Q17005 · LYSC1_ANOGA

Function

function

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

Catalytic activity

  • Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
    EC:3.2.1.17 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

1140102030405060708090100110120130140
TypeIDPosition(s)Description
Active site52
Active site69

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionlysozyme activity
Biological Processdefense response to bacterium
Biological Processkilling of cells of another organism

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Lysozyme c-1
  • EC number
  • Alternative names
    • 1,4-beta-N-acetylmuramidase

Gene names

    • ORF names
      AGAP007347

Organism names

  • Taxonomic identifier
  • Strains
    • Pinkeye
    • PEST
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles

Accessions

  • Primary accession
    Q17005
  • Secondary accessions
    • Q4ZIL2
    • Q7PF88

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-20
ChainPRO_000001850421-140Lysozyme c-1
Disulfide bond26↔139
Disulfide bond47↔128
Disulfide bond81↔94
Disulfide bond90↔108

Keywords

Proteomic databases

Expression

Tissue specificity

Expressed in salivary glands and Malpighian tubules.

Induction

By bacterial infection, expression significantly increases 6-12 hours post challenge with bacteria.

Developmental stage

Expressed at all developmental stages, highest expression is in the adult.

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain21-140C-type lysozyme

Sequence similarities

Belongs to the glycosyl hydrolase 22 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    140
  • Mass (Da)
    15,338
  • Last updated
    2006-05-16 v2
  • Checksum
    D30D604699316D24
MKVFSTVLLAIVACCAVAEAKTFGKCELAKALANNGIAKASLPDWVCLVQNESAFSTSATNKNKNGSTDYGIFQINNKYWCDSGYGSNDCKIACKNLLNDDITDDIKCAKLIHKRHGFNAWYGWKNHCNGKKLPNVSSCF

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict5in Ref. 1; AAC47326

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U28809
EMBL· GenBank· DDBJ
AAC47326.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ007317
EMBL· GenBank· DDBJ
AAY24699.1
EMBL· GenBank· DDBJ
mRNA
AAAB01008807
EMBL· GenBank· DDBJ
EAA45417.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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