Q1L8K1 · Q1L8K1_DANRE

Function

function

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site342Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site342Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site342-347ATP (UniProtKB | ChEBI)
Binding site343Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site384-386ATP (UniProtKB | ChEBI)
Binding site386Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site386Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site430ATP (UniProtKB | ChEBI)
Binding site987ATP (UniProtKB | ChEBI)
Binding site1067-1069ATP (UniProtKB | ChEBI)
Binding site1074-1078ATP (UniProtKB | ChEBI)
Binding site1114ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionadenylate cyclase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological ProcesscAMP biosynthetic process
Biological Processintracellular signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    adenylate cyclase
  • EC number

Gene names

    • Name
      adcy2b
    • Synonyms
      si:dkey-266i6.1

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q1L8K1
  • Secondary accessions
    • A0A8M1NDL5

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane93-117Helical
Transmembrane123-145Helical
Transmembrane152-174Helical
Transmembrane180-198Helical
Transmembrane205-227Helical
Transmembrane233-254Helical
Transmembrane646-666Helical
Transmembrane678-699Helical
Transmembrane720-744Helical
Transmembrane782-800Helical
Transmembrane807-827Helical
Transmembrane852-869Helical

Keywords

  • Cellular component

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region18-48Disordered
Compositional bias26-43Basic and acidic residues
Domain337-464Guanylate cyclase
Domain935-1080Guanylate cyclase

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,139
  • Mass (Da)
    128,976
  • Last updated
    2007-07-10 v2
  • Checksum
    D2C6E6E6196D754B
MLRAAALSLLPWRGTHLSHPPQLSTLTEEDEPERHKQQDEDDEEVSGVQQDPMFQQTAYLLEGPEDMGVSSCGLKSPDWVYESYYRMSQQHPLIVFLLLIVMGACLALLAVFFASGLDMEEHMAFIMTVPTTLAIFLAIFILVCIESVFKKLLRLFSLLIWGCLVAMGYLFMFFGGIICPWDQVSFFLFIVFVVYTMLPFSMRDAVIASVLTSSSHTLVLSICLSNTSDHMEALVWQILANIIIFICGNVAGAYHKHLMDLALKQTYHDTCNCIKSPIKLEFEKHQQERLLLSLLPAHIARVMKAEIIQRLKGPNFSQAENTNNFHNLYVQRHTNVSILYADIVGFTRLASDCSPGELVYMLNELFGKFDQIAKDNDCMRIKILGDCYYCVSGLPDPLLDHAKNCVKMGLDMCEAIEKVREATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEQGNGQSRDSYLKEHGIVTYLVINPKAEKRSPLLLSAIRPTMYGAKMRASVRMTQYLESWGAAKPFANLHHRDSMTNENGMINTRDVPLGQYNCQQRTKSQKKRFEEELNERIIRTIDGINSQKQWLKSEDIQRISLFFHNKALEKEYRATTLPAFKYYVTCACLIFFCIFIVQVLVLPKTTVLEVSFGMAFLLLALILCICFAGHILQWGKAASCTMPRLPSSSKVITNKPWIRLALTMATTALILVMAVFNMFFLGEDRMVASTSLNISNSSMDGPYGQITNSSNNKFYLPYFIYSCILGLISCSVFLRINYELKMIIMLGAVVAYNIIILQTHASILDDYSMALYKTQQPDRPGVLKDLKTMGSISLFIFFVTLLVLARQNEYYCRLDFLWRNKFKKECEEIETMENLNRVLLENVLPAHVAEHFLGRNWKNEDLYHQSYDTVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNVTPGLEYAQYHDRQYMHIGTMVEFAFALVGKLDVINKHSFNDFRMRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETNWILQTLGYMCSCRGIINVKGKGDLRTFFVHTEMTQSLSQGNVMP

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F1Q5J6F1Q5J6_DANREadcy2b1142
A0A8M9PB02A0A8M9PB02_DANREadcy2b812
A0A8M9PGG7A0A8M9PGG7_DANREadcy2b682

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias26-43Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX511155
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CR759914
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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