Q1ERI2 · CITD_MONPU

Function

function

Aldehyde dehydrogenase; part of the gene cluster that mediates the biosynthesis of the mycotoxin citrinin, a hepato-nephrotoxic compound to humans due to inhibition of respiration complex III (PubMed:17586673, PubMed:19012408, PubMed:19111642, PubMed:27913218, PubMed:28238725).
The pathway begins with the synthesis of a keto-aldehyde intermediate by the citrinin PKS (pksCT) from successive condensations of 4 malonyl-CoA units, presumably with a simple acetyl-CoA starter unit (PubMed:28238725).
Release of the keto-aldehyde intermediate is consistent with the presence of the C-terminal reductive release domain (PubMed:28238725).
Mp11 collaborates with pksCT by catalyzing the hydrolysis of ACP-bound acyl intermediates to free the ACP from stalled intermediates (By similarity).
Mpl2 then catalyzes the oxidation of the C-12 methyl of the ketone intermediate to an alcohol intermediate which is further oxidized by the oxidoreductase mpl7 to produce a bisaldehyde intermediate (PubMed:27913218).
The fourth catalytic step is catalyzed by the mpl4 aldehyde dehydrogenase (PubMed:27913218).
The final transformation is the reduction of C-3 by mpl6 to provide the chemically stable citrinin nucleus (PubMed:27913218).

Catalytic activity

Pathway

Mycotoxin biosynthesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site231-236NAD+ (UniProtKB | ChEBI)
Active site253
Active site287

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aldehyde dehydrogenase mpl4
  • EC number
  • Alternative names
    • Citrinin synthesis protein mpl4

Gene names

    • Name
      mpl4
    • Synonyms
      orf1

Organism names

Accessions

  • Primary accession
    Q1ERI2

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004403201-501Aldehyde dehydrogenase mpl4

Structure

Family & Domains

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    501
  • Mass (Da)
    54,135
  • Last updated
    2006-07-11 v1
  • Checksum
    294E2D92F88C25F0
MAEAAARILEALPAVCEYRWSCKDASKRFTVVNPATGEPITVVQAGNLDTVQGAIQASHRAFESWRWKTRQERSLYLLQAADELQKHSHELAVLLCLENGKPVKDASFDVGFLVQVFRYFGSIVDKLPSEFFDQGSIYSSVIYEPHGVCVGILPFNWPPVHAGGKLAPCLAAGNTMVLKPGEQAPLTLMRIVEILQSVFPADVVQAVPGLGPEIPQALINHPLVKMVSLTGSTASGSQAAQTAAVTLTPTVLELGGKNAFVVFEDADLELVVRDAIDGAFFNKGESCTAASRILVHKDLYPTLVSRLTAAVKKLRTGDGLDETTHIGPVVSRERQQEVLSYIEQGKREGATLAAQGDPPTAGRLSGGFFVPPTLFTDVTADMTIAQREIFGPVVTVGSFETEEEAVKTVNSSQYGLFAGVYSSDFTRAMRVTRKLDVGVVLVNNYFRALLGTPFGGVKDSGYGREHWIGTLREWSRVKNVRFPSGLSPIPAWGGAVDVCKL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB243687
EMBL· GenBank· DDBJ
BAE95336.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp