Q15849 · UT2_HUMAN
- ProteinUrea transporter 2
- GeneSLC14A2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids920 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Isoform 1
Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism.
Isoform 2
Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism.
Catalytic activity
Activity regulation
Isoform 2
Inhibited by phloretin.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | cell adhesion molecule binding | |
Molecular Function | urea transmembrane transporter activity | |
Biological Process | transmembrane transport | |
Biological Process | urea transmembrane transport | |
Biological Process | urea transport |
Keywords
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameUrea transporter 2
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ15849
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Isoform 1
Apical cell membrane ; Multi-pass membrane protein
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 151-170 | Helical | ||||
Sequence: WWTITGGLGTVVSTLTALAL | ||||||
Transmembrane | 176-196 | Helical | ||||
Sequence: AIASGLHGYNGMLVGLLMAVF | ||||||
Transmembrane | 204-224 | Helical | ||||
Sequence: WWLLFPVTFTAMSCPVLSSAL | ||||||
Transmembrane | 233-253 | Helical | ||||
Sequence: LPVFTLPFNIAVTLYLAATGH | ||||||
Transmembrane | 272-291 | Helical | ||||
Sequence: ITWTEMEMPLLLQAIPVGVG | ||||||
Transmembrane | 302-322 | Helical | ||||
Sequence: GGVFLVALFISSPLICLHAAI | ||||||
Transmembrane | 346-366 | Helical | ||||
Sequence: WSYNCVLSCIAIGGMFYALTW | ||||||
Transmembrane | 370-390 | Helical | ||||
Sequence: LLALICALFCAYMEAAISNIM | ||||||
Transmembrane | 392-412 | Helical | ||||
Sequence: VVGVPPGTWAFCLATIIFLLL | ||||||
Transmembrane | 600-620 | Helical | ||||
Sequence: GILIILGLFIQNPWWAISGCL | ||||||
Transmembrane | 638-658 | Helical | ||||
Sequence: AIAAGFHGYNGVLVGLLMAVF | ||||||
Transmembrane | 666-686 | Helical | ||||
Sequence: WWLLLPVIIMSMSCPILSSAL | ||||||
Transmembrane | 695-715 | Helical | ||||
Sequence: LPVFTLPFNITVTLYLAATGH | ||||||
Transmembrane | 764-784 | Helical | ||||
Sequence: GGIFLIALFISSPLICLHAAI | ||||||
Transmembrane | 803-823 | Helical | ||||
Sequence: IYFGLCGFNSTLACIAIGGMF | ||||||
Transmembrane | 832-852 | Helical | ||||
Sequence: LLAIACALFAAYLGAALANML | ||||||
Transmembrane | 854-874 | Helical | ||||
Sequence: VFGLPPCTWPFCLSALTFLLL |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_057016 | 37 | in dbSNP:rs34461862 | |||
Sequence: T → I | ||||||
Natural variant | VAR_060255 | 132 | in dbSNP:rs1484873 | |||
Sequence: I → V | ||||||
Natural variant | VAR_057017 | 443 | in dbSNP:rs35245152 | |||
Sequence: G → S | ||||||
Natural variant | VAR_060256 | 510 | in dbSNP:rs9960464 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_057018 | 750 | in dbSNP:rs1123617 | |||
Sequence: V → I | ||||||
Natural variant | VAR_038690 | 880 | in dbSNP:rs3745009 | |||
Sequence: A → T |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,305 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000065739 | 1-920 | Urea transporter 2 | |||
