Kindlin-2 interacts with beta-catenin and YB-1 to enhance EGFR transcription during glioma progression.
- AnnotationKindlin-2 is up-regulated in glioma cells and acts as an oncogene. It is an independent risk factor for poor prognosis. The Kindlin-2/YB-1/beta-catenin complex promotes EGFR transcription and contributes to glioma progression. Kindlin-2 is a potential diagnostic and prognostic marker in glioma and inhibition of Kindlin-2 may be a novel strategy for glioma treatment.
- CategoryInteraction
- SourceGeneRif: 4904