Q17602 · NU214_CAEEL

  • Protein
    Nuclear pore complex protein 14
  • Gene
    npp-14
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (By similarity).
Plays a role in apoptosis by tethering caspase ced-3 to the nuclear membrane preventing its autoprocessing in absence of ced-4

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnuclear membrane
Cellular Componentnuclear pore
Molecular Functioncaspase binding
Molecular Functionnuclear localization sequence binding
Molecular Functionstructural constituent of nuclear pore
Biological Processinhibition of cysteine-type endopeptidase activity involved in apoptotic process
Biological ProcessmRNA transport
Biological Processnegative regulation of execution phase of apoptosis
Biological Processprotein import into nucleus
Biological ProcessRNA export from nucleus

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Nuclear pore complex protein 14
  • Alternative names
    • Nuclear pore complex protein Nup214
    • Nucleoporin npp-14

Gene names

    • Name
      npp-14
    • ORF names
      C03D6.4

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q17602

Proteomes

Organism-specific databases

Subcellular Location

Nucleus membrane
; Peripheral membrane protein
Note: Cytoplasmic side of the nuclear pore complex (By similarity).
Co-localizes with caspase ced-3 to the perinuclear region in germ cells

Keywords

Phenotypes & Variants

Disruption phenotype

RNAi-mediated knockdown causes no visible phenotype (PubMed:12937276).
Simultaneous knockdown of npp-2 results in embryonic lethality (PubMed:12937276).
RNAi-mediated knockdown in a ced-1 (e1735) and ced-3 (n718) double mutant background partially restores embryonic cell apoptosis (PubMed:27723735).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004401641-1390Nuclear pore complex protein 14

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with caspase ced-3 (via propeptide); the interaction tethers ced-3 to the nuclear membrane and prevents its autoprocessing in absence of ced-4.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, repeat.

TypeIDPosition(s)Description
Region434-530Disordered
Compositional bias436-453Polar residues
Compositional bias464-519Polar residues
Compositional bias851-871Polar residues
Region851-874Disordered
Region985-1118Disordered
Compositional bias992-1038Basic and acidic residues
Compositional bias1041-1118Polar residues
Repeat1073-10741
Region1073-137317 X 2 AA repeats of F-G
Repeat1091-10922
Repeat1111-11123
Repeat1122-11234
Repeat1125-11265
Repeat1163-11646
Repeat1166-11677
Repeat1178-11798
Region1183-1280Disordered
Compositional bias1211-1280Polar residues
Repeat1244-12459
Repeat1283-128410
Repeat1289-129011
Repeat1295-129612
Repeat1300-130113
Repeat1315-131614
Region1342-1390Disordered
Repeat1344-134515
Repeat1357-135816
Repeat1372-137317

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,390
  • Mass (Da)
    147,968
  • Last updated
    1996-11-01 v1
  • Checksum
    2FD1DB4D3B7E43D3
MSNEDVAEDVSQVTDFHFHTCRKFRLFSSKSDGYSQNEINIRNRVATSSQLGVTFVTVNSNQLSCFHTKSLLGYKITRENMNVEVTDLPIKTIRLHGVVLINDMGVNSDGTVLGVLHTKNNDVSVDVFDIKKICTSSSIEPFKPLCTTRVGTEQINQGSCLEWNPAFPDTFAASSTDRSILVAKINVQSPANQKLVGIGKFGAVTTAISWSPKGKQLTIGDSLGKIVQLKPELEVVRSQHGPENKPNYGRITGLCWLATTEWLVSLENGTDQDAYLMRCKKDKPTEWIQFHELSYSSSKWPLPPQLFPATQLLVDWNVVIVGNSKTSEISTVGKRDDWQTWVPVEGESIYLPTTSSGKDTVPIGVAVDRSMTDEVLLNPDGSQRHRPSPLVLCLTNDGILTAHHIISTFAAHIPCQMSSQNLAINDLKKLQFDSQKPISAPPSDQTPVTKPSTVFGQKPEAETLKSSLVGSPSSVQTPKPSSSLFNPKSIASNIETSQLTESKPSTPAAPSSQPKIASTPKSEAIPKISDKTLEHKKAELIATKKQVLIERMDKINDSMAGAKDATMKLSFAVGKVKTTIMECADVVRASLGDSKEVMDELKNLILSIERMSDRTQHTVKEMDFEIDEKMELVAGVEDGNQVLEKLRNMSETEKLMRFNKLETAADLLNGKYEECSDLIKKLRMSLSEKESLRKQAILSPLRLSSNLNQLRSGSETELALKVMRNVSKIIMDTREQIQRTELEFVRFQRDVKFQNFKKGKENLNFTQPLEMSSLDGDAPQGKSLTDAESIKVRQALVNQIQKRGIVKTRNVIVESYKKSENSAAMKNDLLDTSNLSNAILKLSMTPRRVMPSSSLFSASPSTPSTKSDAATQADEPPIVKTVVVTVESPAKPIASAPAVSSPLIKLNTTTATTTMTTPKVTVPKEEANKTQDQKPIISTPASSSIFSSGSLFGTKTQTPLVSKEESTLTTGVPSLINSSLSISPQEIEKASSKVETLNKTEEVKDEKSENEVTPDLKSEEPKSLETKVKEEPKPAVQTPVKEEETGSNIQKTPSFSFNSTTTPKSTSSTSSIFGGGLKTQTPSSSNSTNIFGARTTTTATPTPASNTSSIFGGGSKAASSPFGSFGQAGCQPAKTSNPATSTASVTFSFNTGATSASAKPAGFGSFGAGASAKPSSVFGGSVTAPTVPNVDDGMEDDSMANGGGSGGFMSGLGNARTSNTSGGNNPFAPKTSTGTSASSSSWLFGGGGNQQQQQQQKPSFSFNTAGSSAQQASAPATGTSSVFGGAPKFGSQPAFGAKPFGGGANAGLSKNASIFGGATSSTTNNPATGGFAQFASGQKTSSLFGGGATPQTNTSIFGGGANTTPAPTSSVFGGGASANANKPTSFTSWR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias436-453Polar residues
Compositional bias464-519Polar residues
Compositional bias851-871Polar residues
Compositional bias992-1038Basic and acidic residues
Compositional bias1041-1118Polar residues
Compositional bias1211-1280Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX284601
EMBL· GenBank· DDBJ
CAA99763.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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