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Q17RB8 · LONF1_HUMAN

  • Protein
    LON peptidase N-terminal domain and RING finger protein 1
  • Gene
    LONRF1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Molecular Functionmetal ion binding
Molecular Functionubiquitin protein ligase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    LON peptidase N-terminal domain and RING finger protein 1
  • Alternative names
    • RING finger protein 191

Gene names

    • Name
      LONRF1
    • Synonyms
      RNF191

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q17RB8
  • Secondary accessions
    • B4DM29
    • B4DU84
    • Q8TEA0
    • Q9BSV1

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_058706265in dbSNP:rs1139354

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 872 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), modified residue.

Type
IDPosition(s)Source
Description
ChainPRO_00002776691-773UniProtLON peptidase N-terminal domain and RING finger protein 1
Modified residue (large scale data)413PRIDEPhosphoserine
Modified residue431UniProtPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY Q17RB8ADAMTSL4 Q6UY14-36EBI-2341787, EBI-10173507
BINARY Q17RB8ALAS1 P131966EBI-2341787, EBI-3905054
BINARY Q17RB8AP2B1 P63010-23EBI-2341787, EBI-11529439
BINARY Q17RB8ATG9A Q7Z3C63EBI-2341787, EBI-727146
BINARY Q17RB8AVPI1 Q5T6863EBI-2341787, EBI-8640233
BINARY Q17RB8BYSL Q138958EBI-2341787, EBI-358049
BINARY Q17RB8C4orf17 Q53FE43EBI-2341787, EBI-715110
BINARY Q17RB8CALCOCO2 Q131373EBI-2341787, EBI-739580
BINARY Q17RB8CBLL2 Q8N7E23EBI-2341787, EBI-12196065
BINARY Q17RB8CDKN2D P552733EBI-2341787, EBI-745859
BINARY Q17RB8CFP P279183EBI-2341787, EBI-9038570
BINARY Q17RB8CRX O431865EBI-2341787, EBI-748171
BINARY Q17RB8CYSRT1 A8MQ033EBI-2341787, EBI-3867333
BINARY Q17RB8DVL3 Q929973EBI-2341787, EBI-739789
BINARY Q17RB8EFHC2 Q5JST66EBI-2341787, EBI-2349927
BINARY Q17RB8FLACC1 Q96Q35-23EBI-2341787, EBI-11533409
BINARY Q17RB8GABPB2 Q8TAK53EBI-2341787, EBI-8468945
BINARY Q17RB8GORASP1 Q9BQQ36EBI-2341787, EBI-2561458
BINARY Q17RB8GORASP2 Q9H8Y810EBI-2341787, EBI-739467
BINARY Q17RB8GPRASP3 Q6PI773EBI-2341787, EBI-11519926
BINARY Q17RB8HLX Q147743EBI-2341787, EBI-6678255
BINARY Q17RB8HOXA1 P496393EBI-2341787, EBI-740785
BINARY Q17RB8IHO1 Q8IYA86EBI-2341787, EBI-8638439
BINARY Q17RB8IKZF2 Q9UKS73EBI-2341787, EBI-3893057
BINARY Q17RB8IKZF3 Q9UKT93EBI-2341787, EBI-747204
BINARY Q17RB8IQCF2 Q8IXL93EBI-2341787, EBI-10238842
BINARY Q17RB8KAT5 Q929933EBI-2341787, EBI-399080
BINARY Q17RB8KATNBL1 Q9H0793EBI-2341787, EBI-715394
BINARY Q17RB8KCTD21 Q4G0X43EBI-2341787, EBI-11976683
BINARY Q17RB8KCTD9 Q7L2736EBI-2341787, EBI-4397613
BINARY Q17RB8KRT31 Q153236EBI-2341787, EBI-948001
BINARY Q17RB8KRT35 Q927643EBI-2341787, EBI-1058674
BINARY Q17RB8KRT75 O956783EBI-2341787, EBI-2949715