Sequence: MSDPHSSPLLPEPLSSRYKLYEAEFTSPSWPSTSPDTHPALPLLEMPEEKDLRSSNEDSHIVKIEKLNERSKRKDDGVAHRDSAGQRCICLSKAVGYLTGDMKEYRIWLKDKHLALQFIDWVLRGTAQVMFINNPLSGLIIFIGLLIQNPWWTITGGLGTVVSTLTALALGQDRSAIASGLHGYNGMLVGLLMAVFSEKLDYYWWLLFPVTFTAMSCPVLSSALNSIFSKWDLPVFTLPFNIAVTLYLAATGHYNLFFPTTLVEPVSSVPNITWTEMEMPLLLQAIPVGVGQVYGCDNPWTGGVFLVALFISSPLICLHAAIGSIVGLLAALSVATPFETIYTGLWSYNCVLSCIAIGGMFYALTWQTHLLALICALFCAYMEAAISNIMSVVGVPPGTWAFCLATIIFLLLTTNNPAIFRLPLSKVTYPEANRIYYLTVKSGEEEKAPSGGGGEHPPTAGPKVEEGSEAVLSKHRSVFHIEWSSIRRRSKVFGKGEHQERQNKDPFPYRYRKPTVELLDLDTMEESSEIKVETNISKTSWIRSSMAASGKRVSKALSYITGEMKECGEGLKDKSPVFQFFDWVLRGTSQVMFVNNPLSGILIILGLFIQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGFHGYNGVLVGLLMAVFSDKGDYYWWLLLPVIIMSMSCPILSSALGTIFSKWDLPVFTLPFNITVTLYLAATGHYNLFFPTTLLQPASAMPNITWSEVQVPLLLRAIPVGIGQVYGCDNPWTGGIFLIALFISSPLICLHAAIGSTMGMLAALTIATPFDSIYFGLCGFNSTLACIAIGGMFYVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTTNNPAIYKLPLSKVTYPEANRIYYLSQERNRRASIITKYQAYDVS | ||||||
Modified residue | 477 | Phosphoserine | ||||
Sequence: S | ||||||
Glycosylation | 733 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Isoform 1
Interacts with SNAPIN which enhances its urea transport activity.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q15849 | C4orf3 Q8WVX3-2 | 3 | EBI-1573290, EBI-12003442 | |
BINARY | Q15849 | CMTM7 Q96FZ5 | 3 | EBI-1573290, EBI-2807956 | |
BINARY | Q15849 | EHHADH Q08426 | 3 | EBI-1573290, EBI-2339219 | |
BINARY | Q15849 | LAT O43561-2 | 3 | EBI-1573290, EBI-8070286 | |
BINARY | Q15849 | LRP10 Q7Z4F1 | 3 | EBI-1573290, EBI-2830349 | |
BINARY | Q15849 | PLN P26678 | 3 | EBI-1573290, EBI-692836 | |
BINARY | Q15849 | PLP2 Q04941 | 3 | EBI-1573290, EBI-608347 | |
BINARY | Q15849 | SEC22A Q96IW7 | 3 | EBI-1573290, EBI-8652744 | |
BINARY | Q15849 | TMEM97 Q5BJF2 | 4 | EBI-1573290, EBI-12111910 | |
BINARY | Q15849 | TNF P01375 | 3 | EBI-1573290, EBI-359977 | |
BINARY | Q15849 | TUSC5 A5PKU2 | 3 | EBI-1573290, EBI-11988865 | |
BINARY | Q15849 | VAMP5 O95183 | 3 | EBI-1573290, EBI-10191195 | |
BINARY | Q15849-1 | SNAPIN O95295 | 5 | EBI-1633392, EBI-296723 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 25-57 | Disordered | ||||
Sequence: FTSPSWPSTSPDTHPALPLLEMPEEKDLRSSNE | ||||||
Compositional bias | 43-57 | Basic and acidic residues | ||||
Sequence: LLEMPEEKDLRSSNE | ||||||
Region | 446-467 | Disordered | ||||
Sequence: EKAPSGGGGEHPPTAGPKVEEG |
Sequence similarities
Belongs to the urea transporter family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q15849-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsUT-A1
- Length920
- Mass (Da)101,209
- Last updated2010-03-23 v3
- Checksum23BF379DC0767619
Q15849-2
- Name2
- SynonymsUT-A2
- Differences from canonical
- 1-523: Missing
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
E7EPU1 | E7EPU1_HUMAN | SLC14A2 | 235 |
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_031171 | 1-523 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 43-57 | Basic and acidic residues | ||||
Sequence: LLEMPEEKDLRSSNE | ||||||
Sequence conflict | 195 | in Ref. 2; AAL08485 | ||||
Sequence: V → A | ||||||
Sequence conflict | 515 | in Ref. 3; BAF85111 | ||||
Sequence: T → I | ||||||
Sequence conflict | 723 | in Ref. 2; AAL08485 | ||||
Sequence: T → A | ||||||
Sequence conflict | 905 | in Ref. 3; BAF85111 | ||||
Sequence: N → D |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X96969 EMBL· GenBank· DDBJ | CAA65657.1 EMBL· GenBank· DDBJ | mRNA | ||
AF349446 EMBL· GenBank· DDBJ | AAL08485.1 EMBL· GenBank· DDBJ | mRNA | ||
AK292422 EMBL· GenBank· DDBJ | BAF85111.1 EMBL· GenBank· DDBJ | mRNA | ||
AC023421 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC110446 EMBL· GenBank· DDBJ | AAI10447.1 EMBL· GenBank· DDBJ | mRNA |