Q17602 · NU214_CAEEL
- ProteinNuclear pore complex protein 14
- Genenpp-14
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1390 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (By similarity).
Plays a role in apoptosis by tethering caspase ced-3 to the nuclear membrane preventing its autoprocessing in absence of ced-4
Plays a role in apoptosis by tethering caspase ced-3 to the nuclear membrane preventing its autoprocessing in absence of ced-4
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | nuclear membrane | |
Cellular Component | nuclear pore | |
Molecular Function | caspase binding | |
Molecular Function | nuclear localization sequence binding | |
Molecular Function | structural constituent of nuclear pore | |
Biological Process | inhibition of cysteine-type endopeptidase activity involved in apoptotic process | |
Biological Process | mRNA transport | |
Biological Process | negative regulation of execution phase of apoptosis | |
Biological Process | protein import into nucleus | |
Biological Process | RNA export from nucleus |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameNuclear pore complex protein 14
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ17602
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Nucleus membrane ; Peripheral membrane protein
Note: Cytoplasmic side of the nuclear pore complex (By similarity).
Co-localizes with caspase ced-3 to the perinuclear region in germ cells
Co-localizes with caspase ced-3 to the perinuclear region in germ cells
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000440164 | 1-1390 | Nuclear pore complex protein 14 | |||
Sequence: MSNEDVAEDVSQVTDFHFHTCRKFRLFSSKSDGYSQNEINIRNRVATSSQLGVTFVTVNSNQLSCFHTKSLLGYKITRENMNVEVTDLPIKTIRLHGVVLINDMGVNSDGTVLGVLHTKNNDVSVDVFDIKKICTSSSIEPFKPLCTTRVGTEQINQGSCLEWNPAFPDTFAASSTDRSILVAKINVQSPANQKLVGIGKFGAVTTAISWSPKGKQLTIGDSLGKIVQLKPELEVVRSQHGPENKPNYGRITGLCWLATTEWLVSLENGTDQDAYLMRCKKDKPTEWIQFHELSYSSSKWPLPPQLFPATQLLVDWNVVIVGNSKTSEISTVGKRDDWQTWVPVEGESIYLPTTSSGKDTVPIGVAVDRSMTDEVLLNPDGSQRHRPSPLVLCLTNDGILTAHHIISTFAAHIPCQMSSQNLAINDLKKLQFDSQKPISAPPSDQTPVTKPSTVFGQKPEAETLKSSLVGSPSSVQTPKPSSSLFNPKSIASNIETSQLTESKPSTPAAPSSQPKIASTPKSEAIPKISDKTLEHKKAELIATKKQVLIERMDKINDSMAGAKDATMKLSFAVGKVKTTIMECADVVRASLGDSKEVMDELKNLILSIERMSDRTQHTVKEMDFEIDEKMELVAGVEDGNQVLEKLRNMSETEKLMRFNKLETAADLLNGKYEECSDLIKKLRMSLSEKESLRKQAILSPLRLSSNLNQLRSGSETELALKVMRNVSKIIMDTREQIQRTELEFVRFQRDVKFQNFKKGKENLNFTQPLEMSSLDGDAPQGKSLTDAESIKVRQALVNQIQKRGIVKTRNVIVESYKKSENSAAMKNDLLDTSNLSNAILKLSMTPRRVMPSSSLFSASPSTPSTKSDAATQADEPPIVKTVVVTVESPAKPIASAPAVSSPLIKLNTTTATTTMTTPKVTVPKEEANKTQDQKPIISTPASSSIFSSGSLFGTKTQTPLVSKEESTLTTGVPSLINSSLSISPQEIEKASSKVETLNKTEEVKDEKSENEVTPDLKSEEPKSLETKVKEEPKPAVQTPVKEEETGSNIQKTPSFSFNSTTTPKSTSSTSSIFGGGLKTQTPSSSNSTNIFGARTTTTATPTPASNTSSIFGGGSKAASSPFGSFGQAGCQPAKTSNPATSTASVTFSFNTGATSASAKPAGFGSFGAGASAKPSSVFGGSVTAPTVPNVDDGMEDDSMANGGGSGGFMSGLGNARTSNTSGGNNPFAPKTSTGTSASSSSWLFGGGGNQQQQQQQKPSFSFNTAGSSAQQASAPATGTSSVFGGAPKFGSQPAFGAKPFGGGANAGLSKNASIFGGATSSTTNNPATGGFAQFASGQKTSSLFGGGATPQTNTSIFGGGANTTPAPTSSVFGGGASANANKPTSFTSWR |
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Interacts with caspase ced-3 (via propeptide); the interaction tethers ced-3 to the nuclear membrane and prevents its autoprocessing in absence of ced-4.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 434-530 | Disordered | ||||
Sequence: SQKPISAPPSDQTPVTKPSTVFGQKPEAETLKSSLVGSPSSVQTPKPSSSLFNPKSIASNIETSQLTESKPSTPAAPSSQPKIASTPKSEAIPKISD | ||||||
Compositional bias | 436-453 | Polar residues | ||||