BINARY Q17RB8KRTAP1-3 Q8IUG13EBI-2341787, EBI-11749135
BINARY Q17RB8KRTAP13-3 Q3SY463EBI-2341787, EBI-10241252
BINARY Q17RB8KRTAP19-6 Q3LI703EBI-2341787, EBI-12805508
BINARY Q17RB8KRTAP19-7 Q3SYF93EBI-2341787, EBI-10241353
BINARY Q17RB8KRTAP3-3 Q9BYR63EBI-2341787, EBI-3957694
BINARY Q17RB8KRTAP6-1 Q3LI643EBI-2341787, EBI-12111050
BINARY Q17RB8LGALS9B Q3B8N23EBI-2341787, EBI-10240775
BINARY Q17RB8LHX2 P504583EBI-2341787, EBI-12179869
BINARY Q17RB8LHX4 Q969G23EBI-2341787, EBI-2865388
BINARY Q17RB8LNX1 Q8TBB13EBI-2341787, EBI-739832
BINARY Q17RB8MAGED1 Q9Y5V33EBI-2341787, EBI-716006
BINARY Q17RB8MID2 Q9UJV3-23EBI-2341787, EBI-10172526
BINARY Q17RB8MRPL38 Q96DV43EBI-2341787, EBI-720441
BINARY Q17RB8MTMR3 Q136153EBI-2341787, EBI-371938
BINARY Q17RB8MYOZ3 Q8TDC03EBI-2341787, EBI-5662487
BINARY Q17RB8NR4A1 P227363EBI-2341787, EBI-721550
BINARY Q17RB8NTAQ1 Q96HA84EBI-2341787, EBI-741158
BINARY Q17RB8OOEP A6NGQ23EBI-2341787, EBI-18583589
BINARY Q17RB8PATZ1 Q9HBE1-43EBI-2341787, EBI-11022007
BINARY Q17RB8PAX5 Q025483EBI-2341787, EBI-296331
BINARY Q17RB8PAX6 P263673EBI-2341787, EBI-747278
BINARY Q17RB8PAX8 Q067103EBI-2341787, EBI-2683132
BINARY Q17RB8PICK1 Q9NRD53EBI-2341787, EBI-79165
BINARY Q17RB8PLSCR1 Q8WVK13EBI-2341787, EBI-10238872
BINARY Q17RB8POU6F2 P784243EBI-2341787, EBI-12029004
BINARY Q17RB8PPP1R3C Q9UQK13EBI-2341787, EBI-2506727
BINARY Q17RB8PRDM6 Q9NQX03EBI-2341787, EBI-11320284
BINARY Q17RB8PRR35 P0CG203EBI-2341787, EBI-11986293
BINARY Q17RB8PSMA1 P257863EBI-2341787, EBI-359352
BINARY Q17RB8RBPMS Q930623EBI-2341787, EBI-740322
BINARY Q17RB8RIMBP3 Q9UFD93EBI-2341787, EBI-10182375
BINARY Q17RB8RPRD1A Q96P16-33EBI-2341787, EBI-12840198
BINARY Q17RB8SFN P319473EBI-2341787, EBI-476295
BINARY Q17RB8SLU7 O953913EBI-2341787, EBI-750559
BINARY Q17RB8SPRY2 O435973EBI-2341787, EBI-742487
BINARY Q17RB8STAU1 O957936EBI-2341787, EBI-358174
BINARY Q17RB8STX11 O755583EBI-2341787, EBI-714135
BINARY Q17RB8TASOR2 Q5VWN63EBI-2341787, EBI-745958
BINARY Q17RB8TBX19 O608063EBI-2341787, EBI-12096770
BINARY Q17RB8TRAF2 Q129333EBI-2341787, EBI-355744
BINARY Q17RB8TRIM27 P143733EBI-2341787, EBI-719493
BINARY Q17RB8TRIM42 Q8IWZ58EBI-2341787, EBI-5235829
BINARY Q17RB8TRIM8 Q9BZR93EBI-2341787, EBI-2340370
BINARY Q17RB8UBE2I Q7KZS03EBI-2341787, EBI-10180829
BINARY Q17RB8UBE2L6 O149337EBI-2341787, EBI-2129974
BINARY Q17RB8VGLL1 Q999903EBI-2341787, EBI-11983165
BINARY Q17RB8WDR83 Q9BRX93EBI-2341787, EBI-7705033
BINARY Q17RB8XIAP P981707EBI-2341787, EBI-517127
BINARY Q17RB8ZFP90 Q8TF473EBI-2341787, EBI-11419867
BINARY Q17RB8ZNF426 Q9BUY53EBI-2341787, EBI-743265
BINARY Q17RB8ZNF653 Q96CK03EBI-2341787, EBI-12217757
BINARY Q17RB8ZNF774 Q6NX453EBI-2341787, EBI-10251462
BINARY Q17RB8ZNHIT2 Q9UHR63EBI-2341787, EBI-2557592

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, repeat, zinc finger, compositional bias, domain.

