Q1E6K9 · KU80_COCIM

Function

function

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromosome, telomeric region
Cellular ComponentKu70:Ku80 complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functiondamaged DNA binding
Molecular Functiondouble-stranded DNA binding
Molecular Functionhelicase activity
Molecular Functiontelomeric DNA binding
Biological ProcessDNA recombination
Biological Processdouble-strand break repair via nonhomologous end joining
Biological Processtelomere maintenance

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent DNA helicase II subunit 2
  • EC number
  • Alternative names
    • ATP-dependent DNA helicase II subunit Ku80

Gene names

    • Name
      KU80
    • ORF names
      CIMG_01804

Organism names

Accessions

  • Primary accession
    Q1E6K9
  • Secondary accessions
    • J3KKC6

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002783521-731ATP-dependent DNA helicase II subunit 2

Interaction

Subunit

Heterodimer of Ku70 and Ku80.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain238-486Ku

Sequence similarities

Belongs to the ku80 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    731
  • Mass (Da)
    82,008
  • Last updated
    2006-07-11 v1
  • Checksum
    E580014E490FBEE8
MAEKEATVYIVDVGHSMGKCRGGRTISDLDWMMLYVWDRITTTVSTGRKTATVGVVGLRTDGSSNPLWEKDEEESYAHLSVFQEIGQMLMPDIRKLRDLVKPSNTNQGDAISSIILAIDMIVRYCKRLKYKRKIVLVTDGRSTMDSDGIDSIVSKIKEEGIELVILGVDFDDPDYGFKEEDKDPFKTKNESVLKILADDADGAYGTLAQAVEEMTTPRIKVVRGIPSFRGDLRLGDPSQYSTGLTIQVERYYRTYVARPPAASAFALSIAPPKGQSTAESSVTLQNGDSTVETANASNNLSGVRNARSYQVIDENAPGGKKEVERDDLAKGYEYGRTAVHISESDEVITKLDTTAALEFIGFIQSENYERYMNMSTSNVIIAQKINDKAILALSSMIHALFELEYYAIGRLVTKDGKPPLMVLLAPLIETDFECLLEVQLPFAEDTRSYRFPPLDKIVTVSGKVVKEHRNLPSDDLLETMGKYVEDMDLSEFDENGDPFQSLALEDCYSPLVHRIDQAIRWRAVHPTKPLPPVPKVLEKLSHWPEELVKKSHDSLRDLISISAVKKVPPKAKGRKRRREADKPLSGLNVDDLLRGEKRLKISPENPIPEFKQTLANTEDISAISDAVKQMSAIIEDQIRQSLGDINYDRAIEGIGTMREELIAYEEPGLYNDFIRGLKEKLLDDKLGGDRREMWWLIRKSRLGLIDQKALDISDITEEQAREFLSSRPTTV

Sequence caution

The sequence EAS36450.3 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GG704911
EMBL· GenBank· DDBJ
EAS36450.3
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

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