Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

Q1LUI2 · HDDC2_DANRE

Function

function

Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 divalent metal cations (By similarity).
Shows activity with Mn2+, Co2+ and Mg2+ but shows no activity with Zn2+ (By similarity).

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site36a divalent metal cation 1 (UniProtKB | ChEBI)
Binding site64a divalent metal cation 1 (UniProtKB | ChEBI)
Binding site65a divalent metal cation 1 (UniProtKB | ChEBI)
Binding site68a divalent metal cation 2 (UniProtKB | ChEBI)
Binding site73a divalent metal cation 2 (UniProtKB | ChEBI)
Binding site74a divalent metal cation 2 (UniProtKB | ChEBI)
Binding site130a divalent metal cation 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function5'-deoxynucleotidase activity
Molecular Functionmetal ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5'-deoxynucleotidase HDDC2
  • EC number
  • Alternative names
    • HD domain-containing protein 2

Gene names

    • Name
      hddc2
    • ORF names
      si:ch211-208c9.2, zgc:112330

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q1LUI2
  • Secondary accessions
    • Q502C2

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003113911-2005'-deoxynucleotidase HDDC2

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain33-135HD

Sequence similarities

Belongs to the HDDC2 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    200
  • Mass (Da)
    22,919
  • Last updated
    2006-05-30 v1
  • MD5 Checksum
    374157A646DFC7D7E1CAFFDA12043EC5
MDNMLQFMKLVGQLKRVPRTGWVYRNIKQPESVSDHMYRMSMMALTIQDISVNKERCMKLALVHDLAECIVGDIAPADNVSKAEKHRREKDAMVHITGLLDDGLRKEIYNLWEEYETQSSPEAKLVKELDNLEMIIQAHEYEELEGKPGRLQEFFVSTEGKFHHPEVLGLLKSLNEERARHIAAGGEKTTDTDSLTLAKP

Sequence caution

The sequence AAH95766.1 differs from that shown. Reason: Erroneous initiation

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX936317
EMBL· GenBank· DDBJ
CAK04454.1
EMBL· GenBank· DDBJ
Genomic DNA
BC095766
EMBL· GenBank· DDBJ
AAH95766.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help