Q18434 · GPA17_CAEEL

  • Protein
    Guanine nucleotide-binding protein alpha-17 subunit
  • Gene
    odr-3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:10192394).
This specific G-alpha subunit plays an important role in olfaction and in cilia morphogenesis (PubMed:15342507, PubMed:9459442).
Involved in chemotactic responses to attractants diacetyl, pyrazine, 2,4,5-trimethylthiazole, benzaldehyde, isoamyl alcohol, butanone and 2,3-pentanedione (PubMed:12694294).
Displays a redundant function with gpa-3 in chemotactic responses (PubMed:12694294).
Plays a role in the avoidance response to the noxious chemical quinine in ASH sensory neurons (PubMed:14988722).
Involved in avoidance responses to copper, sodium dodecyl sulfate and linoleic acid (PubMed:12694294).
Involved in osmotic avoidance and mechanosensory responses (PubMed:12694294).
Involved in specifying fan-like morphology of cilia of head sensory neurons AWC (PubMed:9459442).
Plays a role in the detection of preferred food sources by mediating the recognition of food odors in olfactory sensory neurons (PubMed:25009271).

Features

Showing features for binding site.

135650100150200250300350
TypeIDPosition(s)Description
Binding site40-47GTP (UniProtKB | ChEBI)
Binding site47Mg2+ (UniProtKB | ChEBI)
Binding site177-183GTP (UniProtKB | ChEBI)
Binding site183Mg2+ (UniProtKB | ChEBI)
Binding site202-206GTP (UniProtKB | ChEBI)
Binding site271-274GTP (UniProtKB | ChEBI)
Binding site328GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentdendrite
Cellular Componentheterotrimeric G-protein complex
Cellular Componentneuronal cell body
Cellular Componentnon-motile cilium
Molecular FunctionG protein-coupled receptor binding
Molecular FunctionG-protein beta/gamma-subunit complex binding
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionmetal ion binding
Molecular Functionolfactory receptor binding
Biological Processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
Biological Processchemotaxis
Biological Processcilium assembly
Biological Processhyperosmotic response
Biological Processolfactory behavior
Biological Processresponse to odorant
Biological Processsensory perception of smell

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Guanine nucleotide-binding protein alpha-17 subunit
  • Alternative names
    • Odorant response abnormal protein 3

Gene names

    • Name
      odr-3
    • ORF names
      C34D1.3

Organism names

  • Taxonomic identifier
  • Strains
    • Bristol N2
    • PX174
    • PX178
    • PX179
    • AB3
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q18434
  • Secondary accessions
    • C3U544
    • Q867E1
    • Q867N8
    • Q868B7
    • Q86FY4
    • Q86FY5

Proteomes

Organism-specific databases

Subcellular Location

Note: In amphid neurons also weakly expressed in cell body. In phasmid neurons found only in cilia.

Keywords

Phenotypes & Variants

Disruption phenotype

Defective in chemotactic responses to attractants and repellents and in osmotic and mechanosensory avoidance.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis47Loss of chemotactic responses.
Mutagenesis185In ky879; defects in GPCR expression in the AWC neurons.
Mutagenesis206Loss of chemotactic and osmotic avoidance responses.

PTM/Processing

Features

Showing features for initiator methionine, lipidation, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
Lipidation2N-myristoyl glycine
ChainPRO_00002036592-356Guanine nucleotide-binding protein alpha-17 subunit
Lipidation4S-palmitoyl cysteine

Keywords

Proteomic databases

Expression

Tissue specificity

Expressed in sensory neurons in the head and tail. Expressed in amphid AWC neurons, to a lesser extent in AWB and weakly in AWA, ASH and ADF neurons (head sensory neurons). Expressed in phasmid PHA and PHB neurons (tail sensory neurons).

Gene expression databases

    • WBGene00003850Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues

Interaction

Subunit

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain32-356G-alpha
Region35-48G1 motif
Region175-183G2 motif
Region198-207G3 motif
Region267-274G4 motif
Region326-331G5 motif

Sequence similarities

Belongs to the G-alpha family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    356
  • Mass (Da)
    40,434
  • Last updated
    1996-11-01 v1
  • Checksum
    CB9F36F5F4FB95D9
MGSCQSNENSEGNARNKEIEKQLNADKRAGSSIVKLLLLGAGECGKSTVLKQMQILHSNGFTEEEVNEKRAIVYNNTVSAMCTILRAMDGVLHLPLENGQKEAEKAIVMKVQENGEEGEALTEEVSKAIQSLWADPGVKKAFEMRSEYQLPDSAKYFLDNCQRISEPGYRPNDQDILYSRVATTGVVEVKFKIKELDFRVFDVGGQRSERRKWIHCFDNVESIIFITAISEYDQVLFEDETTNRMIESMQLFNSICNSTWFLSTAMILFMNKKDLFMEKIQRVNITTAFPDYEGGQNYEEAVSFIKQKFAELNLNPDKKTIYMHETCATDTNQVQLVISSVIDTIIQKNLQKAGMM

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY008142
EMBL· GenBank· DDBJ
AAG32095.1
EMBL· GenBank· DDBJ
mRNA
FJ455729
EMBL· GenBank· DDBJ
ACQ43989.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ455730
EMBL· GenBank· DDBJ
ACQ43990.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ455731
EMBL· GenBank· DDBJ
ACQ43991.1
EMBL· GenBank· DDBJ
Genomic DNA
BX284605
EMBL· GenBank· DDBJ
CAB01489.1
EMBL· GenBank· DDBJ
Genomic DNA
AY146558
EMBL· GenBank· DDBJ
AAN78230.1
EMBL· GenBank· DDBJ
Genomic DNA
AY146559
EMBL· GenBank· DDBJ
AAN78231.1
EMBL· GenBank· DDBJ
Genomic DNA
AY146560
EMBL· GenBank· DDBJ
AAN78232.1
EMBL· GenBank· DDBJ
Genomic DNA
AY146561
EMBL· GenBank· DDBJ
AAN78233.1
EMBL· GenBank· DDBJ
Genomic DNA
AY146562
EMBL· GenBank· DDBJ
AAN78234.1
EMBL· GenBank· DDBJ
Genomic DNA
AY146563
EMBL· GenBank· DDBJ
AAN78235.1
EMBL· GenBank· DDBJ
Genomic DNA
AY146564
EMBL· GenBank· DDBJ
AAN78236.1
EMBL· GenBank· DDBJ
Genomic DNA
AY146565
EMBL· GenBank· DDBJ
AAN78237.1
EMBL· GenBank· DDBJ
Genomic DNA
AY146566
EMBL· GenBank· DDBJ
AAN78238.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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