Q1LX51 · WEE2_DANRE

Function

function

Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits cdk1 and acts as a key regulator of meiosis. Required to maintain meiotic arrest in oocytes by phosphorylating cdk1 at 'Tyr-15', leading to inhibit cdk1 activity and prevent meiotic reentry (By similarity).

Catalytic activity

Features

Showing features for binding site, active site.

153250100150200250300350400450500
TypeIDPosition(s)Description
Binding site194-202ATP (UniProtKB | ChEBI)
Binding site217ATP (UniProtKB | ChEBI)
Active site315Proton acceptor
Binding site320Mg2+ (UniProtKB | ChEBI)
Binding site354Mg2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionnon-membrane spanning protein tyrosine kinase activity
Molecular Functionprotein tyrosine kinase activity
Biological Processmeiotic cell cycle
Biological Processmitotic cell cycle
Biological Processregulation of meiosis I

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Wee1-like protein kinase 2
  • EC number
  • Alternative names
    • Wee1-like protein kinase 1B
    • Wee1B kinase

Gene names

    • Name
      wee2
    • Synonyms
      wee1b
    • ORF names
      si:ch211-238n5.5

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q1LX51
  • Secondary accessions
    • A4IFZ5
    • Q1LX50
    • Q32PP5

Proteomes

    • Identifier
    • Component
      Alternate scaffold 18, Chromosome 18

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004095281-532Wee1-like protein kinase 2

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain, coiled coil.

TypeIDPosition(s)Description
Region123-166Disordered
Compositional bias132-161Basic and acidic residues
Domain188-465Protein kinase
Coiled coil469-495

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q1LX51-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    532
  • Mass (Da)
    59,774
  • Last updated
    2011-05-31 v2
  • Checksum
    2192E4A0F6113D3C
MKWSEMASVNATQQHLNFSSSWEEDSSDNSFDEWTHKSVPLRSPCRTPRIQRHRNRSITVSPSVPTSPIPYAAWKKLRLCDSPSTPKSLLSKSTMPCSSSKTCRSQRFLRLSTAFERVPSVNINPFTPDTVRRNSEHYKRKSQRSDDDEDYGPRSKEIQNSSEDESFFLPSKRPAVSARMLSRYESEFLELACIGVGEFGSVYRCVKRLDGCMYAIKRSRRPIAGSANEQLALKEVYAHAVLGHHPHVVRYYSAWAEDDHMIIQNEYCDGGSLHDAITEKREQGEFFSVPELRDLLLQVSMGLKYIHNSGLVHLDIKPSNIFICRRSTLSAGGEGDSEEEDESHSSGVVYKIGDLGHVTSISSPQVEEGDSRFLAYEVLREDYTHLPKADIFALGLTVLLAAGASPLPQNGDDWHRLRQGELPNLPHELPALFKDLLKSLLDPDPTARPSATALCRHDVLCKERAGKLATQLRKELNVEKFRTAMLERELKEARLAATSPQQSCQPGSLPKAKRKLVGRNVARSVSFGFPGY

Q1LX51-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-5: Missing

Features

Showing features for alternative sequence, sequence conflict, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0413251-5in isoform 2
Sequence conflict17in Ref. 2; AAI08039
Sequence conflict37in Ref. 2; AAI34854
Sequence conflict102in Ref. 2; AAI08039/AAI34854
Compositional bias132-161Basic and acidic residues
Sequence conflict424in Ref. 2; AAI08039/AAI34854
Sequence conflict461in Ref. 2; AAI08039

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX470166
EMBL· GenBank· DDBJ
CAK04661.1
EMBL· GenBank· DDBJ
Genomic DNA
BX470166
EMBL· GenBank· DDBJ
CAK04662.1
EMBL· GenBank· DDBJ
Genomic DNA
BC108038
EMBL· GenBank· DDBJ
AAI08039.1
EMBL· GenBank· DDBJ
mRNA
BC134853
EMBL· GenBank· DDBJ
AAI34854.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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