Type
IDPosition(s)Description
Region1-29Disordered
Repeat48-81TPR 1
Zinc finger123-159RING-type 1
Repeat212-244TPR 2
Repeat246-278TPR 3
Repeat279-312TPR 4
Compositional bias359-375Polar residues
Region359-388Disordered
Zinc finger479-517RING-type 2
Domain558-768Lon N-terminal

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q17RB8-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    773
  • Mass (Da)
    86,725
  • Last updated
    2009-09-01 v2
  • MD5 Checksum
    BEE4E4E47C3575B794E546FE45C6CD46
MSSPAVARTSPGGSREMAPAPQGRGRFWEVGGGSGHRLERAAAESERWELLLRRGELLALGGHLKGALEAFAAALRRGAPARPECLGALVDCLVFNYRLRHGLGWSAAPVAGADGGAGGLLRCLGCRGFLSEPVTVPCGHSYCRRCLRRELRARCRLCRDRLPPATASATDAEGTAPRPPPLAAAIAASDFRTSVVLNHLAEKWFPGQRERARAAGRLGELLHQGRYREALAAACEALRAEPSDLIVKIYRAESYAGLQEFKAAIEDLNAVLFQLPDWPEVYFRKGKVLCDAGFLGDALQLFLQCLALDEDFAPAKLQVQKILCDLLLPENLKEGLKESSWSSLPCTKNRPFDFHSVMEESQSLNEPSPKQSEEIPEVTSEPVKGSLNRAQSAQSINSTEMPAREDCLKRVSSEPVLSVQEKGVLLKRKLSLLEQDVIVNEDGRNKLKKQGETPNEVCMFSLAYGDIPEELIDVSDFECSLCMRLFFEPVTTPCGHSFCKNCLERCLDHAPYCPLCKESLKEYLADRRYCVTQLLEELIVKYLPDELSERKKIYDEETAELSHLTKNVPIFVCTMAYPTVPCPLHVFEPRYRLMIRRSIQTGTKQFGMCVSDTQNSFADYGCMLQIRNVHFLPDGRSVVDTVGGKRFRVLKRGMKDGYCTADIEYLEDVKVENEDEIKNLRELHDLVYSQACSWFQNLRDRFRSQILQHFGSMPEREENLQAAPNGPAWCWWLLAVLPVDPRYQLSVLSMKSLKERLTKIQHILTYFSRDQSK

Q17RB8-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H7C5V9H7C5V9_HUMANLONRF1376
E9PRX6E9PRX6_HUMANLONRF159
E9PQH4E9PQH4_HUMANLONRF1199
A0A0C4DGE8A0A0C4DGE8_HUMANLONRF1416
A0AAG2TK99A0AAG2TK99_HUMANLONRF1773
A0AAG2TH20A0AAG2TH20_HUMANLONRF1416
A0AAG2TH09A0AAG2TH09_HUMANLONRF1376

Sequence caution

The sequence AAI17382.1 differs from that shown. Reason: Erroneous initiation
The sequence AAI17386.1 differs from that shown. Reason: Erroneous initiation
The sequence BAB85052.1 differs from that shown. Reason: Frameshift
The sequence BAG59741.1 differs from that shown. Reason: Frameshift
The sequence BAG62246.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for compositional bias, alternative sequence, sequence conflict.

Type
IDPosition(s)Description
Compositional bias359-375Polar residues
Alternative sequenceVSP_037971452-462in isoform 2
Sequence conflict663in Ref. 2; BAG62246
Sequence conflict773in Ref. 2; BAG59741

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC123777
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AK074329
EMBL· GenBank· DDBJ
BAB85052.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AK297266
EMBL· GenBank· DDBJ
BAG59741.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AK300538
EMBL· GenBank· DDBJ
BAG62246.1
EMBL· GenBank· DDBJ
mRNA Different initiation
BC004538
EMBL· GenBank· DDBJ
AAH04538.2
EMBL· GenBank· DDBJ
mRNA
BC117381
EMBL· GenBank· DDBJ
AAI17382.1
EMBL· GenBank· DDBJ
mRNA Different initiation
BC117385
EMBL· GenBank· DDBJ
AAI17386.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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