695-747Basic and acidic residues
Compositional bias753-774Polar residues
Compositional bias804-841Polar residues
Compositional bias985-1013Polar residues
Compositional bias1024-1145Polar residues
Compositional bias1150-1175Basic and acidic residues

Sequence similarities

Belongs to the RNase E/G family. RNase E subfamily.
Belongs to the RNase E/G family. RNase G subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,175
  • Mass (Da)
    126,086
  • Last updated
    2006-05-16 v1
  • Checksum
    1A1276DB1A134AE5
MKRMLINATQPEELRVALVDGQRLYDLDIESGAREQKKANIYRGRITRIEPSLEAAFVDFGAERHGFLPLKEISREYFTKEPSGRPNIKEVLKEGQEVIVQVDKEERGNKGAALTTFISLAGRFLVLMPNNPRAGGISRRIEGDDRAQLKDAMGQLTVPDKMGVIVRTAGIGRSPEELQWDMDYLVQVWEAITEEAGKRSAPFLIYRESNVIIRAMRDYLRHDIGEVLIDSPEVHEEALHFIRQVMPSYQNKIKLYADDVPLFSRFQIESQIETAYQREVKLPSGGAVVIDHTEALVSIDINSARATRGSDIEETALQTNLEAADEIARQLRLRDIGGLVVIDFIDMTPAKNQREVENRVRDALKLDRARVQIGRISRFGLMEMSRQRLRPSLGETSGVVCPRCNGQGTIRDVRSISLSIMRLIEEEAMKERSSQIRAILPVPVATYLLNEKRSVLNDIEQRQGVQVVLLPNPDMDTPHYDVQRLRDDQVSEEDGQRSSFELPTTTELTQEPDPALDKPMQRAEAAVKSVAHNAPAPTSLQHDTAPPATPTPAPAADAPASTPAESGLFSRLVKGLGKLLNGEDSTSPSKQSNDQAQQSGASKTTSEARRQRQGSDQSSTSRSDGDTGSKQRQNDDSRRDAGSGNGRGGNRRRRNGEESQDRQASRSDNRDGNRSSRSSRGNGGNGGRNENARGSGGSDKGRQDTRSDSRNDARNDSRSDSRNDGRNATKGGNKPREENKDAKAGKPKAETPSQSAPDKQATSDKQTTPSQDDAPKSDGKPKRTRNNPRQRSRKHAVNPNAVAEQEKLQAQQEAEGATSTGDNTQPQATAAQASPEAEPTSTAPSDAPAAAAAPTDEDESSQAAAAKSSQDAKSRNAKSKRSRNASKPARTASETADAAPQGKTSADAPETAAEAPSQPREAAAAAQPADSATSEAPATANADTRASAPAPSADDASALSEPKAPRDATPSAEAPADETSASDAPRGEVSDSQPASSAAADEATSTGRDTVEQEAATPVTKDEAATAPATSSADADVDTRQDAASSTATPQDDTLATPASQAEQKASTDAPAPQAEPTTPAAAAASSSDEQAPAEVSESQPQAEPKAPSDASATSSEEKASTETPAPQPEQTASTEASEPQQATASAPRRRRRAHNDPREQRRLQENLFRGDDNA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias496-511Polar residues
Compositional bias582-627Polar residues
Compositional bias628-675Basic and acidic residues
Compositional bias676-694Polar residues
Compositional bias695-747Basic and acidic residues
Compositional bias753-774Polar residues
Compositional bias804-841Polar residues
Compositional bias985-1013Polar residues
Compositional bias1024-1145Polar residues
Compositional bias1150-1175Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000285
EMBL· GenBank· DDBJ
ABE58945.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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