Q15ES5 · Q15ES5_SCHMA

Function

function

Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Lipid metabolism; fatty acid biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionvery-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity
Biological Processfatty acid elongation
Biological Processsphingolipid biosynthetic process
Biological Processvery long-chain fatty acid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
  • EC number

Organism names

  • Taxonomic identifier
  • Strain
    • Puerto Rican
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Platyhelminthes > Trematoda > Digenea > Strigeidida > Schistosomatoidea > Schistosomatidae > Schistosoma

Accessions

  • Primary accession
    Q15ES5

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-28Helical
Transmembrane48-66Helical
Transmembrane133-158Helical
Transmembrane178-195Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the very long-chain fatty acids dehydratase HACD family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    215
  • Mass (Da)
    24,820
  • Last updated
    2006-07-25 v1
  • Checksum
    0546F6FD94AD5F3C
MSIKKSYLGIYNGFQLMGWGYILSLYILESSFKRKWFELSVQVDIFLRLFQSLAVVEIIHSAVGLVRSSVMTTMLQVSSRLLVVWGILYMVPEVARDNLGVPLIVISWSIAEMIRYSYYVADICRVKLNLLTWLRYSGFMILYPTGISGEVLLIVSGIKRLRETEQYSFDLPNALNCSLSYWFAFAAILITYIPGSKTMYTHMMRQRKKVLQNCN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ480551
EMBL· GenBank· DDBJ
ABG21826.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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