Q1MTB5 · Q1MTB5_DANRE

Function

function

The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN. Both activities occur in the reticulum endoplasmic. Once cleaved, ShhC is degraded in the endoplasmic reticulum.

Protein hedgehog N-product

The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

Protein hedgehog

The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.

Catalytic activity

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site89Ca2+ 1 (UniProtKB | ChEBI)
Binding site90Ca2+ 2 (UniProtKB | ChEBI)
Binding site90Ca2+ 1 (UniProtKB | ChEBI)
Binding site95Ca2+ 1 (UniProtKB | ChEBI)
Binding site125Ca2+ 1 (UniProtKB | ChEBI)
Binding site126Ca2+ 1 (UniProtKB | ChEBI)
Binding site126Ca2+ 2 (UniProtKB | ChEBI)
Binding site129Ca2+ 2 (UniProtKB | ChEBI)
Binding site131Ca2+ 2 (UniProtKB | ChEBI)
Binding site140Zn2+ (UniProtKB | ChEBI)
Binding site147Zn2+ (UniProtKB | ChEBI)
Binding site182Zn2+ (UniProtKB | ChEBI)
Site197-198Cleavage; by autolysis
Site243Involved in cholesterol transfer
Site267Involved in auto-cleavage
Site270Essential for auto-cleavage

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentGolgi membrane
Cellular Componentplasma membrane
Molecular Functionmetal ion binding
Molecular Functionpeptidase activity
Molecular Functiontransferase activity
Biological Processanimal organ development
Biological Processcell development
Biological Processcell fate commitment
Biological Processcell-cell signaling
Biological Processcentral nervous system development
Biological Processintein-mediated protein splicing
Biological Processneuron differentiation
Biological Processpattern specification process
Biological Processprotein autoprocessing
Biological Processregulation of cell population proliferation
Biological Processregulation of developmental process
Biological Processtissue development
Biological Processtube development

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Hedgehog protein

Gene names

    • Name
      shha
    • ORF names
      CH211-150E22.3-001

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q1MTB5

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane

Sonic hedgehog protein

Endoplasmic reticulum membrane
Golgi apparatus membrane

Protein hedgehog N-product

Cell membrane
; Lipid-anchor

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-23
ChainPRO_501013657324-418Hedgehog protein

Keywords

Interaction

Subunit

Multimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain196-303Hint
Domain305-349Hint

Sequence similarities

Belongs to the hedgehog family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    418
  • Mass (Da)
    46,403
  • Last updated
    2006-05-30 v1
  • Checksum
    CF000AFFFD2F5795
MRLLTRVLLVSLLTLSLVVSGLACGPGRGYGRRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNSLAISVMNHWPGVKLRVTEGWDEDGHHFEESLHYEGRAVDITTSDRDKSKYGTLSRLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSALVSLQDGGQKAVKDLNPGDKVLAADSAGNLVFSDFIMFTDRDSTTRRVFYVIETQEPVEKITLTAAHLLFVLDNSTEDLHTMTAAYASSVRAGQKVMVVDDSGQLKSVIVQRIYTEEQRGSFAPVTAHGTIVVDRILASCYAVIEDQGLAHLAFAPARLYYYVSSFLFPQNSSSRSNATLQQEGVHWYSRLLYQMGTWLLDSNMLHPLGMSVNSS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC162395
EMBL· GenBank· DDBJ
AAI62395.1
EMBL· GenBank· DDBJ
mRNA
AL929206
EMBL· GenBank· DDBJ
CAK04143.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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