Q1ACB3 · HSTC_ARATH
- ProteinHomogentisate solanesyltransferase, chloroplastic
- GeneHST
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids386 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Involved in the synthesis of plastoquinone-9. Can use both homogentisic acid and 2,5-dihydroxyphenylacetic acid gamma-lactone as prenyl acceptors, and solanesyl diphosphate > farnesyl diphosphate > geranylgeranyl diphosphate >> phytyl diphosphate as prenyl donors. Do not catalyze the decardoxylation of homogentisate uncoupled from prenylation.
Miscellaneous
Seeds overexpressing HST accumulate increased levels of tocopherol.
Catalytic activity
- all-trans-nonaprenyl diphosphate + homogentisate + H+ = 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate
Activity regulation
Inhibited by haloxydine (3,5-dichloro-2,6-difluoro-4-haloxypyridine).
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chloroplast membrane | |
Molecular Function | homogentisate solanesyltransferase activity |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHomogentisate solanesyltransferase, chloroplastic
- EC number
- Short namesAtHST
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ1ACB3
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Plastid, chloroplast membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 130-150 | Helical | ||||
Sequence: VLKALSGLLALICGNGYIVGI | ||||||
Transmembrane | 181-201 | Helical | ||||
Sequence: LVIFFAIAGLLVVGFNFGPFI | ||||||
Transmembrane | 204-220 | Helical | ||||
Sequence: LYSLGLFLGTIYSVPPL | ||||||
Transmembrane | 225-245 | Helical | ||||
Sequence: FPVAAFLIIATVRGFLLNFGV | ||||||
Transmembrane | 259-279 | Helical | ||||
Sequence: WSAPVAFITSFVTLFALVIAI | ||||||
Transmembrane | 306-326 | Helical | ||||
Sequence: IAFLGSGLLLVNYVSAISLAF | ||||||
Transmembrane | 335-355 | Helical | ||||
Sequence: SLMIPAHVILASGLIFQTWVL | ||||||
Transmembrane | 365-385 | Helical | ||||
Sequence: ISGYYRFIWNLFYAEYLLFPF |
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 148-149 | In pds2; albino phenotype. | ||||
Sequence: Missing |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 19 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for transit peptide, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transit peptide | 1-69 | Chloroplast | ||||
Sequence: MELSISQSPRVRFSSLAPRFLAASHHHRPSVHLAGKFISLPRDVRFTSLSTSRMRSKFVSTNYRKISIR | ||||||
Chain | PRO_0000409869 | 70-386 | Homogentisate solanesyltransferase, chloroplastic | |||
Sequence: ACSQVGAAESDDPVLDRIARFQNACWRFLRPHTIRGTALGSTALVTRALIENTHLIKWSLVLKALSGLLALICGNGYIVGINQIYDIGIDKVNKPYLPIAAGDLSVQSAWLLVIFFAIAGLLVVGFNFGPFITSLYSLGLFLGTIYSVPPLRMKRFPVAAFLIIATVRGFLLNFGVYHATRAALGLPFQWSAPVAFITSFVTLFALVIAITKDLPDVEGDRKFQISTLATKLGVRNIAFLGSGLLLVNYVSAISLAFYMPQVFRGSLMIPAHVILASGLIFQTWVLEKANYTKEAISGYYRFIWNLFYAEYLLFPFL |
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced. According to EST sequences.
Q1ACB3-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length386
- Mass (Da)42,841
- Last updated2006-07-11 v1
- Checksum54D13052FE67F277
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F4J8K0 | F4J8K0_ARATH | HST | 393 |
Sequence caution
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQ231060 EMBL· GenBank· DDBJ | ABB70127.1 EMBL· GenBank· DDBJ | mRNA | ||
AP002040 EMBL· GenBank· DDBJ | BAB03104.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002686 EMBL· GenBank· DDBJ | AEE75125.1 EMBL· GenBank· DDBJ | Genomic DNA |