The role of c-FLIP in modulation of CD95-induced apoptosis.Scaffidi C., Schmitz I., Krammer P.H., Peter M.E.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-66376PubMedEurope PMCJ. Biol. Chem. 274:1541-1548 (1999)Cited in1Mapped to10
The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex.Shu H.B., Takeuchi M., Goeddel D.V.View abstractCategoriesInteractionSourceIntAct: Q15628PubMedEurope PMCProc Natl Acad Sci U S A 93:13973-13978 (1996)Mapped to4
Systematic mutational analysis of the death domain of the tumor necrosis factor receptor 1-associated protein TRADD.Park A., Baichwal V.R.View abstractCategoriesInteractionSourceIntAct: Q15628PubMedEurope PMCJ Biol Chem 271:9858-9862 (1996)Mapped to2
TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways.Hsu H., Shu H.-B., Pan M.G., Goeddel D.V.View abstractCategoriesInteractionSourceIntAct: Q15628PubMedEurope PMCCell 84:299-308 (1996)Cited in2Mapped to14
OTUD1 deubiquitinase regulates NF-kappaB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways.Oikawa D., Gi M., Kosako H., Shimizu K., Takahashi H., Shiota M., Hosomi S., Komakura K., Wanibuchi H.[...], Tokunaga F.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-66376PubMedEurope PMCCell Death Dis 13:694-694 (2022)Mapped to20
The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-kappaB signaling.Wu B., Qiang L., Zhang Y., Fu Y., Zhao M., Lei Z., Lu Z., Wei Y.G., Dai H.[...], Zhang L.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-66376PubMedEurope PMCCell Mol Immunol 19:276-289 (2022)Mapped to21
Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death.Taft J., Markson M., Legarda D., Patel R., Chan M., Malle L., Richardson A., Gruber C., Martin-Fernandez M.[...], Bogunovic D.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-66376PubMedEurope PMCCell 184:4447-4463.e20 (2021)Mapped to26
Structural basis of NF-kappaB signaling by the p75 neurotrophin receptor interaction with adaptor protein TRADD through their respective death domains.Zhang N., Kisiswa L., Ramanujan A., Li Z., Sim E.W., Tian X., Yuan W., Ibanez C.F., Lin Z.View abstractCategoriesStructureSourcePDB: 7CSQPubMedEurope PMCJ Biol Chem 297:100916-100916 (2021)Mapped to6
Linear Ubiquitination of RIPK1 on Lys612 Regulates Systemic Inflammation via Preventing Cell Death.Tu H., Tang Y., Zhang J., Cheng L., Joo D., Zhao X., Lin X.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-66376PubMedEurope PMCJ Immunol 207:602-612 (2021)Mapped to20
The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death.Wu W., Wang X., Berleth N., Deitersen J., Wallot-Hieke N., Bohler P., Schlutermann D., Stuhldreier F., Cox J.[...], Stork B.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-66376PubMedEurope PMCCell Rep 31:107547-107547 (2020)Mapped to5
Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis.Newton K., Wickliffe K.E., Dugger D.L., Maltzman A., Roose-Girma M., Dohse M., Komuves L., Webster J.D., Dixit V.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-66376PubMedEurope PMCNature 574:428-431 (2019)Cited in3Mapped to42
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation.Dondelinger Y., Delanghe T., Priem D., Wynosky-Dolfi M.A., Sorobetea D., Rojas-Rivera D., Giansanti P., Roelandt R., Gropengiesser J.[...], Bertrand M.J.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-66376PubMedEurope PMCNat. Commun. 10:1729-1729 (2019)Cited in4Mapped to33
TBK1 and IKKepsilon prevent TNF-induced cell death by RIPK1 phosphorylation.Lafont E., Draber P., Rieser E., Reichert M., Kupka S., de Miguel D., Draberova H., von Massenhausen A., Bhamra A.[...], Walczak H.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-66376PubMedEurope PMCNat Cell Biol 20:1389-1399 (2018)Mapped to56
TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging.Xu D., Jin T., Zhu H., Chen H., Ofengeim D., Zou C., Mifflin L., Pan L., Amin P.[...], Yuan J.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-66376PubMedEurope PMCCell 174:1477-1491.e19 (2018)Mapped to99+
The structure of the necrosome RIPK1-RIPK3 core, a human hetero-amyloid signaling complex.Mompean M., Li W., Li J., Laage S., Siemer A.B., Bozkurt G., Wu H., McDermott A.E.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-66376PubMedEurope PMCCell 173:1244-1253 (2018)Cited in2Mapped to15
Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential.Feltham R., Jamal K., Tenev T., Liccardi G., Jaco I., Domingues C.M., Morris O., John S.W., Annibaldi A.[...], Meier P.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-66376PubMedEurope PMCCell Rep 23:470-484 (2018)Mapped to12
p38pisup>MAPKpi/sup>/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection.Menon M.B., Gropengiesser J., Fischer J., Novikova L., Deuretzbacher A., Lafera J., Schimmeck H., Czymmeck N., Ronkina N.[...], Ruckdeschel K.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-66376PubMedEurope PMCNat Cell Biol 19:1248-1259 (2017)Mapped to29
MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death.Dondelinger Y., Delanghe T., Rojas-Rivera D., Priem D., Delvaeye T., Bruggeman I., Van Herreweghe F., Vandenabeele P., Bertrand M.J.M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-66376PubMedEurope PMCNat Cell Biol 19:1237-1247 (2017)Mapped to11
Structure of the C-terminal domain of TRADD reveals a novel fold in the death domain superfamily.Zhang N., Yuan W., Fan J.S., Lin Z.View abstractCategoriesStructureSourcePDB: 5XMEPubMedEurope PMCSci Rep 7:7073-7073 (2017)Mapped to1
MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.Jaco I., Annibaldi A., Lalaoui N., Wilson R., Tenev T., Laurien L., Kim C., Jamal K., Wicky John S.[...], Meier P.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-66376PubMedEurope PMCMol Cell 66:698-710.e5 (2017)Mapped to18
SPATA2 links CYLD to LUBAC, activates CYLD, and controls LUBAC signaling.Elliott P.R., Leske D., Hrdinka M., Bagola K., Fiil B.K., McLaughlin S.H., Wagstaff J., Volkmar N., Christianson J.C.[...], Gyrd-Hansen M.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-66376PubMedEurope PMCMol. Cell 63:990-1005 (2016)Cited in3Mapped to21
Linear ubiquitination is involved in the pathogenesis of optineurin- associated amyotrophic lateral sclerosis.Nakazawa S., Oikawa D., Ishii R., Ayaki T., Takahashi H., Takeda H., Ishitani R., Kamei K., Takeyoshi I.[...], Tokunaga F.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-66376PubMedEurope PMCNat Commun 7:12547-12547 (2016)Mapped to21
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.Kupka S., De Miguel D., Draber P., Martino L., Surinova S., Rittinger K., Walczak H.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-66376PubMedEurope PMCCell Rep. 16:2271-2280 (2016)Cited in3Mapped to35
SPATA2 promotes CYLD activity and regulates TNF-induced NF-kappaB signaling and cell death.Schlicher L., Wissler M., Preiss F., Brauns-Schubert P., Jakob C., Dumit V., Borner C., Dengjel J., Maurer U.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-66376PubMedEurope PMCEMBO Rep. 17:1485-1497 (2016)Cited in4Mapped to16
SPATA2 links CYLD to the TNF-alpha receptor signaling complex and modulates the receptor signaling outcomes.Wagner S.A., Satpathy S., Beli P., Choudhary C.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-66376PubMedEurope PMCEMBO J. 35:1868-1884 (2016)Cited in2Mapped to22