Q16950 · 5HTB1_APLCA
- Protein5-hydroxytryptamine receptor 1
- Gene5HTB1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids453 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
This is one of the several different receptors for 5-hydroxytryptamine (serotonin). 5-HT plays important roles in various behavioral and physiological processes in aplysia. These include feeding, locomotion, circadian rhythm, learning and memory, synaptic plasticity, and synaptic growth. This receptor is mediated by G proteins that stimulate phospholipase C.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | dendrite | |
Cellular Component | plasma membrane | |
Cellular Component | synapse | |
Molecular Function | G protein-coupled serotonin receptor activity | |
Molecular Function | neurotransmitter receptor activity | |
Biological Process | chemical synaptic transmission | |
Biological Process | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended name5-hydroxytryptamine receptor 1
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Gastropoda > Heterobranchia > Euthyneura > Tectipleura > Aplysiida > Aplysioidea > Aplysiidae > Aplysia
Accessions
- Primary accessionQ16950
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-36 | Extracellular | ||||
Sequence: MKSLKSSTHDVPHPEHVVWAPPAYDEQHHLFFSHGT | ||||||
Transmembrane | 37-57 | Helical; Name=1 | ||||
Sequence: VLIGIVGSLIITVAVVGNVLV | ||||||
Topological domain | 58-74 | Cytoplasmic | ||||
Sequence: CLAIFTEPILSHSKSNF | ||||||
Transmembrane | 75-94 | Helical; Name=2 | ||||
Sequence: FIVSLAVADLLLALLVMTFA | ||||||
Topological domain | 95-110 | Extracellular | ||||
Sequence: LVNDMYGYWLFGETFC | ||||||
Transmembrane | 111-133 | Helical; Name=3 | ||||
Sequence: FIWMSADVMCETASIFSICVISY | ||||||
Topological domain | 134-153 | Cytoplasmic | ||||
Sequence: DRLKQVQKPLHYEEFMTTTR | ||||||
Transmembrane | 154-175 | Helical; Name=4 | ||||
Sequence: ALLIIACLWICSFVLSFVPIFL | ||||||
Topological domain | 176-223 | Extracellular | ||||
Sequence: EWHELSVEEIKAIFKDNKTEKEKALEAHNFSSALNQTLGDNQKSNAKH | ||||||
Transmembrane | 224-244 | Helical; Name=5 | ||||
Sequence: VCLFDVHFTYSVIYSFICFYV | ||||||
Topological domain | 245-301 | Cytoplasmic | ||||
Sequence: PCTLMLTNYLRLFLIAQTHQVRIRSLQMTNPPQLRGQGASSYRNQGTQGSKAARTLT | ||||||
Transmembrane | 302-322 | Helical; Name=6 | ||||
Sequence: IITGTFLACWLPFFIINPIAA | ||||||
Topological domain | 323-331 | Extracellular | ||||
Sequence: ADEHLIPLE | ||||||
Transmembrane | 332-352 | Helical; Name=7 | ||||
Sequence: CFMVTIWLGYFNSSVNPIIYG | ||||||
Topological domain | 353-453 | Cytoplasmic | ||||
Sequence: TSNSKFRAAFKRLLRCRSVKSVVGSISPVSPAYRAFSWIRPSRLDLSSSEHPSDACDTGRGKNSKGGDCATADPTKPDVSVSEEIIYAGTKVFDSDTAFSS |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000068983 | 1-453 | 5-hydroxytryptamine receptor 1 | |||
Sequence: MKSLKSSTHDVPHPEHVVWAPPAYDEQHHLFFSHGTVLIGIVGSLIITVAVVGNVLVCLAIFTEPILSHSKSNFFIVSLAVADLLLALLVMTFALVNDMYGYWLFGETFCFIWMSADVMCETASIFSICVISYDRLKQVQKPLHYEEFMTTTRALLIIACLWICSFVLSFVPIFLEWHELSVEEIKAIFKDNKTEKEKALEAHNFSSALNQTLGDNQKSNAKHVCLFDVHFTYSVIYSFICFYVPCTLMLTNYLRLFLIAQTHQVRIRSLQMTNPPQLRGQGASSYRNQGTQGSKAARTLTIITGTFLACWLPFFIINPIAAADEHLIPLECFMVTIWLGYFNSSVNPIIYGTSNSKFRAAFKRLLRCRSVKSVVGSISPVSPAYRAFSWIRPSRLDLSSSEHPSDACDTGRGKNSKGGDCATADPTKPDVSVSEEIIYAGTKVFDSDTAFSS | ||||||
Disulfide bond | 110↔225 | |||||
Sequence: CFIWMSADVMCETASIFSICVISYDRLKQVQKPLHYEEFMTTTRALLIIACLWICSFVLSFVPIFLEWHELSVEEIKAIFKDNKTEKEKALEAHNFSSALNQTLGDNQKSNAKHVC |
Keywords
- PTM
Expression
Tissue specificity
Reproductive system.
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 397-428 | Disordered | ||||
Sequence: DLSSSEHPSDACDTGRGKNSKGGDCATADPTK |
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Keywords
- Domain
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length453
- Mass (Da)50,622
- Last updated1996-11-01 v1
- Checksum227B997840C0C820