Q16602 · CALRL_HUMAN

  • Protein
    Calcitonin gene-related peptide type 1 receptor
  • Gene
    CALCRL
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity).
Receptor for adrenomedullin together with RAMP2 (PubMed:22102369, PubMed:30115739).
The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (PubMed:22102369, PubMed:30115739).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentadrenomedullin receptor complex
Cellular ComponentCGRP receptor complex
Cellular Componentcytoplasm
Cellular Componentendoplasmic reticulum
Cellular Componentendosome
Cellular Componentlysosome
Cellular Componentplasma membrane
Molecular Functionadrenomedullin binding
Molecular Functionadrenomedullin receptor activity
Molecular Functioncalcitonin gene-related peptide receptor activity
Molecular Functioncalcitonin receptor activity
Molecular FunctionG protein-coupled receptor activity
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Processadrenomedullin receptor signaling pathway
Biological Processangiogenesis
Biological Processcalcitonin gene-related peptide receptor signaling pathway
Biological Processcalcium ion transport
Biological Processcell surface receptor signaling pathway
Biological Processcellular response to sucrose stimulus
Biological ProcessG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Biological Processheart development
Biological Processpositive regulation of vascular associated smooth muscle cell proliferation
Biological Processprotein transport
Biological Processreceptor internalization
Biological Processvascular associated smooth muscle cell proliferation

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Calcitonin gene-related peptide type 1 receptor
  • Short names
    CGRP type 1 receptor
  • Alternative names
    • Calcitonin receptor-like receptor

Gene names

    • Name
      CALCRL
    • Synonyms
      CGRPR

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q16602
  • Secondary accessions
    • A8K6G5
    • A8KAD3
    • Q53S02
    • Q53TS5

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain23-146Extracellular
Transmembrane147-166Helical; Name=1
Topological domain167-173Cytoplasmic
Transmembrane174-193Helical; Name=2
Topological domain194-213Extracellular
Transmembrane214-236Helical; Name=3
Topological domain237-253Cytoplasmic
Transmembrane254-273Helical; Name=4
Topological domain274-289Extracellular
Transmembrane290-313Helical; Name=5
Topological domain314-336Cytoplasmic
Transmembrane337-354Helical; Name=6
Topological domain355-366Extracellular
Transmembrane367-388Helical; Name=7
Topological domain389-461Cytoplasmic

Keywords

Disease & Variants

Involvement in disease

Lymphatic malformation 8 (LMPHM8)

  • Note
    • The disease may be caused by variants affecting the gene represented in this entry
  • Description
    A form of primary lymphedema, a disease characterized by swelling of body parts due to developmental anomalies and functional defects of the lymphatic system. Adult patients with lymphedema may suffer from recurrent local infections. Impaired lymphatic drainage in the fetus can develop into hydrops fetalis, a severe condition characterized by excessive fluid accumulation in more than two fetal extra-vascular compartments and body cavities, placental enlargement and edema, pericardial or pleural effusion, or ascites. LMPHM8 is an autosomal recessive form characterized by onset in utero and fetal death due to non-immune hydrops fetalis.
  • See also
    MIM:618773
Natural variants in LMPHM8
Variant IDPosition(s)ChangeDescription
VAR_083775205missingin LMPHM8; uncertain significance; decreased function in adenylate cyclase-modulating G protein-coupled receptor signaling pathway; decreased interaction with RAMP2; decreased protein levels at the cell membrane

Features

Showing features for natural variant, mutagenesis.

TypeIDPosition(s)Description
Natural variantVAR_0548228in dbSNP:rs698577
Natural variantVAR_04945316in dbSNP:rs13391909
Mutagenesis72Strongly reduced affinity for adrenomedullin.
Mutagenesis92Strongly reduced affinity for adrenomedullin.
Mutagenesis121Strongly reduced affinity for adrenomedullin.
Natural variantVAR_083775205in LMPHM8; uncertain significance; decreased function in adenylate cyclase-modulating G protein-coupled receptor signaling pathway; decreased interaction with RAMP2; decreased protein levels at the cell membrane
Natural variantVAR_049454274in dbSNP:rs34010553

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 574 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation, modified residue (large scale data), modified residue.

TypeIDPosition(s)SourceDescription
Signal1-22UniProt
ChainPRO_000001281123-461UniProt
Disulfide bond48↔74UniProt
Disulfide bond65↔105UniProt
Glycosylation66UniProtN-linked (GlcNAc...) asparagine
Disulfide bond88↔127UniProt
Glycosylation118UniProtN-linked (GlcNAc...) asparagine
Glycosylation123UniProtN-linked (GlcNAc...) asparagine
Modified residue (large scale data)409PRIDEPhosphoserine
Modified residue420UniProtPhosphoserine
Modified residue (large scale data)420PRIDEPhosphoserine
Modified residue445UniProtPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Predominantly expressed in the lung and heart.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Heterodimer of CALCRL and RAMP3 (By similarity).
Heterodimer of CALCRL and RAMP1 or CALCRL and RAMP2

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q16602CALCA P068815EBI-962878, EBI-962928
BINARY Q16602RAMP1 O608944EBI-962878, EBI-962893
BINARY Q16602RAMP2 O608956EBI-962878, EBI-9009040

Protein-protein interaction databases

Chemistry

Miscellaneous

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    461
  • Mass (Da)
    52,979
  • Last updated
    2022-02-23 v3
  • Checksum
    DAD6253283088CB4
MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
B8ZZJ4B8ZZJ4_HUMANCALCRL37
E7EN01E7EN01_HUMANCALCRL77

Sequence caution

The sequence BAF84319.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict144in Ref. 4; BAF84319

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L76380
EMBL· GenBank· DDBJ
AAC41994.1
EMBL· GenBank· DDBJ
mRNA
U17473
EMBL· GenBank· DDBJ
AAA62158.1
EMBL· GenBank· DDBJ
mRNA
AY389506
EMBL· GenBank· DDBJ
AAQ91332.1
EMBL· GenBank· DDBJ
mRNA
AK291630
EMBL· GenBank· DDBJ
BAF84319.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK292998
EMBL· GenBank· DDBJ
BAF85687.1
EMBL· GenBank· DDBJ
mRNA
AC007319
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC074020
EMBL· GenBank· DDBJ
AAY14996.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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