Q1CT37 · SPEE_HELPH

Function

function

Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.

Catalytic activity

Pathway

Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.

Features

Showing features for binding site, active site.

126220406080100120140160180200220240260
TypeIDPosition(s)Description
Binding site29S-methyl-5'-thioadenosine (UniProtKB | ChEBI)
Binding site83spermidine (UniProtKB | ChEBI)
Active site155Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionspermidine synthase activity
Biological Processspermidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Polyamine aminopropyltransferase
  • Alternative names
    • Putrescine aminopropyltransferase
      (PAPT
      )
    • Spermidine synthase
      (SPDS
      ; SPDSY
      ) (EC:2.5.1.16
      ) . EC:2.5.1.16 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      speE
    • Ordered locus names
      HPAG1_0818

Organism names

Accessions

  • Primary accession
    Q1CT37

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000120021-262Polyamine aminopropyltransferase

Interaction

Subunit

Homodimer or homotetramer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-249PABS

Sequence similarities

Belongs to the spermidine/spermine synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    262
  • Mass (Da)
    30,474
  • Last updated
    2006-07-11 v1
  • Checksum
    AC2C2A2D407A112B
MWITQEITPYLRKEYTIEAKLLDVRSEHNILEIFKSKDFGEIAMLNCQLLFKNFLHIESELLAHMGGCTKKELKEVLIVDGFDLELAHQLFKYDTHIDFVQADEKILDSFISFFPHFHEVKNNKNFTHAKQLLDLDIKKYDLILCLQEPDIHKMDGLKRMLKEDGVFISVAKHPLLEHVSMQNALKNMGGVFSVAMPFVAPLRILSNKGYIYASFKTHPLKDLMTPKIEALTSMRYYNEDIHRAAFALPKNLQEVFKDNIKS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000241
EMBL· GenBank· DDBJ
ABF84885.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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