Q1Q4C6 · Q1Q4C6_KUEST

  • Protein
    CRISPR-associated endoribonuclease Cas2
  • Gene
    cas
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

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MYVVVVYDVDQKRCTKMLKLCRGYLHHIQNSVFEGEITEARLEELKIKAKKIMNEEDKDSLIVFKSRNEKWLDKEIVGFDKRPVDNIL
TypeIDPosition(s)Description
Binding site8Mg2+ (UniProtKB | ChEBI); catalytic

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionmetal ion binding
Molecular FunctionRNA endonuclease activity
Biological Processdefense response to virus
Biological Processmaintenance of CRISPR repeat elements

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    CRISPR-associated endoribonuclease Cas2
  • EC number

Gene names

    • Name
      cas
    • Synonyms
      cas2
    • ORF names
      KsCSTR_33710
      , KSMBR1_0473
      , kuste4106

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • Kuenenia_mbr1_ru-nijmegen
    • CSTR1
  • Taxonomic lineage
    Bacteria > Planctomycetota > Candidatus Brocadiia > Candidatus Brocadiales > Candidatus Brocadiaceae > Candidatus Kuenenia

Accessions

  • Primary accession
    Q1Q4C6

Proteomes

    • Identifier
    • Component
      Chromosome Kuenenia_stuttgartiensis_MBR1

Interaction

Subunit

Homodimer, forms a heterotetramer with a Cas1 homodimer.

Family & Domains

Sequence similarities

Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    88
  • Mass (Da)
    10,472
  • Last updated
    2006-05-16 v1
  • Checksum
    8BD726827C06B076
MYVVVVYDVDQKRCTKMLKLCRGYLHHIQNSVFEGEITEARLEELKIKAKKIMNEEDKDSLIVFKSRNEKWLDKEIVGFDKRPVDNIL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CT573071
EMBL· GenBank· DDBJ
CAJ74868.1
EMBL· GenBank· DDBJ
Genomic DNA
CP049055
EMBL· GenBank· DDBJ
QII12750.1
EMBL· GenBank· DDBJ
Genomic DNA
LT934425
EMBL· GenBank· DDBJ
SOH02987.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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