Q18225 · FLH2_CAEEL

  • Protein
    FLYWCH transcription factor 2
  • Gene
    flh-2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Probable transcription factor (PubMed:18794349).
May bind to the promoters of target genes, including micro-RNA genes, in order to repress expression, and acting redundantly with flh-1 and flh-3 (PubMed:18794349).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionmetal ion binding
Molecular Functionsequence-specific DNA binding
Biological Processnegative regulation of DNA-templated transcription
Biological Processnematode larval development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    FLYWCH transcription factor 2

Gene names

    • Name
      flh-2
    • ORF names
      C26E6.2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q18225

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Disruption phenotype

Knockout causes a nearly wild-type phenotype, but a few young larvae have morphological abnormalities (PubMed:18794349).
In a flh-1 mutant background, L1 larvae have severe morphological abnormalities and/or appear necrotic, and 100% die before reaching the L2 larval stage (PubMed:18794349).
Embryos exhibit significantly lower expression of lin-14, and overexpression of micro-RNAs, including lin-4, mir-48, mir-241, and mir-34 (PubMed:18794349).
In a flh-3 mutant background, embryos exhibit significant overexpression of micro-RNAs, including lin-4, mir-48, mir-230, and mir-65 (PubMed:18794349).
RNAi-mediated knockdown has no obvious phenotype, but causes precocious embryonic expression of micro-RNA lin-4, when combined with simultaneous RNAi-mediated knockdown of flh-1 (PubMed:18794349).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004535781-470FLYWCH transcription factor 2

Proteomic databases

Expression

Developmental stage

Expressed in the embryo (at protein level) (PubMed:18794349).
Expressed in most embryonic cells starting at gastrulation and also in head and tail cells during the larval and adult stages (PubMed:18794349).

Gene expression databases

    • WBGene00016138Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region, zinc finger.

TypeIDPosition(s)Description
Compositional bias102-143Polar residues
Region102-148Disordered
Zinc finger145-204FLYWCH-type

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    470
  • Mass (Da)
    52,068
  • Last updated
    2003-03-01 v2
  • Checksum
    FD3EB53080521712
MVDTMMNTNTDGVTAVPPIFPLPSTTPNRNNNNELAMLAQKQIVAGLLLQQPTIVQAAVNGTNSQKHLADIDYTNVIQTLQALGTTNLKAFSLLLDPQSQTSQLISEDTRPSASSSPSSTATAVSNSGQSNATSTSSSSTEPEYKPRNVREKVYADGYIMSFDKKSCCGTKEFWRCERKNDCNARMHSDINTREIVRKLHPHNHEKPSPEELAFYEQDFSTLHPNYCHPVKSINRSYMQRKLSRASHVSQALPIAPQQIKAEPMEVDTTNQTIQNFQQNNNLMLLASINAAATAAAAATSAGISPPVVGQKRVSTTVMPITLKSQRTTPKEEEDSSQLMSQEEFRITYELTKKLMEMMKPKTEIGVRWQGDEGSILLFLSHDNGAEENVFFPVVVMNRDEKSLITALEGFTGKRCEGKLALCYSQRVNVLVHEALISNWTHGKLFLVNTDAPALWRLTPVDAFGEPLNHV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias102-143Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX284603
EMBL· GenBank· DDBJ
CCD65726.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp