Q16538 · GP162_HUMAN

  • Protein
    Probable G-protein coupled receptor 162
  • Gene
    GPR162
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Orphan receptor.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular FunctionG protein-coupled receptor activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable G-protein coupled receptor 162
  • Alternative names
    • Gene-rich cluster gene A protein

Gene names

    • Name
      GPR162
    • Synonyms
      GRCA

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q16538
  • Secondary accessions
    • Q16664
    • Q59EH5
    • Q66K56

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-17Extracellular
Transmembrane18-38Helical; Name=1
Topological domain39-49Cytoplasmic
Transmembrane50-70Helical; Name=2
Topological domain71-91Extracellular
Transmembrane92-112Helical; Name=3
Topological domain113-133Cytoplasmic
Transmembrane134-154Helical; Name=4
Topological domain155-174Extracellular
Transmembrane175-195Helical; Name=5
Topological domain196-275Cytoplasmic
Transmembrane276-296Helical; Name=6
Topological domain297-303Extracellular
Transmembrane304-324Helical; Name=7
Topological domain325-588Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_049407459in dbSNP:rs11612427

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 700 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain, glycosylation, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00000696471-588UniProtProbable G-protein coupled receptor 162
Glycosylation86UniProtN-linked (GlcNAc...) asparagine
Modified residue413UniProtPhosphoserine
Modified residue435UniProtPhosphoserine
Modified residue (large scale data)524PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q16538UBQLN1 Q9UMX03EBI-22387200, EBI-741480
BINARY Q16538UBQLN2 Q9UHD93EBI-22387200, EBI-947187

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region445-474Disordered
Region511-550Disordered

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q16538-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    A-2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    588
  • Mass (Da)
    63,930
  • Last updated
    1996-11-01 v1
  • Checksum
    746BBE0BD83C8566
MARGGAGAEEASLRSNALSWLACGLLALLANAWIILSISAKQQKHKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRQASSDYDWNESICKVFVSTYYTLALATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNNGERYYARGCQFIVSKIGLGFGVCFSLLLLGGIVMGLVCVAITFYQTLWARPRRARQARRVGGGGGTKAGGPGALGTRPAFEVPAIVVEDARGKRRSSLDGSESAKTSLQVTNLVSAIVFLYDSLTGVPILVVSFFSLKSDSAPPWMVLAVLWCSMAQTLLLPSFIWSCERYRADVRTVWEQCVAIMSEEDGDDDGGCDDYAEGRVCKVRFDANGATGPGSRDPAQVKLLPGRHMLFPPLERVHYLQVPLSRRLSHDETNIFSTPREPGSFLHKWSSSDDIRVLPAQSRALGGPPEYLGQRHRLEDEEDEEEAEGGGLASLRQFLESGVLGSGGGPPRGPGFFREEITTFIDETPLPSPTASPGHSPRRPRPLGLSPRRLSLGSPESRAVGLPLGLSAGRRCSLTGGEESARAWGGSWGPGNPIFPQLTL

Q16538-2

  • Name
    2
  • Synonyms
    A-1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
J3KPJ9J3KPJ9_HUMANGPR162284
U3KQI6U3KQI6_HUMANGPR162228

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0163021-284in isoform 2
Alternative sequenceVSP_016303285-289in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U47924
EMBL· GenBank· DDBJ
AAB51310.1
EMBL· GenBank· DDBJ
Genomic DNA
U47924
EMBL· GenBank· DDBJ
AAB51311.1
EMBL· GenBank· DDBJ
Genomic DNA
U47925
EMBL· GenBank· DDBJ
AAC50463.1
EMBL· GenBank· DDBJ
mRNA
U47928
EMBL· GenBank· DDBJ
AAC50466.1
EMBL· GenBank· DDBJ
mRNA
BC002353
EMBL· GenBank· DDBJ
AAH02353.1
EMBL· GenBank· DDBJ
mRNA
BC080585
EMBL· GenBank· DDBJ
AAH80585.1
EMBL· GenBank· DDBJ
mRNA
AB209836
EMBL· GenBank· DDBJ
BAD93073.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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