Essential maintenance is planned to begin on Tue Jan 28 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ during this time.

Q17UC4 · Q17UC4_HPV53

Function

function

Plays a major role in the induction and maintenance of cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity. Sequesters tumor suppressor TP53 in the host cytoplasm and modulates its activity by interacting with host EP300 that results in the reduction of TP53 acetylation and activation. In turn, apoptosis induced by DNA damage is inhibited. E6 protects also host keratinocytes from apoptosis by mediating the degradation of host BAK1. May also inhibit host immune response.

Miscellaneous

Belongs to the low risk human alphapapillomavirus family. The cancer-causing human papillomavirus E6 protein has a unique carboxy terminal PDZ domain containing substrate but low risk E6s do not possess this domain.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell cytoplasm
Cellular Componenthost cell nucleus
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Biological ProcessDNA-templated transcription
Biological Processregulation of DNA-templated transcription
Biological Processsymbiont-mediated perturbation of host apoptosis
Biological Processsymbiont-mediated perturbation of host ubiquitin-like protein modification
Biological Processsymbiont-mediated suppression of host innate immune response
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein E6

Gene names

    • Name
      E6

Organism names

  • Taxonomic identifier
  • Strains
    • 115
    • 250
    • 286
    • 327
    • 328
  • Taxonomic lineage
    Viruses > Monodnaviria > Shotokuvirae > Cossaviricota > Papovaviricetes > Zurhausenvirales > Papillomaviridae > Firstpapillomavirinae > Alphapapillomavirus > Alphapapillomavirus 6

Accessions

  • Primary accession
    Q17UC4

Subcellular Location

Keywords

Expression

Keywords

Interaction

Subunit

Forms homodimers. Interacts with ubiquitin-protein ligase UBE3A/E6-AP; this interaction stimulates UBE3A ubiquitin activity. Interacts with host TP53 and EP300; this interaction inhibits TP53 activity.

Structure

3D structure databases

Family & Domains

Features

Showing features for zinc finger.

TypeIDPosition(s)Description
Zinc finger34-70
Zinc finger107-143

Sequence similarities

Belongs to the papillomaviridae E6 protein family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    154
  • Mass (Da)
    18,168
  • Last updated
    2006-07-25 v1
  • MD5 Checksum
    AE7AA4F99A6CA8AE4BF2719946F6F1A7
MDRQLFENTEERPRTLHQLCEVVNKPLLELQLGCVFCKKALTASEVYNFAYTDLRVVYRDGYPYGVCKFCLLFYSKVRKLRYYNCSVYGASLEALTKKKLSDLSIRCYRCQHPLTPEEKQLHCDYKKRFHKISHMWTGSCLTCWRHTTATESAV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HM585458
EMBL· GenBank· DDBJ
AEI54138.1
EMBL· GenBank· DDBJ
Genomic DNA
HM585492
EMBL· GenBank· DDBJ
AEI54150.1
EMBL· GenBank· DDBJ
Genomic DNA
KU951269
EMBL· GenBank· DDBJ
ANY26608.1
EMBL· GenBank· DDBJ
Genomic DNA
KU951274
EMBL· GenBank· DDBJ
ANY26618.1
EMBL· GenBank· DDBJ
Genomic DNA
KU951276
EMBL· GenBank· DDBJ
ANY26622.1
EMBL· GenBank· DDBJ
Genomic DNA
LR861876
EMBL· GenBank· DDBJ
CAD1807287.1
EMBL· GenBank· DDBJ
Genomic DNA
LR861884
EMBL· GenBank· DDBJ
CAD1807355.1
EMBL· GenBank· DDBJ
Genomic DNA
LR862024
EMBL· GenBank· DDBJ
CAD1814155.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283307
EMBL· GenBank· DDBJ
CAK55420.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283308
EMBL· GenBank· DDBJ
CAK55421.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283309
EMBL· GenBank· DDBJ
CAK55422.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283310
EMBL· GenBank· DDBJ
CAK55423.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283311
EMBL· GenBank· DDBJ
CAK55424.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283327
EMBL· GenBank· DDBJ
CAK55440.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283328
EMBL· GenBank· DDBJ
CAK55441.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283329
EMBL· GenBank· DDBJ
CAK55442.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283376
EMBL· GenBank· DDBJ
CAK55489.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283377
EMBL· GenBank· DDBJ
CAK55490.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283378
EMBL· GenBank· DDBJ
CAK55491.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283379
EMBL· GenBank· DDBJ
CAK55492.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283380
EMBL· GenBank· DDBJ
CAK55493.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283381
EMBL· GenBank· DDBJ
CAK55494.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283382
EMBL· GenBank· DDBJ
CAK55495.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283383
EMBL· GenBank· DDBJ
CAK55496.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283384
EMBL· GenBank· DDBJ
CAK55497.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283385
EMBL· GenBank· DDBJ
CAK55498.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283386
EMBL· GenBank· DDBJ
CAK55499.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283387
EMBL· GenBank· DDBJ
CAK55500.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283388
EMBL· GenBank· DDBJ
CAK55501.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283389
EMBL· GenBank· DDBJ
CAK55502.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283390
EMBL· GenBank· DDBJ
CAK55503.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283391
EMBL· GenBank· DDBJ
CAK55504.1
EMBL· GenBank· DDBJ
Genomic DNA
AM283392
EMBL· GenBank· DDBJ
CAK55505.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help