Q1JUZ2 · NVD_BOMMO
- ProteinCholesterol 7-desaturase nvd
- Genenvd-Bm
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids453 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes the production of 7-dehydrocholesterol (7-DHC or cholesta-5,7-dien-3beta-ol) by inserting a double bond (desaturating) at the C7-C8 single bond of cholesterol. Essential regulator of steroid biosynthesis as this reaction is the first step in the synthesis of the steroid hormone Delta7-dafachronic acid.
Catalytic activity
- cholesterol + H+ + NADPH + O2 = 7-dehydrocholesterol + 2 H2O + NADP+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 [2Fe-2S] cluster per subunit.
Pathway
Steroid hormone biosynthesis; dafachronic acid biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | 2 iron, 2 sulfur cluster binding | |
Molecular Function | cholesterol 7-desaturase (NAD(P)H) activity | |
Molecular Function | metal ion binding | |
Biological Process | cholesterol metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Chemistry
Names & Taxonomy
Protein names
- Recommended nameCholesterol 7-desaturase nvd
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Lepidoptera > Glossata > Ditrysia > Bombycoidea > Bombycidae > Bombycinae > Bombyx
Accessions
- Primary accessionQ1JUZ2
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 53-73 | Helical | ||||
Sequence: IVEYILILTLMFAFSAILYVI |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000452606 | 1-453 | Cholesterol 7-desaturase nvd | |||
Sequence: MADRQHFPSAITEAVSSNTACPDTGPKAETTNIFLLLQRNITIESSKHVFSSIVEYILILTLMFAFSAILYVIYKSYISPVFYKKELTEVGFDHIPQGPDKGRRISRAQASRRMGSKLPPPYPNGWFAVAETRELKVGSVLSIDALGQNLCVYRGEDGLARCVDAYCPHLGANLAVGGTVRGSCIECPFHKWRFNAAGTCVSLPGSDIAPKGVSIRTWCVVETDGAIWIWHDAEGREPLWEITDPPELKDFGYRGRNEFEVSAHIQEIPENGADVPHLNAVHSSSLLSDLGERYPVLHEIIGRHVWNADWTKSDDHTSLMHITQEYKVLKYDLARIDVKVTQIGPGHVRLFLKTSVGPFYIAQSVTPLGPLLQKVIHRVYSPAYNAPVGAFLVRCEAYMFERDVTIWNSKRFVSAPAYVKTDKTIRTFRNWFGQFYSEHSLSFRDALQNPLDW |
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 126-229 | Rieske | ||||
Sequence: WFAVAETRELKVGSVLSIDALGQNLCVYRGEDGLARCVDAYCPHLGANLAVGGTVRGSCIECPFHKWRFNAAGTCVSLPGSDIAPKGVSIRTWCVVETDGAIWI |
Sequence similarities
Belongs to the cholesterol 7-desaturase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length453
- Mass (Da)50,950
- Last updated2021-06-02 v2
- ChecksumADA5D4AADB19A3AF
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 140 | in Ref. 1; BAE94192 | ||||
Sequence: V → A | ||||||
Sequence conflict | 227 | in Ref. 1; BAE94192 | ||||
Sequence: I → V | ||||||
Sequence conflict | 250 | in Ref. 1; BAE94192 | ||||
Sequence: D → E | ||||||
Sequence conflict | 362 | in Ref. 1; BAE94192 | ||||
Sequence: A → V | ||||||
Sequence conflict | 442 | in Ref. 1; BAE94192 | ||||
Sequence: S → G |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB232986 EMBL· GenBank· DDBJ | BAE94192.1 EMBL· GenBank· DDBJ | mRNA | ||
BABH01021056 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |