Q1GA99 · RECU_LACDA

Function

function

Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.

Catalytic activity

  • Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).
    EC:3.1.21.10 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site87Mg2+ (UniProtKB | ChEBI)
Binding site89Mg2+ (UniProtKB | ChEBI)
Binding site102Mg2+ (UniProtKB | ChEBI)
Site104Transition state stabilizer
Binding site121Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionendonuclease activity
Molecular Functionmagnesium ion binding
Molecular Functionnucleic acid binding
Biological Processchromosome segregation
Biological ProcessDNA recombination
Biological ProcessDNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Holliday junction resolvase RecU
  • EC number
  • Alternative names
    • Recombination protein U homolog

Gene names

    • Name
      recU
    • Ordered locus names
      Ldb1013

Organism names

Accessions

  • Primary accession
    Q1GA99

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000167281-210Holliday junction resolvase RecU

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the RecU family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    210
  • Mass (Da)
    24,040
  • Last updated
    2006-06-27 v1
  • Checksum
    D43797AE72FCB77E
MVKYPTGSVMPLRAAQRQGKKALLKKASFSDRGMTLEQQINESNQYYLDAGIAVVHKKPTPIQIVKVDYPKRSRAVIREAYFRQASTTDYNGVYQGYYLDFEAKETRNKTSFPLKNFHEHQILHLEQCLDQEGICFALIGFMTLERYFVTPASFLIQAWQNWKAAGKSSMTLAEIEANSFEIKSGFCPALPYLEAVDRIIADRKQEHGNK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR954253
EMBL· GenBank· DDBJ
CAI97815.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help