Q1QPR8 · HGD_NITHX
- ProteinHomogentisate 1,2-dioxygenase
- GenehmgA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids448 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
Catalytic activity
- homogentisate + O2 = 4-maleylacetoacetate + H+
Cofactor
Pathway
Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 303 | Proton acceptor | |||
Binding site | 346 | Fe cation (UniProtKB | ChEBI) | |||
Binding site | 352 | Fe cation (UniProtKB | ChEBI) | |||
Binding site | 361 | homogentisate (UniProtKB | ChEBI) | |||
Binding site | 382 | Fe cation (UniProtKB | ChEBI) | |||
Binding site | 382 | homogentisate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | homogentisate 1,2-dioxygenase activity | |
Molecular Function | iron ion binding | |
Biological Process | L-phenylalanine catabolic process | |
Biological Process | tyrosine catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHomogentisate 1,2-dioxygenase
- EC number
- Short namesHGDO
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Nitrobacteraceae > Nitrobacter
Accessions
- Primary accessionQ1QPR8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000019531 | 1-448 | Homogentisate 1,2-dioxygenase | ||
Interaction
Structure
Sequence
- Sequence statusComplete
- Length448
- Mass (Da)49,674
- Last updated2006-05-16 v1
- MD5 Checksum171614AA1E4355AF32650C8ED61B9252
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000319 EMBL· GenBank· DDBJ | ABE61779.1 EMBL· GenBank· DDBJ | Genomic DNA |