Q1MSW8 · Q1MSW8_HUMAN

  • Protein
    Cellular tumor antigen p53
  • Gene
    TP53
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for site, binding site.

134350100150200250300
TypeIDPosition(s)Description
Site120Interaction with DNA
Binding site176Zn2+ (UniProtKB | ChEBI)
Binding site179Zn2+ (UniProtKB | ChEBI)
Binding site238Zn2+ (UniProtKB | ChEBI)
Binding site242Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcentrosome
Cellular Componentendoplasmic reticulum
Cellular Componentmitochondrial matrix
Cellular ComponentPML body
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processapoptotic process
Biological Processpositive regulation of DNA-templated transcription
Biological Processrhythmic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cellular tumor antigen p53

Gene names

    • Name
      TP53

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q1MSW8

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for cross-link.

TypeIDPosition(s)Description
Cross-link291Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Keywords

Proteomic databases

Interaction

Subunit

Binds DNA as a homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain6-30p53 transactivation
Domain35-59Cellular tumor antigen p53 transactivation
Region47-97Disordered
Compositional bias70-92Pro residues
Domain100-288p53 DNA-binding
Compositional bias282-301Basic and acidic residues
Region282-343Disordered
Compositional bias305-319Polar residues

Sequence similarities

Belongs to the p53 family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    343
  • Mass (Da)
    37,993
  • Last updated
    2006-05-30 v1
  • Checksum
    E063D90FB1019883
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPRVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQKTFPARHGGSHL

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias70-92Pro residues
Compositional bias282-301Basic and acidic residues
Compositional bias305-319Polar residues
Non-terminal residue343

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EF101868
EMBL· GenBank· DDBJ
ABL09847.1
EMBL· GenBank· DDBJ
mRNA
AM076972
EMBL· GenBank· DDBJ
CAJ28923.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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