Q1ERH9 · CITA_MONPU

Function

function

Esterase; part of the gene cluster that mediates the biosynthesis of the mycotoxin citrinin, a hepato-nephrotoxic compound to humans due to inhibition of respiration complex III (PubMed:17586673, PubMed:19012408, PubMed:19111642, PubMed:27913218, PubMed:28238725).
The pathway begins with the synthesis of a keto-aldehyde intermediate by the citrinin PKS (pksCT) from successive condensations of 4 malonyl-CoA units, presumably with a simple acetyl-CoA starter unit (PubMed:28238725).
Release of the keto-aldehyde intermediate is consistent with the presence of the C-terminal reductive release domain (PubMed:28238725).
Mp11 collaborates with pksCT by catalyzing the hydrolysis of ACP-bound acyl intermediates to free the ACP from stalled intermediates (By similarity).
Mpl2 then catalyzes the oxidation of the C-12 methyl of the ketone intermediate to an alcohol intermediate which is further oxidized by the oxidoreductase mpl7 to produce a bisaldehyde intermediate (PubMed:27913218).
The fourth catalytic step is catalyzed by the mpl4 aldehyde dehydrogenase (PubMed:27913218).
The final transformation is the reduction of C-3 by mpl6 to provide the chemically stable citrinin nucleus (PubMed:27913218).

Pathway

Mycotoxin biosynthesis.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site174Charge relay system
Active site259Charge relay system
Active site287Charge relay system

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionhydrolase activity
Biological Processsecondary metabolite biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Esterase mpl1
  • EC number
  • Alternative names
    • Citrinin synthesis protein B

Gene names

    • Name
      mpl1
    • Synonyms
      ctnB

Organism names

Accessions

  • Primary accession
    Q1ERH9

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004403141-313Esterase mpl1

Structure

Family & Domains

Sequence similarities

Belongs to the LovG family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    313
  • Mass (Da)
    35,226
  • Last updated
    2006-07-11 v1
  • Checksum
    561F532C91DFFD49
MKGQTGLRSLALLYISPLYILERLPLKLSAPDTLVVRGSFIVPTEPLYPSITMVQTNLEVVDDTLHLPRILCLHGGGSNAAIFQAQCRRLIAQLRSEFRFVFAQAPFLSDAEPNVMSVYSQWGPFRRWLRWCPDHPEIRPEDAIRAIDDCLEDVKRQDDAKGATGAWVGLLGFSQGAKMCASLLYRQQIRQELRGRSFAGSDYRFGVLLAGRAPLVSLDPDLDLNSSLPDVSQITDAKYHGPSQDVLRIPTVHVHGMRDPHVDLHRQLFEEFCAPESRRLVEWDGDHRVPLKYNDVSLVAYQIRELATQTGAP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB243687
EMBL· GenBank· DDBJ
BAE95339.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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