Q1QSS9 · DTD_CHRSD

Function

function

An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionD-aminoacyl-tRNA deacylase activity
Molecular FunctionGly-tRNA(Ala) hydrolase activity
Molecular FunctionSer(Gly)-tRNA(Ala) hydrolase activity
Molecular FunctiontRNA binding
Biological ProcessD-amino acid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    D-aminoacyl-tRNA deacylase
  • EC number
  • Short names
    DTD
  • Alternative names
    • Gly-tRNA(Ala) deacylase

Gene names

    • Name
      dtd
    • Ordered locus names
      Csal_3135

Organism names

Accessions

  • Primary accession
    Q1QSS9

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002592701-145D-aminoacyl-tRNA deacylase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif137-138Gly-cisPro motif, important for rejection of L-amino acids

Domain

A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.

Sequence similarities

Belongs to the DTD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    145
  • Mass (Da)
    15,584
  • Last updated
    2006-05-16 v1
  • Checksum
    DD24CF24F469765A
MRAVIQRVRHAGVDVDARTTGAIEQGLMVLVGVAPDDTQTRADKMLHKLLGLRVFSDEAGKMNLNVQQVEGGLLLVPQFTLMANTTKGLRPGFDGAAPPAHGEALFDYLVAQARHAWPYVATGEFGADMQVSLLNDGPVTFIVET

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000285
EMBL· GenBank· DDBJ
ABE60479.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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