Q17UC4 · Q17UC4_HPV53
- ProteinProtein E6
- GeneE6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids154 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Plays a major role in the induction and maintenance of cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity. Sequesters tumor suppressor TP53 in the host cytoplasm and modulates its activity by interacting with host EP300 that results in the reduction of TP53 acetylation and activation. In turn, apoptosis induced by DNA damage is inhibited. E6 protects also host keratinocytes from apoptosis by mediating the degradation of host BAK1. May also inhibit host immune response.
Miscellaneous
Belongs to the low risk human alphapapillomavirus family. The cancer-causing human papillomavirus E6 protein has a unique carboxy terminal PDZ domain containing substrate but low risk E6s do not possess this domain.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | host cell cytoplasm | |
Cellular Component | host cell nucleus | |
Molecular Function | DNA binding | |
Molecular Function | metal ion binding | |
Biological Process | DNA-templated transcription | |
Biological Process | regulation of DNA-templated transcription | |
Biological Process | symbiont-mediated perturbation of host apoptosis | |
Biological Process | symbiont-mediated perturbation of host ubiquitin-like protein modification | |
Biological Process | symbiont-mediated suppression of host innate immune response | |
Biological Process | symbiont-mediated suppression of host type I interferon-mediated signaling pathway | |
Biological Process | virus-mediated perturbation of host defense response |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameProtein E6
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageViruses > Monodnaviria > Shotokuvirae > Cossaviricota > Papovaviricetes > Zurhausenvirales > Papillomaviridae > Firstpapillomavirinae > Alphapapillomavirus > Alphapapillomavirus 6
- Virus hosts
Accessions
- Primary accessionQ17UC4
Subcellular Location
Expression
Keywords
- Developmental stage
Interaction
Subunit
Forms homodimers. Interacts with ubiquitin-protein ligase UBE3A/E6-AP; this interaction stimulates UBE3A ubiquitin activity. Interacts with host TP53 and EP300; this interaction inhibits TP53 activity.
Sequence
- Sequence statusComplete
- Length154
- Mass (Da)18,168
- Last updated2006-07-25 v1
- MD5 ChecksumAE7AA4F99A6CA8AE4BF2719946F6F1A7
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HM585458 EMBL· GenBank· DDBJ | AEI54138.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM585492 EMBL· GenBank· DDBJ | AEI54150.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU951269 EMBL· GenBank· DDBJ | ANY26608.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU951274 EMBL· GenBank· DDBJ | ANY26618.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU951276 EMBL· GenBank· DDBJ | ANY26622.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LR861876 EMBL· GenBank· DDBJ | CAD1807287.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LR861884 EMBL· GenBank· DDBJ | CAD1807355.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LR862024 EMBL· GenBank· DDBJ | CAD1814155.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283307 EMBL· GenBank· DDBJ | CAK55420.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283308 EMBL· GenBank· DDBJ | CAK55421.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283309 EMBL· GenBank· DDBJ | CAK55422.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283310 EMBL· GenBank· DDBJ | CAK55423.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283311 EMBL· GenBank· DDBJ | CAK55424.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283327 EMBL· GenBank· DDBJ | CAK55440.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283328 EMBL· GenBank· DDBJ | CAK55441.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283329 EMBL· GenBank· DDBJ | CAK55442.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283376 EMBL· GenBank· DDBJ | CAK55489.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283377 EMBL· GenBank· DDBJ | CAK55490.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283378 EMBL· GenBank· DDBJ | CAK55491.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283379 EMBL· GenBank· DDBJ | CAK55492.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283380 EMBL· GenBank· DDBJ | CAK55493.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283381 EMBL· GenBank· DDBJ | CAK55494.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283382 EMBL· GenBank· DDBJ | CAK55495.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283383 EMBL· GenBank· DDBJ | CAK55496.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283384 EMBL· GenBank· DDBJ | CAK55497.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283385 EMBL· GenBank· DDBJ | CAK55498.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283386 EMBL· GenBank· DDBJ | CAK55499.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283387 EMBL· GenBank· DDBJ | CAK55500.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283388 EMBL· GenBank· DDBJ | CAK55501.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283389 EMBL· GenBank· DDBJ | CAK55502.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283390 EMBL· GenBank· DDBJ | CAK55503.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283391 EMBL· GenBank· DDBJ | CAK55504.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM283392 EMBL· GenBank· DDBJ | CAK55505.1 EMBL· GenBank· DDBJ | Genomic DNA |