Q16425 · Q16425_HUMAN
- ProteinAngiotensin-converting enzyme
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids135 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Soluble form that is released in blood plasma and other body fluids following proteolytic cleavage in the juxtamembrane stalk region.
Catalytic activity
- H2O + Leu-enkephalin = L-phenylalanyl-L-leucine + L-tyrosylglycylglycineThis reaction proceeds in the forward direction.
- H2O + Met-enkephalin = L-phenylalanyl-L-methionine + L-tyrosylglycylglycineThis reaction proceeds in the forward direction.
- H2O + Met-enkephalin-Arg-Phe = L-arginyl-L-phenylalanine + Met-enkephalinThis reaction proceeds in the forward direction.
- H2O + neurotensin = L-isoleucyl-L-leucine + neurotensin(1-11)This reaction proceeds in the forward direction.
- H2O + substance P = Gly-L-Leu-L-Met-NH2 + substance P(1-8)This reaction proceeds in the forward direction.
- H2O + substance P = L-Leu-L-Met-NH2 + substance P(1-9)This reaction proceeds in the forward direction.
- H2O + substance P = L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6)This reaction proceeds in the forward direction.
- bradykinin + H2O = bradykinin(1-7) + L-Phe-L-ArgThis reaction proceeds in the forward direction.
- goralatide + H2O = L-lysyl-L-proline + N-acetyl-L-seryl-L-aspartateThis reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 zinc ion per subunit.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | extracellular region | |
Cellular Component | plasma membrane | |
Molecular Function | carboxypeptidase activity | |
Molecular Function | metal ion binding | |
Molecular Function | metallopeptidase activity | |
Molecular Function | peptidyl-dipeptidase activity | |
Biological Process | positive regulation of systemic arterial blood pressure | |
Biological Process | proteolysis | |
Biological Process | regulation of systemic arterial blood pressure by renin-angiotensin |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameAngiotensin-converting enzyme
- EC number
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ16425
PTM/Processing
Features
Showing features for glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Glycosylation | 3 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
Structure
Sequence
- Sequence statusFragment
- Length135
- Mass (Da)15,688
- Last updated1996-11-01 v1
- Checksum015F923A0C756C34
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 135 | |||||
Sequence: D |