Q1IDZ9 · Q1IDZ9_PSEE4

Function

function

DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site187[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site194[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site197[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site203[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular FunctionDNA binding
Molecular FunctionDNA N-glycosylase activity
Molecular Functionendonuclease activity
Molecular Functionmetal ion binding
Biological Processbase-excision repair, AP site formation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Endonuclease III
  • EC number
  • Alternative names
    • DNA-(apurinic or apyrimidinic site) lyase

Gene names

    • Name
      nth
    • Ordered locus names
      PSEEN1214

Organism names

Accessions

  • Primary accession
    Q1IDZ9

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain38-185HhH-GPD

Sequence similarities

Belongs to the Nth/MutY family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    212
  • Mass (Da)
    23,682
  • Last updated
    2006-06-13 v1
  • MD5 Checksum
    2D1D6A1F827BA4711ACBBAC3A701F4BC
MNAAKRLEIFRRLHEDNPDPKTELAYSTPFELLIAVILSAQATDVGVNKATARLFPVANTPQAIHALGVEGLSDYIKTIGLYNSKAKNVIETCRLLVEQHDGEVPQTREALEALPGVGRKTANVVLNTAFRQLAMAVDTHIFRVSNRTGIAPGKTVLEVEKKLLKFVPKDYLLDAHHWLILHGRYVCQARKPRCGSCRIEDLCEYKHKTSDD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CT573326
EMBL· GenBank· DDBJ
CAK14109.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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