Q1LUI2 · HDDC2_DANRE
- Protein5'-deoxynucleotidase HDDC2
- Genehddc2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids200 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
Catalytic activity
- a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate
Cofactor
Co2+ (UniProtKB | Rhea| CHEBI:48828 )
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )
Note: Binds 2 divalent metal cations (By similarity).
Shows activity with Mn2+, Co2+ and Mg2+ but shows no activity with Zn2+ (By similarity).
Shows activity with Mn2+, Co2+ and Mg2+ but shows no activity with Zn2+ (By similarity).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 36 | a divalent metal cation 1 (UniProtKB | ChEBI) | |||
Binding site | 64 | a divalent metal cation 1 (UniProtKB | ChEBI) | |||
Binding site | 65 | a divalent metal cation 1 (UniProtKB | ChEBI) | |||
Binding site | 68 | a divalent metal cation 2 (UniProtKB | ChEBI) | |||
Binding site | 73 | a divalent metal cation 2 (UniProtKB | ChEBI) | |||
Binding site | 74 | a divalent metal cation 2 (UniProtKB | ChEBI) | |||
Binding site | 130 | a divalent metal cation 1 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 5'-deoxynucleotidase activity | |
Molecular Function | metal ion binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name5'-deoxynucleotidase HDDC2
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ1LUI2
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000311391 | 1-200 | 5'-deoxynucleotidase HDDC2 | ||
Proteomic databases
Expression
Gene expression databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length200
- Mass (Da)22,919
- Last updated2006-05-30 v1
- MD5 Checksum374157A646DFC7D7E1CAFFDA12043EC5
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX936317 EMBL· GenBank· DDBJ | CAK04454.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC095766 EMBL· GenBank· DDBJ | AAH95766.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |