Q16534 · HLF_HUMAN
- ProteinHepatic leukemia factor
- GeneHLF
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids295 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Cellular Component | RNA polymerase II transcription regulator complex | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | double-stranded DNA binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | sequence-specific DNA binding | |
Molecular Function | sequence-specific double-stranded DNA binding | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | regulation of transcription by RNA polymerase II | |
Biological Process | rhythmic process | |
Biological Process | skeletal muscle cell differentiation |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHepatic leukemia factor
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ16534
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Involvement in disease
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_008515 | 253 | in fusion protein; decreases DNA-binding activity | |||
Sequence: I → F |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 302 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000076510 | 1-295 | Hepatic leukemia factor | |||
Sequence: MEKMSRPLPLNPTFIPPPYGVLRSLLENPLKLPLHHEDAFSKDKDKEKKLDDESNSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL |
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in liver; lower levels in lung and kidney.
Induction
Accumulates according to a robust circadian rhythm.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Binds DNA specifically as homodimer or heterodimer with other PAR factors.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q16534 | BATF Q16520 | 2 | EBI-2798854, EBI-749503 | |
BINARY | Q16534 | BATF3 Q9NR55 | 2 | EBI-2798854, EBI-10312707 | |
BINARY | Q16534 | DBP Q10586 | 3 | EBI-2798854, EBI-3908088 | |
BINARY | Q16534 | DDIT3 P35638 | 3 | EBI-2798854, EBI-742651 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 37-54 | Basic and acidic residues | ||||
Sequence: EDAFSKDKDKEKKLDDES | ||||||
Region | 37-70 | Disordered | ||||
Sequence: EDAFSKDKDKEKKLDDESNSPTVPQSAFLGPTLW | ||||||
Region | 93-167 | Disordered | ||||
Sequence: SENGIPPSPSQHDHSPHPPGLQPASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPD | ||||||
Compositional bias | 152-166 | Polar residues | ||||
Sequence: QLLPANRNTPSPIDP | ||||||
Domain | 225-288 | bZIP | ||||
Sequence: DDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKY | ||||||
Region | 227-247 | Basic motif | ||||
Sequence: KYWARRRKNNMAAKRSRDARR | ||||||
Region | 248-255 | Leucine-zipper | ||||
Sequence: LKENQIAI |
Sequence similarities
Belongs to the bZIP family. PAR subfamily.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q16534-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length295
- Mass (Da)33,199
- Last updated1996-11-01 v1
- Checksum80572A727BBB5635
Q16534-2
- Name2
- Differences from canonical
- 1-85: Missing
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_053852 | 1-85 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 37-54 | Basic and acidic residues | ||||
Sequence: EDAFSKDKDKEKKLDDES | ||||||
Compositional bias | 152-166 | Polar residues | ||||
Sequence: QLLPANRNTPSPIDP |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M95585 EMBL· GenBank· DDBJ | AAA52675.1 EMBL· GenBank· DDBJ | mRNA | ||
M95586 EMBL· GenBank· DDBJ | AAA58445.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
X68985 EMBL· GenBank· DDBJ | CAA48777.1 EMBL· GenBank· DDBJ | mRNA | ||
AK290043 EMBL· GenBank· DDBJ | BAF82732.1 EMBL· GenBank· DDBJ | mRNA | ||
AK315079 EMBL· GenBank· DDBJ | BAG37547.1 EMBL· GenBank· DDBJ | mRNA | ||
CR541672 EMBL· GenBank· DDBJ | CAG46473.1 EMBL· GenBank· DDBJ | mRNA | ||
AC007638 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471109 EMBL· GenBank· DDBJ | EAW94544.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC036093 EMBL· GenBank· DDBJ | AAH36093.1 EMBL· GenBank· DDBJ | mRNA |