Q19546 · WRN_CAEEL
- ProteinATP-dependent helicase wrn-1
- Genewrn-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1056 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent 3'-5' DNA-helicase activity. May be involved in the control of genomic stability (By similarity).
Miscellaneous
Unlike orthologs in vertebrates, this protein does not have an exonuclease domain.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Cofactor
Note: Binds a Zn2+ ion per subunit.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | cytoplasm | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Cellular Component | site of double-strand break | |
Molecular Function | 3'-5' DNA helicase activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | DNA binding | |
Molecular Function | four-way junction helicase activity | |
Molecular Function | isomerase activity | |
Molecular Function | metal ion binding | |
Biological Process | determination of adult lifespan | |
Biological Process | DNA metabolic process | |
Biological Process | DNA unwinding involved in DNA replication | |
Biological Process | double-strand break repair via homologous recombination | |
Biological Process | G-quadruplex DNA unwinding | |
Biological Process | response to ionizing radiation | |
Biological Process | telomere maintenance |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent helicase wrn-1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ19546
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000205048 | 1-1056 | ATP-dependent helicase wrn-1 | |||
Sequence: MISDDDDLPSTRPGSVNEELPETEPEDNDELPETEPESDSDKPTVTSNKTENQVADEDYDSFDDFVPSQTHTASKIPVKNKRAKKCTVESDSSSSDDSDQGDDCEFIPACDETQEVPKIKRGYTLRTRASVKNKCDDSWDDGIDEEDVSKRSEDTLNDSFVDPEFMDSVLDNQLTIKGKKQFLDDGEFFTDRNVPQIDEATKMKWASMTSPPQEALNALNEFFGHKGFREKQWDVVRNVLGGKDQFVLMSTGYGKSVCYQLPSLLLNSMTVVVSPLISLMNDQVTTLVSKGIDAVKLDGHSTQIEWDQVANNMHRIRFIYMSPEMVTSQKGLELLTSCRKHISLLAIDEAHCVSQWGHDFRNSYRHLAEIRNRSDLCNIPMIALTATATVRVRDDVIANLRLRKPLITTTSFDRKNLYISVHSSKDMAEDLGLFMKTDEVKGRHFGGPTIIYCQTKQMVDDVNCVLRRIGVRSAHYHAGLTKNQREKAHTDFMRDKITTIVATVAFGMGIDKPDVRNVIHYGCPNNIESYYQEIGRAGRDGSPSICRVFWAPKDLNTIKFKLRNSQQKEEVVENLTMMLRQLELVLTTVGCRRYQLLKHFDPSYAKPPTMQADCCDRCTEMLNGNQDSSSSIVDVTTESKWLFQVINEMYNGKTGIGKPIEFLRGSSKEDWRIKTTSQQKLFGIGKHIPDKWWKALAASLRIAGYLGEVRLMQMKFGSCITLSELGERWLLTGKEMKIDATPILLQGKKEKAAPSTVPGASRSQSTKSSTEIPTKILGANKIREYEPANENEQLMNLKKQEVTGLPEKIDQLRSRLDDIRVGIANMHEVAPFQIVSNTVLDCFANLRPTSASNLEMIDGMSAQQKSRYGKRFVDCVVQFSKETGIATNVNANDMIPPELISKMQKVLSDAVRRVYTEHLISRSTAKEVATARGISEGTVYSYLAMAVEKGLPLHLDKLNVSRKNIAMALNAVRVHLGSNVAVLTPWVEAMGVVPDFNQLKLIRAILIYEYGLDTSENQEKPDIQSMPSTSNPSTIKTVPSTPSSSLRAPPLKKFKL |
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, repeat, compositional bias, domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-102 | Disordered | ||||
Sequence: MISDDDDLPSTRPGSVNEELPETEPEDNDELPETEPESDSDKPTVTSNKTENQVADEDYDSFDDFVPSQTHTASKIPVKNKRAKKCTVESDSSSSDDSDQGD | ||||||
Repeat | 17-26 | 1 | ||||
Sequence: NEELPETEPE | ||||||
Region | 17-37 | 2 X 10 AA repeats of N-[ED]-E-L-P-E-T-E-P-E | ||||
Sequence: NEELPETEPEDNDELPETEPE | ||||||
Compositional bias | 20-36 | Acidic residues | ||||
Sequence: LPETEPEDNDELPETEP | ||||||
Repeat | 28-37 | 2 | ||||
Sequence: NDELPETEPE | ||||||
Domain | 236-406 | Helicase ATP-binding | ||||
Sequence: VRNVLGGKDQFVLMSTGYGKSVCYQLPSLLLNSMTVVVSPLISLMNDQVTTLVSKGIDAVKLDGHSTQIEWDQVANNMHRIRFIYMSPEMVTSQKGLELLTSCRKHISLLAIDEAHCVSQWGHDFRNSYRHLAEIRNRSDLCNIPMIALTATATVRVRDDVIANLRLRKPL | ||||||
Motif | 348-351 | DEAH box | ||||
Sequence: DEAH | ||||||
Domain | 427-583 | Helicase C-terminal | ||||
Sequence: MAEDLGLFMKTDEVKGRHFGGPTIIYCQTKQMVDDVNCVLRRIGVRSAHYHAGLTKNQREKAHTDFMRDKITTIVATVAFGMGIDKPDVRNVIHYGCPNNIESYYQEIGRAGRDGSPSICRVFWAPKDLNTIKFKLRNSQQKEEVVENLTMMLRQLE | ||||||
Region | 749-771 | Disordered | ||||
Sequence: KEKAAPSTVPGASRSQSTKSSTE | ||||||
Compositional bias | 757-771 | Polar residues | ||||
Sequence: VPGASRSQSTKSSTE | ||||||
Domain | 806-886 | HRDC | ||||
Sequence: PEKIDQLRSRLDDIRVGIANMHEVAPFQIVSNTVLDCFANLRPTSASNLEMIDGMSAQQKSRYGKRFVDCVVQFSKETGIA | ||||||
Compositional bias | 1018-1047 | Polar residues | ||||
Sequence: QEKPDIQSMPSTSNPSTIKTVPSTPSSSLR | ||||||
Region | 1018-1056 | Disordered | ||||
Sequence: QEKPDIQSMPSTSNPSTIKTVPSTPSSSLRAPPLKKFKL |
Sequence similarities
Belongs to the helicase family. RecQ subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,056
- Mass (Da)118,523
- Last updated2001-10-01 v2
- Checksum99C23E70D06DAA0B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 20-36 | Acidic residues | ||||
Sequence: LPETEPEDNDELPETEP | ||||||
Compositional bias | 757-771 | Polar residues | ||||
Sequence: VPGASRSQSTKSSTE | ||||||
Compositional bias | 1018-1047 | Polar residues | ||||
Sequence: QEKPDIQSMPSTSNPSTIKTVPSTPSSSLR |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FO080970 EMBL· GenBank· DDBJ | CCD68193.1 EMBL· GenBank· DDBJ | Genomic DNA |