Q18885 · BTF3_CAEEL
- ProteinTranscription factor BTF3 homolog
- Geneicd-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids161 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May be a general transcription factor that can form a stable complex with RNA polymerase II (By similarity).
May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER) (By similarity).
In response to heat stress, plays a role in modulating the unfolded protein response by negatively regulating the accumulation of proteins such as the chaperone protein hsp-4 in the endoplasmic reticulum (PubMed:22957041).
Required to suppress apoptosis in neuronal and intestinal cells to promote development (PubMed:12944970).
May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER) (By similarity).
In response to heat stress, plays a role in modulating the unfolded protein response by negatively regulating the accumulation of proteins such as the chaperone protein hsp-4 in the endoplasmic reticulum (PubMed:22957041).
Required to suppress apoptosis in neuronal and intestinal cells to promote development (PubMed:12944970).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | mitochondrion | |
Cellular Component | nascent polypeptide-associated complex | |
Cellular Component | nucleus | |
Biological Process | embryo development ending in birth or egg hatching | |
Biological Process | negative regulation of apoptotic process | |
Biological Process | negative regulation of protein localization to endoplasmic reticulum | |
Biological Process | regulation of cellular response to heat |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTranscription factor BTF3 homolog
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ18885
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
RNAi-mediated knockdown mostly results in embryonic lethality, but embryos that do hatch produce larvae with a large number of apoptotic cell corpses, which are first present at the comma stage of development (PubMed:12944970).
Surviving animals are uncoordinated (PubMed:12944970).
RNAi-mediated knockdown results in increased neuronal and intestinal cell death and a reduced number of male tail rays in larvae (PubMed:12944970).
RNAi-mediated knockdown in larvae results in increased survival and mobility in response to a constant temperature of 36 degrees Celsius, when compared to wild-type (PubMed:22957041).
RNAi-mediated knockdown in adults results in embryos with severe morphological defects and high numbers of enlarged bi-refringent lipofuscin glo-1-positive granules in their gut cells, and increased cell death and degeneration (PubMed:22957041).
These embryos also have increased expression of the endoplasmic reticulum-specific chaperone protein hsp-4 in regions of the embryo that contain gut and epithelial cells (PubMed:22957041).
Surviving animals are uncoordinated (PubMed:12944970).
RNAi-mediated knockdown results in increased neuronal and intestinal cell death and a reduced number of male tail rays in larvae (PubMed:12944970).
RNAi-mediated knockdown in larvae results in increased survival and mobility in response to a constant temperature of 36 degrees Celsius, when compared to wild-type (PubMed:22957041).
RNAi-mediated knockdown in adults results in embryos with severe morphological defects and high numbers of enlarged bi-refringent lipofuscin glo-1-positive granules in their gut cells, and increased cell death and degeneration (PubMed:22957041).
These embryos also have increased expression of the endoplasmic reticulum-specific chaperone protein hsp-4 in regions of the embryo that contain gut and epithelial cells (PubMed:22957041).
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000213550 | 1-161 | Transcription factor BTF3 homolog | |||
Sequence: MDSKAIAERIKKLQAQQEHVRIGGKGTPRRKKKVIHKTAAADDKKLQSNLKKLSVTNIPGIEEVNMIKDDGTVIHFNNPKVQTSVPANTFSVTGSADNKQITEMLPGILNQLGPESLTHLKKLANNVTKLGPDGKGEDEDVPELVGDFDAASKNETKADEQ |
Proteomic databases
PTM databases
Expression
Interaction
Subunit
May be part of the nascent polypeptide-associated complex (NAC), which is a heterodimer of icd-2 and icd-1 (via NAC-A/B domains).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q18885 | icd-2 Q86S66 | 6 | EBI-326530, EBI-326549 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 16-41 | Disordered | ||||
Sequence: QQEHVRIGGKGTPRRKKKVIHKTAAA | ||||||
Domain | 40-105 | NAC-A/B | ||||
Sequence: AADDKKLQSNLKKLSVTNIPGIEEVNMIKDDGTVIHFNNPKVQTSVPANTFSVTGSADNKQITEML | ||||||
Region | 128-161 | Disordered | ||||
Sequence: TKLGPDGKGEDEDVPELVGDFDAASKNETKADEQ |
Sequence similarities
Belongs to the NAC-beta family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length161
- Mass (Da)17,503
- Last updated1996-11-01 v1
- Checksum12E24FF70D12BE94
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX284602 EMBL· GenBank· DDBJ | CCD68179.1 EMBL· GenBank· DDBJ | Genomic DNA |