Q18885 · BTF3_CAEEL

  • Protein
    Transcription factor BTF3 homolog
  • Gene
    icd-1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May be a general transcription factor that can form a stable complex with RNA polymerase II (By similarity).
May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER) (By similarity).
In response to heat stress, plays a role in modulating the unfolded protein response by negatively regulating the accumulation of proteins such as the chaperone protein hsp-4 in the endoplasmic reticulum (PubMed:22957041).
Required to suppress apoptosis in neuronal and intestinal cells to promote development (PubMed:12944970).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentmitochondrion
Cellular Componentnascent polypeptide-associated complex
Cellular Componentnucleus
Biological Processembryo development ending in birth or egg hatching
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of protein localization to endoplasmic reticulum
Biological Processregulation of cellular response to heat

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transcription factor BTF3 homolog
  • Alternative names
    • Inhibitor of cell death 1
    • Nascent polypeptide-associated complex subunit beta
      (NAC-beta
      )

Gene names

    • Name
      icd-1
    • ORF names
      C56C10.8

Organism names

  • Taxonomic identifier
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q18885

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Disruption phenotype

RNAi-mediated knockdown mostly results in embryonic lethality, but embryos that do hatch produce larvae with a large number of apoptotic cell corpses, which are first present at the comma stage of development (PubMed:12944970).
Surviving animals are uncoordinated (PubMed:12944970).
RNAi-mediated knockdown results in increased neuronal and intestinal cell death and a reduced number of male tail rays in larvae (PubMed:12944970).
RNAi-mediated knockdown in larvae results in increased survival and mobility in response to a constant temperature of 36 degrees Celsius, when compared to wild-type (PubMed:22957041).
RNAi-mediated knockdown in adults results in embryos with severe morphological defects and high numbers of enlarged bi-refringent lipofuscin glo-1-positive granules in their gut cells, and increased cell death and degeneration (PubMed:22957041).
These embryos also have increased expression of the endoplasmic reticulum-specific chaperone protein hsp-4 in regions of the embryo that contain gut and epithelial cells (PubMed:22957041).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002135501-161Transcription factor BTF3 homolog

Proteomic databases

PTM databases

Expression

Developmental stage

Expressed throughout development.

Gene expression databases

Interaction

Subunit

May be part of the nascent polypeptide-associated complex (NAC), which is a heterodimer of icd-2 and icd-1 (via NAC-A/B domains).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q18885icd-2 Q86S666EBI-326530, EBI-326549
View interactors in UniProtKB
View CPX-5744 in Complex Portal

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region16-41Disordered
Domain40-105NAC-A/B
Region128-161Disordered

Sequence similarities

Belongs to the NAC-beta family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    161
  • Mass (Da)
    17,503
  • Last updated
    1996-11-01 v1
  • Checksum
    12E24FF70D12BE94
MDSKAIAERIKKLQAQQEHVRIGGKGTPRRKKKVIHKTAAADDKKLQSNLKKLSVTNIPGIEEVNMIKDDGTVIHFNNPKVQTSVPANTFSVTGSADNKQITEMLPGILNQLGPESLTHLKKLANNVTKLGPDGKGEDEDVPELVGDFDAASKNETKADEQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX284602
EMBL· GenBank· DDBJ
CCD68179.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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