Q18225 · FLH2_CAEEL
- ProteinFLYWCH transcription factor 2
- Geneflh-2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids470 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Probable transcription factor (PubMed:18794349).
May bind to the promoters of target genes, including micro-RNA genes, in order to repress expression, and acting redundantly with flh-1 and flh-3 (PubMed:18794349).
May bind to the promoters of target genes, including micro-RNA genes, in order to repress expression, and acting redundantly with flh-1 and flh-3 (PubMed:18794349).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | metal ion binding | |
Molecular Function | sequence-specific DNA binding | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | nematode larval development |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameFLYWCH transcription factor 2
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ18225
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Disruption phenotype
Knockout causes a nearly wild-type phenotype, but a few young larvae have morphological abnormalities (PubMed:18794349).
In a flh-1 mutant background, L1 larvae have severe morphological abnormalities and/or appear necrotic, and 100% die before reaching the L2 larval stage (PubMed:18794349).
Embryos exhibit significantly lower expression of lin-14, and overexpression of micro-RNAs, including lin-4, mir-48, mir-241, and mir-34 (PubMed:18794349).
In a flh-3 mutant background, embryos exhibit significant overexpression of micro-RNAs, including lin-4, mir-48, mir-230, and mir-65 (PubMed:18794349).
RNAi-mediated knockdown has no obvious phenotype, but causes precocious embryonic expression of micro-RNA lin-4, when combined with simultaneous RNAi-mediated knockdown of flh-1 (PubMed:18794349).
In a flh-1 mutant background, L1 larvae have severe morphological abnormalities and/or appear necrotic, and 100% die before reaching the L2 larval stage (PubMed:18794349).
Embryos exhibit significantly lower expression of lin-14, and overexpression of micro-RNAs, including lin-4, mir-48, mir-241, and mir-34 (PubMed:18794349).
In a flh-3 mutant background, embryos exhibit significant overexpression of micro-RNAs, including lin-4, mir-48, mir-230, and mir-65 (PubMed:18794349).
RNAi-mediated knockdown has no obvious phenotype, but causes precocious embryonic expression of micro-RNA lin-4, when combined with simultaneous RNAi-mediated knockdown of flh-1 (PubMed:18794349).
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000453578 | 1-470 | FLYWCH transcription factor 2 | |||
Sequence: MVDTMMNTNTDGVTAVPPIFPLPSTTPNRNNNNELAMLAQKQIVAGLLLQQPTIVQAAVNGTNSQKHLADIDYTNVIQTLQALGTTNLKAFSLLLDPQSQTSQLISEDTRPSASSSPSSTATAVSNSGQSNATSTSSSSTEPEYKPRNVREKVYADGYIMSFDKKSCCGTKEFWRCERKNDCNARMHSDINTREIVRKLHPHNHEKPSPEELAFYEQDFSTLHPNYCHPVKSINRSYMQRKLSRASHVSQALPIAPQQIKAEPMEVDTTNQTIQNFQQNNNLMLLASINAAATAAAAATSAGISPPVVGQKRVSTTVMPITLKSQRTTPKEEEDSSQLMSQEEFRITYELTKKLMEMMKPKTEIGVRWQGDEGSILLFLSHDNGAEENVFFPVVVMNRDEKSLITALEGFTGKRCEGKLALCYSQRVNVLVHEALISNWTHGKLFLVNTDAPALWRLTPVDAFGEPLNHV |
Proteomic databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 102-143 | Polar residues | ||||
Sequence: SQLISEDTRPSASSSPSSTATAVSNSGQSNATSTSSSSTEPE | ||||||
Region | 102-148 | Disordered | ||||
Sequence: SQLISEDTRPSASSSPSSTATAVSNSGQSNATSTSSSSTEPEYKPRN | ||||||
Zinc finger | 145-204 | FLYWCH-type | ||||
Sequence: KPRNVREKVYADGYIMSFDKKSCCGTKEFWRCERKNDCNARMHSDINTREIVRKLHPHNH |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length470
- Mass (Da)52,068
- Last updated2003-03-01 v2
- ChecksumFD3EB53080521712
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 102-143 | Polar residues | ||||
Sequence: SQLISEDTRPSASSSPSSTATAVSNSGQSNATSTSSSSTEPE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX284603 EMBL· GenBank· DDBJ | CCD65726.1 EMBL· GenBank· DDBJ | Genomic DNA |