Q1HG69 · Q1HG69_CAVPO

  • Protein
    Prostaglandin E2 receptor EP4 subtype
  • Gene
    PTGER4
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionprostaglandin E receptor activity
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
Biological Processcellular response to mechanical stimulus
Biological Processcellular response to prostaglandin E stimulus
Biological Processinflammatory response
Biological Processnegative regulation of cytokine production
Biological Processnegative regulation of eosinophil extravasation
Biological Processnegative regulation of inflammatory response
Biological Processnegative regulation of integrin activation
Biological Processpositive regulation of cytokine production
Biological Processpositive regulation of cytosolic calcium ion concentration
Biological Processpositive regulation of inflammatory response
Biological Processregulation of ossification
Biological Processregulation of stress fiber assembly
Biological Processresponse to lipopolysaccharide
Biological Processresponse to nematode
Biological ProcessT-helper cell differentiation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Prostaglandin E2 receptor EP4 subtype
  • Alternative names
    • Prostanoid EP4 receptor

Gene names

    • Name
      PTGER4

Organism names

  • Taxonomic identifier
  • Strain
    • 2N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Hystricomorpha > Caviidae > Cavia

Accessions

  • Primary accession
    Q1HG69

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane21-42Helical
Transmembrane54-77Helical
Transmembrane97-115Helical
Transmembrane135-156Helical
Transmembrane186-211Helical
Transmembrane273-296Helical

Keywords

PTM/Processing

Keywords

Expression

Gene expression databases

Interaction

Subunit

Interacts with FEM1A.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain34-331G-protein coupled receptors family 1 profile
Region357-380Disordered
Region410-487Disordered
Compositional bias421-448Polar residues
Compositional bias463-487Polar residues

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    487
  • Mass (Da)
    53,562
  • Last updated
    2006-06-13 v1
  • Checksum
    D409FDD91B8424DF
MSTAGVNTSASFTTGGLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSRRQYPDTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAVAAAAMTSACRGNTSASPAVQRFSDFRRRRSFRRIAGAEVQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVREVSRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRDRSGQHCSESRRTSSATSNHSRSFFSRELKEISSTSQTLLYLPELSENSLGGRNLLPGVPSMGQAQEETTSLRTLRVSETSDSSQGHDSETVLLVDEVSGRNRDGSAPKGSSLQVTFPSETRNLSEKCI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias421-448Polar residues
Compositional bias463-487Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAKN02031742
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
DQ489549
EMBL· GenBank· DDBJ
ABF22615.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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