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Q1DAS7 · Q1DAS7_MYXXD

Function

function

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.

Catalytic activity

  • Hydrolysis of proteins in presence of ATP.
    EC:3.4.21.53 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site, active site.

1817100200300400500600700800
Type
IDPosition(s)Description
Binding site368-375ATP (UniProtKB | ChEBI)
Active site691
Active site734

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionsequence-specific DNA binding
Molecular Functionserine-type endopeptidase activity
Biological Processcellular response to heat
Biological Processprotein quality control for misfolded or incompletely synthesized proteins

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Lon protease
  • EC number
  • Alternative names
    • ATP-dependent protease La

Gene names

    • Name
      lon
    • Ordered locus names
      MXAN_2017

Organism names

Accessions

  • Primary accession
    Q1DAS7

Proteomes

Subcellular Location

Keywords

Expression

Induction

By heat shock.

Interaction

Subunit

Homohexamer. Organized in a ring with a central cavity.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, coiled coil, region.

Type
IDPosition(s)Description
Domain18-216Lon N-terminal
Coiled coil202-276
Domain604-785Lon proteolytic
Region789-817Disordered

Sequence similarities

Belongs to the peptidase S16 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    817
  • Mass (Da)
    91,815
  • Last updated
    2006-07-11 v1
  • MD5 Checksum
    1AC1F33CC1B9CBE5619B91460FB764E1
MFFGRDDKKEAQKRGLTVPLLPLRDIIVFPHMVVPLFVGREKSIAALKDAMAHKGPDDKAVILLAAQKKAKTNDPTPDDIFHFGTLGHVIQLLPLPDGTVKVLVEGVRRAKVKKFHPNDAFFMVEVEEVEEQTEKTVELEALVRSVHSVFEAFVKLNKRIPPEMLMQVASIDDPARLADTIVAHLSLKLNDKQALLETESPAKRLEKLYELMQGEIEILQVEKKIRTRVKKQMEKTQKEYYLNEQMQAIQKELGERDEFKNEIQEIEEKLKNKRMSKEATLKVKKELKKLRMMSPMSAEATVVRNYIDWIISLPWYDETQDRLDVTEAETVLNEDHYGLKKPKERILEYLAVQQLVKKLKGPVLCFVGPPGVGKTSLARSIARATGRKFVRLSLGGVRDEAEIRGHRRTYIGAMPGKLIQSLKKAGSNNPVFLLDEIDKMSTDFRGDPSAALLEVLDPEQNHTFNDHYLDLDYDLSKVMFICTANTMHNIPGPLQDRMEVIRIAGYTEPEKLSIARRYLIPKEQEANGLSDLKVDISDPALRTIIHRYTRESGVRSLEREIGGVFRKIARDVLKNGKRDIDVDRKMAMKFLGTPRYRYGMAEAEDQVGIVTGLAWTELGGEILTTEATIMPGKGKLIITGKLGEVMQESAQAAMSYVRSRAERFGIDRKVFENYDIHVHLPEGAIPKDGPSAGVTICTALVSALTRVLIRRDVAMTGEITLRGRVLPIGGLKEKTLAAHRAGIKTVLIPKANKKDLKDIPLKIRKQLRIVPVEFVDDVLREALVLEKPEEFGRKPTTDGGKLGGTTELPASPAVAPA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000113
EMBL· GenBank· DDBJ
ABF92993.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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