Q1ACB3 · HSTC_ARATH

Function

function

Involved in the synthesis of plastoquinone-9. Can use both homogentisic acid and 2,5-dihydroxyphenylacetic acid gamma-lactone as prenyl acceptors, and solanesyl diphosphate > farnesyl diphosphate > geranylgeranyl diphosphate >> phytyl diphosphate as prenyl donors. Do not catalyze the decardoxylation of homogentisate uncoupled from prenylation.

Miscellaneous

Seeds overexpressing HST accumulate increased levels of tocopherol.

Caution

Was initially thought to have a homogentisate phytyltransferase activity and to be involved in tocopherol biosynthesis.

Catalytic activity

Activity regulation

Inhibited by haloxydine (3,5-dichloro-2,6-difluoro-4-haloxypyridine).

GO annotations

AspectTerm
Cellular Componentchloroplast membrane
Molecular Functionhomogentisate solanesyltransferase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Homogentisate solanesyltransferase, chloroplastic
  • EC number
  • Short names
    AtHST
  • Alternative names
    • Homogentisate phytyltransferase 2 (AtHPT2)
    • Vitamin E pathway gene 2-2 protein (AtVTE2-2)

Gene names

    • Name
      HST
    • Synonyms
      HPT2, VTE2-2
    • ORF names
      MEC18
    • Ordered locus names
      At3g11945

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q1ACB3
  • Secondary accessions
    • Q9LHM7

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Plastid, chloroplast membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane130-150Helical
Transmembrane181-201Helical
Transmembrane204-220Helical
Transmembrane225-245Helical
Transmembrane259-279Helical
Transmembrane306-326Helical
Transmembrane335-355Helical
Transmembrane365-385Helical

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis148-149In pds2; albino phenotype.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 19 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for transit peptide, chain.

TypeIDPosition(s)Description
Transit peptide1-69Chloroplast
ChainPRO_000040986970-386Homogentisate solanesyltransferase, chloroplastic

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the UbiA prenyltransferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced. According to EST sequences.

Q1ACB3-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    386
  • Mass (Da)
    42,841
  • Last updated
    2006-07-11 v1
  • Checksum
    54D13052FE67F277
MELSISQSPRVRFSSLAPRFLAASHHHRPSVHLAGKFISLPRDVRFTSLSTSRMRSKFVSTNYRKISIRACSQVGAAESDDPVLDRIARFQNACWRFLRPHTIRGTALGSTALVTRALIENTHLIKWSLVLKALSGLLALICGNGYIVGINQIYDIGIDKVNKPYLPIAAGDLSVQSAWLLVIFFAIAGLLVVGFNFGPFITSLYSLGLFLGTIYSVPPLRMKRFPVAAFLIIATVRGFLLNFGVYHATRAALGLPFQWSAPVAFITSFVTLFALVIAITKDLPDVEGDRKFQISTLATKLGVRNIAFLGSGLLLVNYVSAISLAFYMPQVFRGSLMIPAHVILASGLIFQTWVLEKANYTKEAISGYYRFIWNLFYAEYLLFPFL

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
F4J8K0F4J8K0_ARATHHST393

Sequence caution

The sequence BAB03104.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ231060
EMBL· GenBank· DDBJ
ABB70127.1
EMBL· GenBank· DDBJ
mRNA
AP002040
EMBL· GenBank· DDBJ
BAB03104.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002686
EMBL· GenBank· DDBJ
AEE75125.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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