Q15631 · TSN_HUMAN
- ProteinTranslin
- GeneTSN
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids228 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | endoribonuclease complex | |
Cellular Component | male germ cell nucleus | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | endonuclease activity | |
Molecular Function | identical protein binding | |
Molecular Function | mRNA binding | |
Molecular Function | RNA binding | |
Molecular Function | sequence-specific DNA binding | |
Molecular Function | single-stranded DNA binding | |
Biological Process | DNA recombination | |
Biological Process | regulatory ncRNA-mediated post-transcriptional gene silencing | |
Biological Process | siRNA processing |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTranslin
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ15631
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 143 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000191683 | 1-228 | UniProt | Translin | |||
Sequence: MSVSEIFVELQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGAGFQDIPKRCLKAREHFGTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIEPDREKGFHLDVEDYLSGVLILASELSRLSVNSVTAGDYSRPLHISTFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRGFNKETAAACVEK | |||||||
Modified residue | 187 | UniProt | N6-acetyllysine | ||||
Sequence: K | |||||||
Modified residue | 190 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 190 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 199 | UniProt | N6-acetyllysine | ||||
Sequence: K |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q15631 | DVL3 Q92997 | 3 | EBI-1044160, EBI-739789 | |
BINARY | Q15631 | GIT2 Q14161 | 2 | EBI-1044160, EBI-1046878 | |
BINARY | Q15631 | GORASP2 Q9H8Y8 | 6 | EBI-1044160, EBI-739467 | |
BINARY | Q15631 | LNX1 Q8TBB1 | 3 | EBI-1044160, EBI-739832 | |
BINARY | Q15631 | MORF4L2 Q15014 | 3 | EBI-1044160, EBI-399257 | |
BINARY | Q15631 | NTAQ1 Q96HA8 | 3 | EBI-1044160, EBI-741158 | |
BINARY | Q15631 | PICK1 Q9NRD5 | 3 | EBI-1044160, EBI-79165 | |
BINARY | Q15631 | SDCBP O00560 | 3 | EBI-1044160, EBI-727004 | |
BINARY | Q15631 | TSN Q15631 | 4 | EBI-1044160, EBI-1044160 | |
BINARY | Q15631 | TSNAX Q99598 | 16 | EBI-1044160, EBI-21353855 | |
BINARY | Q15631 | UBE2I Q7KZS0 | 3 | EBI-1044160, EBI-10180829 | |
BINARY | Q15631 | UBE2K P61086 | 3 | EBI-1044160, EBI-473850 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 86-90 | DNA/RNA binding | ||||
Sequence: RFHEH | ||||||
Region | 177-198 | Leucine-zipper | ||||
Sequence: LDSGFRLLNLKNDSLRKRYDGL |
Sequence similarities
Belongs to the translin family.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q15631-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length228
- Mass (Da)26,183
- Last updated1996-11-01 v1
- Checksum3CAAF20BED7C4939
Q15631-2
- Name2
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0J9YVW2 | A0A0J9YVW2_HUMAN | TSN | 92 | ||
A0A0J9YX41 | A0A0J9YX41_HUMAN | TSN | 36 | ||
H7C1D4 | H7C1D4_HUMAN | TSN | 185 | ||
E9PGT1 | E9PGT1_HUMAN | TSN | 223 |
Features
Showing features for alternative sequence.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X78627 EMBL· GenBank· DDBJ | CAA55341.1 EMBL· GenBank· DDBJ | mRNA | ||
BT019490 EMBL· GenBank· DDBJ | AAV38297.1 EMBL· GenBank· DDBJ | mRNA | ||
BT019491 EMBL· GenBank· DDBJ | AAV38298.1 EMBL· GenBank· DDBJ | mRNA | ||
AK296469 EMBL· GenBank· DDBJ | BAH12364.1 EMBL· GenBank· DDBJ | mRNA | ||
AC018737 EMBL· GenBank· DDBJ | AAY14831.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC002359 EMBL· GenBank· DDBJ | AAH02359.1 EMBL· GenBank· DDBJ | mRNA | ||
Y12563 EMBL· GenBank· DDBJ | CAA73150.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y12564 EMBL· GenBank· DDBJ | CAA73150.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y12565 EMBL· GenBank· DDBJ | CAA73150.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y12566 EMBL· GenBank· DDBJ | CAA73150.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y12567 EMBL· GenBank· DDBJ | CAA73150.1 EMBL· GenBank· DDBJ | Genomic DNA |