Sequence: KPISAPPSDQTPVTKPST | ||||||
Compositional bias | 464-519 | Polar residues | ||||
Sequence: LKSSLVGSPSSVQTPKPSSSLFNPKSIASNIETSQLTESKPSTPAAPSSQPKIAST | ||||||
Compositional bias | 851-871 | Polar residues | ||||
Sequence: PSSSLFSASPSTPSTKSDAAT | ||||||
Region | 851-874 | Disordered | ||||
Sequence: PSSSLFSASPSTPSTKSDAATQAD | ||||||
Region | 985-1118 | Disordered | ||||
Sequence: QEIEKASSKVETLNKTEEVKDEKSENEVTPDLKSEEPKSLETKVKEEPKPAVQTPVKEEETGSNIQKTPSFSFNSTTTPKSTSSTSSIFGGGLKTQTPSSSNSTNIFGARTTTTATPTPASNTSSIFGGGSKAA | ||||||
Compositional bias | 992-1038 | Basic and acidic residues | ||||
Sequence: SKVETLNKTEEVKDEKSENEVTPDLKSEEPKSLETKVKEEPKPAVQT | ||||||
Compositional bias | 1041-1118 | Polar residues | ||||
Sequence: KEEETGSNIQKTPSFSFNSTTTPKSTSSTSSIFGGGLKTQTPSSSNSTNIFGARTTTTATPTPASNTSSIFGGGSKAA | ||||||
Repeat | 1073-1074 | 1 | ||||
Sequence: FG | ||||||
Region | 1073-1373 | 17 X 2 AA repeats of F-G | ||||
Sequence: FGGGLKTQTPSSSNSTNIFGARTTTTATPTPASNTSSIFGGGSKAASSPFGSFGQAGCQPAKTSNPATSTASVTFSFNTGATSASAKPAGFGSFGAGASAKPSSVFGGSVTAPTVPNVDDGMEDDSMANGGGSGGFMSGLGNARTSNTSGGNNPFAPKTSTGTSASSSSWLFGGGGNQQQQQQQKPSFSFNTAGSSAQQASAPATGTSSVFGGAPKFGSQPAFGAKPFGGGANAGLSKNASIFGGATSSTTNNPATGGFAQFASGQKTSSLFGGGATPQTNTSIFGGGANTTPAPTSSVFG | ||||||
Repeat | 1091-1092 | 2 | ||||
Sequence: FG | ||||||
Repeat | 1111-1112 | 3 | ||||
Sequence: FG | ||||||
Repeat | 1122-1123 | 4 | ||||
Sequence: FG | ||||||
Repeat | 1125-1126 | 5 | ||||
Sequence: FG | ||||||
Repeat | 1163-1164 | 6 | ||||
Sequence: FG | ||||||
Repeat | 1166-1167 | 7 | ||||
Sequence: FG | ||||||
Repeat | 1178-1179 | 8 | ||||
Sequence: FG | ||||||
Region | 1183-1280 | Disordered | ||||
Sequence: TAPTVPNVDDGMEDDSMANGGGSGGFMSGLGNARTSNTSGGNNPFAPKTSTGTSASSSSWLFGGGGNQQQQQQQKPSFSFNTAGSSAQQASAPATGTS | ||||||
Compositional bias | 1211-1280 | Polar residues | ||||
Sequence: GLGNARTSNTSGGNNPFAPKTSTGTSASSSSWLFGGGGNQQQQQQQKPSFSFNTAGSSAQQASAPATGTS | ||||||
Repeat | 1244-1245 | 9 | ||||
Sequence: FG | ||||||
Repeat | 1283-1284 | 10 | ||||
Sequence: FG | ||||||
Repeat | 1289-1290 | 11 | ||||
Sequence: FG | ||||||
Repeat | 1295-1296 | 12 | ||||
Sequence: FG | ||||||
Repeat | 1300-1301 | 13 | ||||
Sequence: FG | ||||||
Repeat | 1315-1316 | 14 | ||||
Sequence: FG | ||||||
Region | 1342-1390 | Disordered | ||||
Sequence: SLFGGGATPQTNTSIFGGGANTTPAPTSSVFGGGASANANKPTSFTSWR | ||||||
Repeat | 1344-1345 | 15 | ||||
Sequence: FG | ||||||
Repeat | 1357-1358 | 16 | ||||
Sequence: FG | ||||||
Repeat | 1372-1373 | 17 | ||||
Sequence: FG |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,390
- Mass (Da)147,968
- Last updated1996-11-01 v1
- Checksum2FD1DB4D3B7E43D3
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 436-453 | Polar residues | ||||
Sequence: KPISAPPSDQTPVTKPST | ||||||
Compositional bias | 464-519 | Polar residues | ||||
Sequence: LKSSLVGSPSSVQTPKPSSSLFNPKSIASNIETSQLTESKPSTPAAPSSQPKIAST | ||||||
Compositional bias | 851-871 | Polar residues | ||||
Sequence: PSSSLFSASPSTPSTKSDAAT | ||||||
Compositional bias | 992-1038 | Basic and acidic residues | ||||
Sequence: SKVETLNKTEEVKDEKSENEVTPDLKSEEPKSLETKVKEEPKPAVQT | ||||||
Compositional bias | 1041-1118 | Polar residues | ||||
Sequence: KEEETGSNIQKTPSFSFNSTTTPKSTSSTSSIFGGGLKTQTPSSSNSTNIFGARTTTTATPTPASNTSSIFGGGSKAA | ||||||
Compositional bias | 1211-1280 | Polar residues | ||||
Sequence: GLGNARTSNTSGGNNPFAPKTSTGTSASSSSWLFGGGGNQQQQQQQKPSFSFNTAGSSAQQASAPATGTS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX284601 EMBL· GenBank· DDBJ | CAA99763.1 EMBL· GenBank· DDBJ | Genomic DNA |