Q1L8K1 · Q1L8K1_DANRE
- Proteinadenylate cyclase
- Geneadcy2b
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1139 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
Catalytic activity
- ATP = 3',5'-cyclic AMP + diphosphate
Cofactor
Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 342 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 342 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 342-347 | ATP (UniProtKB | ChEBI) | ||||
Sequence: DIVGFT | ||||||
Binding site | 343 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | ||||
Sequence: I | ||||||
Binding site | 384-386 | ATP (UniProtKB | ChEBI) | ||||
Sequence: LGD | ||||||
Binding site | 386 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 386 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 430 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 987 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 1067-1069 | ATP (UniProtKB | ChEBI) | ||||
Sequence: DIW | ||||||
Binding site | 1074-1078 | ATP (UniProtKB | ChEBI) | ||||
Sequence: NVASR | ||||||
Binding site | 1114 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | adenylate cyclase activity | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Biological Process | adenylate cyclase-activating G protein-coupled receptor signaling pathway | |
Biological Process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | |
Biological Process | cAMP biosynthetic process | |
Biological Process | intracellular signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameadenylate cyclase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ1L8K1
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 93-117 | Helical | ||||
Sequence: LIVFLLLIVMGACLALLAVFFASGL | ||||||
Transmembrane | 123-145 | Helical | ||||
Sequence: MAFIMTVPTTLAIFLAIFILVCI | ||||||
Transmembrane | 152-174 | Helical | ||||
Sequence: LLRLFSLLIWGCLVAMGYLFMFF | ||||||
Transmembrane | 180-198 | Helical | ||||
Sequence: PWDQVSFFLFIVFVVYTML | ||||||
Transmembrane | 205-227 | Helical | ||||
Sequence: AVIASVLTSSSHTLVLSICLSNT | ||||||
Transmembrane | 233-254 | Helical | ||||
Sequence: ALVWQILANIIIFICGNVAGAY | ||||||
Transmembrane | 646-666 | Helical | ||||
Sequence: YYVTCACLIFFCIFIVQVLVL | ||||||
Transmembrane | 678-699 | Helical | ||||
Sequence: MAFLLLALILCICFAGHILQWG | ||||||
Transmembrane | 720-744 | Helical | ||||
Sequence: PWIRLALTMATTALILVMAVFNMFF | ||||||
Transmembrane | 782-800 | Helical | ||||
Sequence: YFIYSCILGLISCSVFLRI | ||||||
Transmembrane | 807-827 | Helical | ||||
Sequence: IIMLGAVVAYNIIILQTHASI | ||||||
Transmembrane | 852-869 | Helical | ||||
Sequence: TMGSISLFIFFVTLLVLA |
Keywords
- Cellular component
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 18-48 | Disordered | ||||
Sequence: SHPPQLSTLTEEDEPERHKQQDEDDEEVSGV | ||||||
Compositional bias | 26-43 | Basic and acidic residues | ||||
Sequence: LTEEDEPERHKQQDEDDE | ||||||
Domain | 337-464 | Guanylate cyclase | ||||
Sequence: SILYADIVGFTRLASDCSPGELVYMLNELFGKFDQIAKDNDCMRIKILGDCYYCVSGLPDPLLDHAKNCVKMGLDMCEAIEKVREATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHME | ||||||
Domain | 935-1080 | Guanylate cyclase | ||||
Sequence: CVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNVTPGLEYAQYHDRQYMHIGTMVEFAFALVGKLDVINKHSFNDFRMRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRME |
Sequence similarities
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,139
- Mass (Da)128,976
- Last updated2007-07-10 v2
- ChecksumD2C6E6E6196D754B
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F1Q5J6 | F1Q5J6_DANRE | adcy2b | 1142 | ||
A0A8M9PB02 | A0A8M9PB02_DANRE | adcy2b | 812 | ||
A0A8M9PGG7 | A0A8M9PGG7_DANRE | adcy2b | 682 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 26-43 | Basic and acidic residues | ||||
Sequence: LTEEDEPERHKQQDEDDE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX511155 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CR759914 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |