Q16425 · Q16425_HUMAN

  • Protein
    Angiotensin-converting enzyme
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Soluble form that is released in blood plasma and other body fluids following proteolytic cleavage in the juxtamembrane stalk region.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • H2O + Leu-enkephalin = L-phenylalanyl-L-leucine + L-tyrosylglycylglycine
    This reaction proceeds in the forward direction.
  • H2O + Met-enkephalin = L-phenylalanyl-L-methionine + L-tyrosylglycylglycine
    This reaction proceeds in the forward direction.
  • H2O + Met-enkephalin-Arg-Phe = L-arginyl-L-phenylalanine + Met-enkephalin
    This reaction proceeds in the forward direction.
  • H2O + neurotensin = L-isoleucyl-L-leucine + neurotensin(1-11)
    This reaction proceeds in the forward direction.
  • H2O + substance P = Gly-L-Leu-L-Met-NH2 + substance P(1-8)
    This reaction proceeds in the forward direction.
  • H2O + substance P = L-Leu-L-Met-NH2 + substance P(1-9)
    This reaction proceeds in the forward direction.
  • H2O + substance P = L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6)
    This reaction proceeds in the forward direction.
  • Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.
    EC:3.4.15.1 (UniProtKB | ENZYME | Rhea)
  • angiotensin I + H2O = angiotensin II + L-histidyl-L-leucine
    This reaction proceeds in the forward direction.
    EC:3.4.15.1 (UniProtKB | ENZYME | Rhea)
  • bradykinin + H2O = bradykinin(1-7) + L-Phe-L-Arg
    This reaction proceeds in the forward direction.
  • goralatide + H2O = L-lysyl-L-proline + N-acetyl-L-seryl-L-aspartate
    This reaction proceeds in the forward direction.

Cofactor

Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.
chloride (UniProtKB | Rhea| CHEBI:17996 )

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentextracellular region
Cellular Componentplasma membrane
Molecular Functioncarboxypeptidase activity
Molecular Functionmetal ion binding
Molecular Functionmetallopeptidase activity
Molecular Functionpeptidyl-dipeptidase activity
Biological Processpositive regulation of systemic arterial blood pressure
Biological Processproteolysis
Biological Processregulation of systemic arterial blood pressure by renin-angiotensin

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Angiotensin-converting enzyme
  • EC number

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q16425

Subcellular Location

Cytoplasm
Membrane
; Single-pass type I membrane protein
Secreted

PTM/Processing

Features

Showing features for glycosylation.

TypeIDPosition(s)Description
Glycosylation3N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

Family & Domains

Sequence similarities

Belongs to the peptidase M2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    135
  • Mass (Da)
    15,688
  • Last updated
    1996-11-01 v1
  • Checksum
    015F923A0C756C34
GSNKTATCWSLDPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWVD

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue135

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
S81361
EMBL· GenBank· DDBJ
AAD14360.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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