Q1MSW8 · Q1MSW8_HUMAN
- ProteinCellular tumor antigen p53
- GeneTP53
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids343 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | centrosome | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | mitochondrial matrix | |
Cellular Component | PML body | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | apoptotic process | |
Biological Process | positive regulation of DNA-templated transcription | |
Biological Process | rhythmic process |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCellular tumor antigen p53
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ1MSW8
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Cross-link | 291 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||||
Sequence: K |
Keywords
- PTM
Proteomic databases
Interaction
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-30 | p53 transactivation | ||||
Sequence: SDPSVEPPLSQETFSDLWKLLPENN | ||||||
Domain | 35-59 | Cellular tumor antigen p53 transactivation | ||||
Sequence: LPSQAMDDLMLSPDDIEQWFTEDPG | ||||||
Region | 47-97 | Disordered | ||||
Sequence: PDDIEQWFTEDPGPDEAPRMPEAAPRVAPAPAAPTPAAPAPAPSWPLSSSV | ||||||
Compositional bias | 70-92 | Pro residues | ||||
Sequence: APRVAPAPAAPTPAAPAPAPSWP | ||||||
Domain | 100-288 | p53 DNA-binding | ||||
Sequence: QKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEEN | ||||||
Compositional bias | 282-301 | Basic and acidic residues | ||||
Sequence: RRTEEENLRKKGEPHHELPP | ||||||
Region | 282-343 | Disordered | ||||
Sequence: RRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQKTFPARHGGSHL | ||||||
Compositional bias | 305-319 | Polar residues | ||||
Sequence: KRALPNNTSSSPQPK |
Sequence similarities
Belongs to the p53 family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length343
- Mass (Da)37,993
- Last updated2006-05-30 v1
- ChecksumE063D90FB1019883
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: M | ||||||
Compositional bias | 70-92 | Pro residues | ||||
Sequence: APRVAPAPAAPTPAAPAPAPSWP | ||||||
Compositional bias | 282-301 | Basic and acidic residues | ||||
Sequence: RRTEEENLRKKGEPHHELPP | ||||||
Compositional bias | 305-319 | Polar residues | ||||
Sequence: KRALPNNTSSSPQPK | ||||||
Non-terminal residue | 343 | |||||
Sequence: L |