Q15562 · TEAD2_HUMAN
- ProteinTranscriptional enhancer factor TEF-4
- GeneTEAD2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids447 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 38-114 | TEA | ||||
Sequence: GPDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRE |
GO annotations
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTranscriptional enhancer factor TEF-4
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ15562
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 565 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000205932 | 1-447 | UniProt | Transcriptional enhancer factor TEF-4 | |||
Sequence: MGEPRAGAALDDGSGWTGSEEGSEEGTGGSEGAGGDGGPDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKLGPTGPQASELFQFWSGGSGPPWNVPDVKPFSQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTPSPPAWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSGEEAGAGGSISSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD | |||||||
Modified residue (large scale data) | 71 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 260 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Interacts with YAP1 and WWTR1/TAZ.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q15562 | BCL2L15 Q5TBC7 | 4 | EBI-6427252, EBI-10247136 | |
BINARY | Q15562 | USF2 Q15853 | 3 | EBI-6427252, EBI-1055994 | |
BINARY | Q15562 | YAP1 P46937 | 9 | EBI-6427252, EBI-1044059 | |
BINARY | Q15562-2 | GNG13 Q9P2W3 | 3 | EBI-9370956, EBI-11427343 | |
BINARY | Q15562-2 | INPP5A Q14642 | 3 | EBI-9370956, EBI-8670520 | |
BINARY | Q15562-2 | RUNX1 Q01196-8 | 3 | EBI-9370956, EBI-12001422 | |
BINARY | Q15562-2 | SIX6OS1 Q8N1H7 | 3 | EBI-9370956, EBI-12182077 | |
BINARY | Q15562-2 | TRIM3 O75382 | 3 | EBI-9370956, EBI-2129889 | |
BINARY | Q15562-2 | VGLL1 Q99990 | 3 | EBI-9370956, EBI-11983165 | |
BINARY | Q15562-2 | VGLL3 A8MV65-2 | 3 | EBI-9370956, EBI-11957216 | |
BINARY | Q15562-2 | VGLL4 Q14135 | 3 | EBI-9370956, EBI-5278589 | |
BINARY | Q15562-2 | WWTR1 Q9GZV5 | 3 | EBI-9370956, EBI-747743 | |
BINARY | Q15562-2 | YAP1 P46937 | 3 | EBI-9370956, EBI-1044059 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-46 | Disordered | ||||
Sequence: MGEPRAGAALDDGSGWTGSEEGSEEGTGGSEGAGGDGGPDAEGVWS | ||||||
Region | 172-447 | Transcriptional activation | ||||
Sequence: WNVPDVKPFSQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTPSPPAWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSGEEAGAGGSISSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD | ||||||
Region | 183-218 | Disordered | ||||
Sequence: TPFTLSLTPPSTDLPGYEPPQALSPLPPPTPSPPAW | ||||||
Compositional bias | 195-217 | Pro residues | ||||
Sequence: DLPGYEPPQALSPLPPPTPSPPA |
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
Q15562-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length447
- Mass (Da)49,243
- Last updated2002-05-27 v2
- ChecksumA9077F55638A3AC7
Q15562-2
- Name2
- Differences from canonical
- 155-155: P → PQVV
Q15562-3
- Name3
Q15562-4
- Name4
- Differences from canonical
- 120-120: K → KALNV
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_045126 | 1-131 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_055673 | 120 | in isoform 4 | |||
Sequence: K → KALNV | ||||||
Sequence conflict | 144 | in Ref. 5; CAA64214 | ||||
Sequence: P → L | ||||||
Alternative sequence | VSP_045127 | 155 | in isoform 2 and isoform 3 | |||
Sequence: P → PQVV | ||||||
Compositional bias | 195-217 | Pro residues | ||||
Sequence: DLPGYEPPQALSPLPPPTPSPPA |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK093236 EMBL· GenBank· DDBJ | BAC04104.1 EMBL· GenBank· DDBJ | mRNA | ||
AK290736 EMBL· GenBank· DDBJ | BAF83425.1 EMBL· GenBank· DDBJ | mRNA | ||
AK300241 EMBL· GenBank· DDBJ | BAG62008.1 EMBL· GenBank· DDBJ | mRNA | ||
AC010524 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471177 EMBL· GenBank· DDBJ | EAW52469.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC051301 EMBL· GenBank· DDBJ | AAH51301.1 EMBL· GenBank· DDBJ | mRNA | ||
BC007556 EMBL· GenBank· DDBJ | AAH07556.1 EMBL· GenBank· DDBJ | mRNA | ||
BC018803 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
X94440 EMBL· GenBank· DDBJ | CAA64214.1 EMBL· GenBank· DDBJ | mRNA |