Q16602 · CALRL_HUMAN
- ProteinCalcitonin gene-related peptide type 1 receptor
- GeneCALCRL
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids461 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity).
Receptor for adrenomedullin together with RAMP2 (PubMed:22102369, PubMed:30115739).
The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (PubMed:22102369, PubMed:30115739).
Receptor for adrenomedullin together with RAMP2 (PubMed:22102369, PubMed:30115739).
The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (PubMed:22102369, PubMed:30115739).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameCalcitonin gene-related peptide type 1 receptor
- Short namesCGRP type 1 receptor
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ16602
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 23-146 | Extracellular | ||||
Sequence: ELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTI | ||||||
Transmembrane | 147-166 | Helical; Name=1 | ||||
Sequence: IGHGLSIASLLISLGIFFYF | ||||||
Topological domain | 167-173 | Cytoplasmic | ||||
Sequence: KSLSCQR | ||||||
Transmembrane | 174-193 | Helical; Name=2 | ||||
Sequence: ITLHKNLFFSFVCNSVVTII | ||||||
Topological domain | 194-213 | Extracellular | ||||
Sequence: HLTAVANNQALVATNPVSCK | ||||||
Transmembrane | 214-236 | Helical; Name=3 | ||||
Sequence: VSQFIHLYLMGCNYFWMLCEGIY | ||||||
Topological domain | 237-253 | Cytoplasmic | ||||
Sequence: LHTLIVVAVFAEKQHLM | ||||||
Transmembrane | 254-273 | Helical; Name=4 | ||||
Sequence: WYYFLGWGFPLIPACIHAIA | ||||||
Topological domain | 274-289 | Extracellular | ||||
Sequence: RSLYYNDNCWISSDTH | ||||||
Transmembrane | 290-313 | Helical; Name=5 | ||||
Sequence: LLYIIHGPICAALLVNLFFLLNIV | ||||||
Topological domain | 314-336 | Cytoplasmic | ||||
Sequence: RVLITKLKVTHQAESNLYMKAVR | ||||||
Transmembrane | 337-354 | Helical; Name=6 | ||||
Sequence: ATLILVPLLGIEFVLIPW | ||||||
Topological domain | 355-366 | Extracellular | ||||
Sequence: RPEGKIAEEVYD | ||||||
Transmembrane | 367-388 | Helical; Name=7 | ||||
Sequence: YIMHILMHFQGLLVSTIFCFFN | ||||||
Topological domain | 389-461 | Cytoplasmic | ||||
Sequence: GEVQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN |
Keywords
- Cellular component
Disease & Variants
Involvement in disease
Lymphatic malformation 8 (LMPHM8)
- Note
- DescriptionA form of primary lymphedema, a disease characterized by swelling of body parts due to developmental anomalies and functional defects of the lymphatic system. Adult patients with lymphedema may suffer from recurrent local infections. Impaired lymphatic drainage in the fetus can develop into hydrops fetalis, a severe condition characterized by excessive fluid accumulation in more than two fetal extra-vascular compartments and body cavities, placental enlargement and edema, pericardial or pleural effusion, or ascites. LMPHM8 is an autosomal recessive form characterized by onset in utero and fetal death due to non-immune hydrops fetalis.
- See alsoMIM:618773
Natural variants in LMPHM8
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_083775 | 205 | missing | in LMPHM8; uncertain significance; decreased function in adenylate cyclase-modulating G protein-coupled receptor signaling pathway; decreased interaction with RAMP2; decreased protein levels at the cell membrane |
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_054822 | 8 | in dbSNP:rs698577 | |||
Sequence: Y → N | ||||||
Natural variant | VAR_049453 | 16 | in dbSNP:rs13391909 | |||
Sequence: F → L | ||||||
Mutagenesis | 72 | Strongly reduced affinity for adrenomedullin. | ||||
Sequence: W → A | ||||||
Mutagenesis | 92 | Strongly reduced affinity for adrenomedullin. | ||||
Sequence: F → A | ||||||
Mutagenesis | 121 | Strongly reduced affinity for adrenomedullin. | ||||
Sequence: W → A | ||||||
Natural variant | VAR_083775 | 205 | in LMPHM8; uncertain significance; decreased function in adenylate cyclase-modulating G protein-coupled receptor signaling pathway; decreased interaction with RAMP2; decreased protein levels at the cell membrane | |||
Sequence: Missing | ||||||
Natural variant | VAR_049454 | 274 | in dbSNP:rs34010553 | |||
Sequence: R → I |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 574 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Signal | 1-22 | UniProt | |||||
Sequence: MEKKCTLYFLVLLPFFMILVTA | |||||||
Chain | PRO_0000012811 | 23-461 | UniProt | Calcitonin gene-related peptide type 1 receptor | |||
Sequence: ELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN | |||||||
Disulfide bond | 48↔74 | UniProt | |||||
Sequence: CYQKIMQDPIQQAEGVYCNRTWDGWLC | |||||||
Disulfide bond | 65↔105 | UniProt | |||||
Sequence: CNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKIC | |||||||
Glycosylation | 66 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Disulfide bond | 88↔127 | UniProt | |||||
Sequence: CPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQC | |||||||
Glycosylation | 118 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 123 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Modified residue (large scale data) | 409 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 420 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 420 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 445 | UniProt | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Predominantly expressed in the lung and heart.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Heterodimer of CALCRL and RAMP3 (By similarity).
Heterodimer of CALCRL and RAMP1 or CALCRL and RAMP2
Heterodimer of CALCRL and RAMP1 or CALCRL and RAMP2
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q16602 | CALCA P06881 | 5 | EBI-962878, EBI-962928 | |
BINARY | Q16602 | RAMP1 O60894 | 4 | EBI-962878, EBI-962893 | |
BINARY | Q16602 | RAMP2 O60895 | 6 | EBI-962878, EBI-9009040 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length461
- Mass (Da)52,979
- Last updated2022-02-23 v3
- ChecksumDAD6253283088CB4
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 144 | in Ref. 4; BAF84319 | ||||
Sequence: L → Q |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L76380 EMBL· GenBank· DDBJ | AAC41994.1 EMBL· GenBank· DDBJ | mRNA | ||
U17473 EMBL· GenBank· DDBJ | AAA62158.1 EMBL· GenBank· DDBJ | mRNA | ||
AY389506 EMBL· GenBank· DDBJ | AAQ91332.1 EMBL· GenBank· DDBJ | mRNA | ||
AK291630 EMBL· GenBank· DDBJ | BAF84319.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK292998 EMBL· GenBank· DDBJ | BAF85687.1 EMBL· GenBank· DDBJ | mRNA | ||
AC007319 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC074020 EMBL· GenBank· DDBJ | AAY14996.1 EMBL· GenBank· DDBJ | Genomic DNA |