Q19969 · IMA3_CAEEL

  • Protein
    Importin subunit alpha-3
  • Gene
    ima-3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:11311162).
Promotes docking of import substrates to the nuclear envelope (PubMed:11311162).
Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (PubMed:11311162).
Necessary for correct nucleoporin localization within the germline (PubMed:11311162).
Essential gene for embryonic and larval development (PubMed:11311162).
May be dispensable for axon development, but required for axon regeneration in both mechanosensory and motor neurons (PubMed:31417366).
Required for oogenic development, ima-1 and ima-2 cannot functionally compensate for loss of ima-3 (PubMed:11311162).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnuclear envelope
Cellular Componentnuclear pore
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor binding
Molecular Functionnuclear import signal receptor activity
Molecular Functionnuclear localization sequence binding
Biological Processembryo development ending in birth or egg hatching
Biological Processfemale gamete generation
Biological Processgamete generation
Biological Processmeiosis I
Biological Processnematode larval development
Biological ProcessNLS-bearing protein import into nucleus
Biological Processnuclear pore organization
Biological Processoogenesis
Biological Processpositive regulation of axon extension involved in regeneration
Biological Processprotein import into nucleus
Biological Processreproductive process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Importin subunit alpha-3
  • Alternative names
    • Karyopherin subunit alpha-3

Gene names

    • Name
      ima-3
    • ORF names
      F32E10.4

Organism names

  • Taxonomic identifier
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q19969
  • Secondary accessions
    • O44925

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Larval lethality (PubMed:31417366).
Mechanosensory neurons are born and develop normally (PubMed:31417366).
However, cre-mediated knockdown targeted to mechanosensory neurons severely impairs axon regrowth of mechanosensory PLM neurons after injury (PubMed:31417366).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001207361-514Importin subunit alpha-3

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in larval and adult germline and somatic tissues, including neurons.

Developmental stage

Expressed at high levels throughout all developmental stages.

Gene expression databases

    • WBGene00002074Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues

Interaction

Subunit

Forms a complex with an importin beta subunit (PubMed:11311162).
May interact with transcription factor cebp-1 (via N-terminus) (PubMed:31417366).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias, repeat.

Type
IDPosition(s)Description
Domain1-51IBB
Region1-62Disordered
Compositional bias14-48Basic and acidic residues
Repeat101-142ARM 1
Repeat143-187ARM 2
Repeat188-226ARM 3
Repeat227-271ARM 4
Repeat272-311ARM 5
Repeat312-353ARM 6
Repeat354-393ARM 7
Repeat394-436ARM 8
Region485-514Disordered

Sequence similarities

Belongs to the importin alpha family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    514
  • Mass (Da)
    56,163
  • Last updated
    2000-12-01 v2
  • Checksum
    76F6DE2350E9BE89
MSSNRQAYYKNNAKEQIGKEKRNEEVVSIRKDKREEAISKRRNINTQIEDDSETSTTPPGPFDANLLRLTVAAAQSSDPAEQLTAVQQARKMLSTDRNPPIDDLIGSGILPVLVQCLSSTDPNLQFEAAWALTNIASGTSEQTQAVVNAGAVPLFLQLLSCGNLNVCEQSVWALGNIIGDGPHFRDYCLELGILQPLLQFINPEIPIGFLRNVTWVIVNLCRCKDPAPSPAVVRTILPALSLLIHHQDTNILIDTVWALSYLTDGGNEHIQMVIEAQVVTHLVPLLGHVDVKVQTAALRAVGNIVTGTDEQTQLVLDSGVLRFMPGLLAHYKEKINKEAVWFVSNITAGNQQQVQDVFDAGIMPMIIHLLDRGDFPTQKEAAWAISNVTISGRPNQVEQMVKLGVLRPFCAMLSCTDSQIIQVVLDGINNILKMAGEAAEQVTSEIEECGGLDKIENLQNHENEDIYKLAFEIIDNFFSSDDETGNVEGAQSSAFGGDVPPVPDAPNGGWNFGK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias14-48Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF040995
EMBL· GenBank· DDBJ
AAB97171.1
EMBL· GenBank· DDBJ
mRNA
FO081278
EMBL· GenBank· DDBJ
CCD70435.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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