Q19969 · IMA3_CAEEL
- ProteinImportin subunit alpha-3
- Geneima-3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids514 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:11311162).
Promotes docking of import substrates to the nuclear envelope (PubMed:11311162).
Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (PubMed:11311162).
Necessary for correct nucleoporin localization within the germline (PubMed:11311162).
Essential gene for embryonic and larval development (PubMed:11311162).
May be dispensable for axon development, but required for axon regeneration in both mechanosensory and motor neurons (PubMed:31417366).
Required for oogenic development, ima-1 and ima-2 cannot functionally compensate for loss of ima-3 (PubMed:11311162).
Promotes docking of import substrates to the nuclear envelope (PubMed:11311162).
Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (PubMed:11311162).
Necessary for correct nucleoporin localization within the germline (PubMed:11311162).
Essential gene for embryonic and larval development (PubMed:11311162).
May be dispensable for axon development, but required for axon regeneration in both mechanosensory and motor neurons (PubMed:31417366).
Required for oogenic development, ima-1 and ima-2 cannot functionally compensate for loss of ima-3 (PubMed:11311162).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nuclear envelope | |
Cellular Component | nuclear pore | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor binding | |
Molecular Function | nuclear import signal receptor activity | |
Molecular Function | nuclear localization sequence binding | |
Biological Process | embryo development ending in birth or egg hatching | |
Biological Process | female gamete generation | |
Biological Process | gamete generation | |
Biological Process | meiosis I | |
Biological Process | nematode larval development | |
Biological Process | NLS-bearing protein import into nucleus | |
Biological Process | nuclear pore organization | |
Biological Process | oogenesis | |
Biological Process | positive regulation of axon extension involved in regeneration | |
Biological Process | protein import into nucleus | |
Biological Process | reproductive process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameImportin subunit alpha-3
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ19969
- Secondary accessions
Proteomes
Organism-specific databases
Phenotypes & Variants
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000120736 | 1-514 | Importin subunit alpha-3 | ||
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in larval and adult germline and somatic tissues, including neurons.
Developmental stage
Expressed at high levels throughout all developmental stages.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, repeat.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1-51 | IBB | |||
Region | 1-62 | Disordered | |||
Compositional bias | 14-48 | Basic and acidic residues | |||
Repeat | 101-142 | ARM 1 | |||
Repeat | 143-187 | ARM 2 | |||
Repeat | 188-226 | ARM 3 | |||
Repeat | 227-271 | ARM 4 | |||
Repeat | 272-311 | ARM 5 | |||
Repeat | 312-353 | ARM 6 | |||
Repeat | 354-393 | ARM 7 | |||
Repeat | 394-436 | ARM 8 | |||
Region | 485-514 | Disordered | |||
Sequence similarities
Belongs to the importin alpha family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length514
- Mass (Da)56,163
- Last updated2000-12-01 v2
- Checksum76F6DE2350E9BE89
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 14-48 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF040995 EMBL· GenBank· DDBJ | AAB97171.1 EMBL· GenBank· DDBJ | mRNA | ||
FO081278 EMBL· GenBank· DDBJ | CCD70435.1 EMBL· GenBank· DDBJ | Genomic DNA |