Q15390 · MTFR1_HUMAN

  • Protein
    Mitochondrial fission regulator 1
  • Gene
    MTFR1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrion
Cellular Componentplasma membrane
Biological Processaerobic respiration
Biological Processmitochondrial fission
Biological Processmitochondrion organization

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mitochondrial fission regulator 1
  • Alternative names
    • Chondrocyte protein with a poly-proline region

Gene names

    • Name
      MTFR1
    • Synonyms
      CHPPR, FAM54A2, KIAA0009

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q15390
  • Secondary accessions
    • E7EP84
    • Q6IB94
    • Q7Z669
    • Q86XH5
    • Q8IVD7

Proteomes

Organism-specific databases

Subcellular Location

Mitochondrion
Note: May be associated with the inner and the outer mitochondrial membrane.

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 359 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for transit peptide, chain, modified residue (large scale data), modified residue.

TypeIDPosition(s)SourceDescription
Transit peptide1-48UniProtMitochondrion
ChainPRO_000009662249-333UniProtMitochondrial fission regulator 1
Modified residue (large scale data)115PRIDEPhosphoserine
Modified residue119UniProtPhosphoserine
Modified residue (large scale data)119PRIDEPhosphoserine
Modified residue (large scale data)124PRIDEPhosphoserine
Modified residue (large scale data)290PRIDEPhosphoserine
Modified residue (large scale data)331PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q15390DIABLO Q9NR285EBI-724207, EBI-517508
BINARY Q15390SYT16 Q17RD73EBI-724207, EBI-10238936

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for coiled coil, region, compositional bias.

TypeIDPosition(s)Description
Coiled coil137-169
Region177-198Disordered
Region179-304Necessary and sufficient to promote mitochondrial fission
Compositional bias182-198Pro residues
Compositional bias288-303Basic and acidic residues
Region288-315Disordered

Sequence similarities

Belongs to the MTFR1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

Q15390-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    333
  • Mass (Da)
    37,000
  • Last updated
    2005-08-30 v2
  • Checksum
    ED8025FCF1B44827
MLGWIKRLIRMVFQQVGVSMQSVLWSRKPYGSSRSIVRKIGTNLSLIQCPRVQFQINSHATEWSPSHPGEDAVASFADVGWVAKEEGECSARLRTEVRSRPPLQDDLLFFEKAPSRQISLPDLSQEEPQLKTPALANEEALQKICALENELAALRAQIAKIVTQQEQQNLTAGDLDSTTFGTIPPHPPPPPPPLPPPALGLHQSTSAVDLIKERREKRANAGKTLVKNNPKKPEMPNMLEILKEMNSVKLRSVKRSEQDVKPKPVDATDPAALIAEALKKKFAYRYRSDSQDEVEKGIPKSESEATSERVLFGPHMLKPTGKMKALIENVSDS

Q15390-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H0YF01H0YF01_HUMANMTFR1185
H0YBZ4H0YBZ4_HUMANMTFR1291
H7C5V5H7C5V5_HUMANMTFR1144
E5RIB6E5RIB6_HUMANMTFR156

Sequence caution

The sequence BAA02798.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for alternative sequence, sequence conflict, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_04676523-55in isoform 2
Sequence conflict135in Ref. 1; AAH36116
Compositional bias182-198Pro residues
Compositional bias288-303Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC055822
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC036116
EMBL· GenBank· DDBJ
AAH36116.1
EMBL· GenBank· DDBJ
mRNA
BC043498
EMBL· GenBank· DDBJ
AAH43498.1
EMBL· GenBank· DDBJ
mRNA
BX537854
EMBL· GenBank· DDBJ
CAD97862.1
EMBL· GenBank· DDBJ
mRNA
D13634
EMBL· GenBank· DDBJ
BAA02798.1
EMBL· GenBank· DDBJ
mRNA Different initiation
CR456910
EMBL· GenBank· DDBJ
CAG33191.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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